Literature DB >> 31519494

The Alzheimer's Disease Exposome.

Caleb E Finch1, Alexander M Kulminski2.   

Abstract

INTRODUCTION: Environmental factors are poorly understood in the etiology of Alzheimer's disease (AD) and related dementias. The importance of environmental factors in gene environment interactions (GxE) is suggested by wide individual differences in cognitive loss, even for carriers of AD-risk genetic variants. RESULTS AND DISCUSSION: We propose the "AD exposome" to comprehensively assess the modifiable environmental factors relevant to genetic underpinnings of cognitive aging and AD. Analysis of endogenous and exogenous environmental factors requires multi-generational consideration of these interactions over age and time (GxExT). New computational approaches to the multi-level complexities may identify accessible interventions for individual brain aging. International collaborations on diverse populations are needed to identify the most relevant exposures over the life course for GxE interactions.
Copyright © 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alzheimer's disease; Environment; Exposome; GxE; Infections; Toxins

Year:  2019        PMID： 31519494      PMCID： PMC6788638          DOI： 10.1016/j.jalz.2019.06.3914

Source DB:  PubMed          Journal:  Alzheimers Dement        ISSN： 1552-5260            Impact factor:   21.566


  154 in total

Review 1.  Nature, nurture and mental disorder: old concepts in the new millennium.

Authors:  B Cooper
Journal:  Br J Psychiatry Suppl       Date:  2001-04

2.  Future prospects and challenges for Alzheimer's disease drug development in the era of the NIA-AA Research Framework.

Authors:  Ara S Khachaturian; Kathleen M Hayden; Michelle M Mielke; Yi Tang; Michael W Lutz; Deborah R Gustafson; Walter A Kukull; Richard Mohs; Zaven S Khachaturian
Journal:  Alzheimers Dement       Date:  2018-04       Impact factor: 21.566

3.  Tobacco Smoking and Dementia in a Kentucky Cohort: A Competing Risk Analysis.

Authors:  Erin L Abner; Peter T Nelson; Gregory A Jicha; Gregory E Cooper; David W Fardo; Frederick A Schmitt; Richard J Kryscio
Journal:  J Alzheimers Dis       Date:  2019       Impact factor: 4.472

Review 4.  Sex differences in Alzheimer disease - the gateway to precision medicine.

Authors:  Maria Teresa Ferretti; Maria Florencia Iulita; Enrica Cavedo; Patrizia Andrea Chiesa; Annemarie Schumacher Dimech; Antonella Santuccione Chadha; Francesca Baracchi; Hélène Girouard; Sabina Misoch; Ezio Giacobini; Herman Depypere; Harald Hampel
Journal:  Nat Rev Neurol       Date:  2018-08       Impact factor: 42.937

Review 5.  Cognitive sequelae of traumatic brain injury.

Authors:  Amanda R Rabinowitz; Harvey S Levin
Journal:  Psychiatr Clin North Am       Date:  2014-01-14

6.  Blood-brain barrier breakdown in the aging human hippocampus.

Authors:  Axel Montagne; Samuel R Barnes; Melanie D Sweeney; Matthew R Halliday; Abhay P Sagare; Zhen Zhao; Arthur W Toga; Russell E Jacobs; Collin Y Liu; Lilyana Amezcua; Michael G Harrington; Helena C Chui; Meng Law; Berislav V Zlokovic
Journal:  Neuron       Date:  2015-01-21       Impact factor: 17.173

7.  The human early-life exposome (HELIX): project rationale and design.

Authors:  Martine Vrijheid; Rémy Slama; Oliver Robinson; Leda Chatzi; Muireann Coen; Peter van den Hazel; Cathrine Thomsen; John Wright; Toby J Athersuch; Narcis Avellana; Xavier Basagaña; Celine Brochot; Luca Bucchini; Mariona Bustamante; Angel Carracedo; Maribel Casas; Xavier Estivill; Lesley Fairley; Diana van Gent; Juan R Gonzalez; Berit Granum; Regina Gražulevičienė; Kristine B Gutzkow; Jordi Julvez; Hector C Keun; Manolis Kogevinas; Rosemary R C McEachan; Helle Margrete Meltzer; Eduard Sabidó; Per E Schwarze; Valérie Siroux; Jordi Sunyer; Elizabeth J Want; Florence Zeman; Mark J Nieuwenhuijsen
Journal:  Environ Health Perspect       Date:  2014-03-07       Impact factor: 9.031

Review 8.  NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease.

Authors:  Clifford R Jack; David A Bennett; Kaj Blennow; Maria C Carrillo; Billy Dunn; Samantha Budd Haeberlein; David M Holtzman; William Jagust; Frank Jessen; Jason Karlawish; Enchi Liu; Jose Luis Molinuevo; Thomas Montine; Creighton Phelps; Katherine P Rankin; Christopher C Rowe; Philip Scheltens; Eric Siemers; Heather M Snyder; Reisa Sperling
Journal:  Alzheimers Dement       Date:  2018-04       Impact factor: 21.566

9.  Comparison of Methods for Algorithmic Classification of Dementia Status in the Health and Retirement Study.

Authors:  Kan Z Gianattasio; Qiong Wu; M Maria Glymour; Melinda C Power
Journal:  Epidemiology       Date:  2019-03       Impact factor: 4.822

Review 10.  Geographical variation in dementia: systematic review with meta-analysis.

Authors:  Tom C Russ; G David Batty; Gena F Hearnshaw; Candida Fenton; John M Starr
Journal:  Int J Epidemiol       Date:  2012-07-13       Impact factor: 7.196
View more
  19 in total

1.  Fast Algorithms for Conducting Large-Scale GWAS of Age-at-Onset Traits Using Cox Mixed-Effects Models.

Authors:  Liang He; Alexander M Kulminski
Journal:  Genetics       Date:  2020-03-04       Impact factor: 4.562

2.  Definitive roles of TOMM40-APOE-APOC1 variants in the Alzheimer's risk.

Authors:  Alexander M Kulminski; Ian Philipp; Leonardo Shu; Irina Culminskaya
Journal:  Neurobiol Aging       Date:  2021-09-15       Impact factor: 4.673

3.  Genome-wide analysis identified abundant genetic modulators of contributions of the apolipoprotein E alleles to Alzheimer's disease risk.

Authors:  Alireza Nazarian; Yury Loika; Liang He; Irina Culminskaya; Alexander M Kulminski
Journal:  Alzheimers Dement       Date:  2022-01-03       Impact factor: 16.655

4.  Using the exposome to understand environmental contributors to psychiatric disorders.

Authors:  James P Burkett; Gary W Miller
Journal:  Neuropsychopharmacology       Date:  2021-01       Impact factor: 7.853

5.  Gene-Environment Interactions and Stochastic Variations in the Gero-Exposome.

Authors:  Caleb E Finch; Amin Haghani
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2021-09-13       Impact factor: 6.053

6.  Association Between Ambient Air Pollution and Amyloid Positron Emission Tomography Positivity in Older Adults With Cognitive Impairment.

Authors:  Leonardo Iaccarino; Renaud La Joie; Orit H Lesman-Segev; Eunice Lee; Lucy Hanna; Isabel E Allen; Bruce E Hillner; Barry A Siegel; Rachel A Whitmer; Maria C Carrillo; Constantine Gatsonis; Gil D Rabinovici
Journal:  JAMA Neurol       Date:  2021-02-01       Impact factor: 18.302

7.  The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans.

Authors:  Amin Haghani; Max Thorwald; Todd E Morgan; Caleb E Finch
Journal:  Alzheimers Dement       Date:  2020-11-20       Impact factor: 21.566

8.  Protective association of the ε2/ε3 heterozygote with Alzheimer's disease is strengthened by TOMM40-APOE variants in men.

Authors:  Alexander M Kulminski; Ian Philipp; Yury Loika; Liang He; Irina Culminskaya
Journal:  Alzheimers Dement       Date:  2021-07-26       Impact factor: 21.566

Review 9.  Human Health Exposure Analysis Resource (HHEAR): A model for incorporating the exposome into health studies.

Authors:  Susan Marie Viet; Jill C Falman; Lori S Merrill; Elaine M Faustman; David A Savitz; Nancy Mervish; Dana B Barr; Lisa A Peterson; Robert Wright; David Balshaw; Barbara O'Brien
Journal:  Int J Hyg Environ Health       Date:  2021-05-23       Impact factor: 7.401

10.  THE EXPOSOME IN HUMAN EVOLUTION: FROM DUST TO DIESEL.

Authors:  Benjamin C Trumble; Caleb E Finch
Journal:  Q Rev Biol       Date:  2019-12       Impact factor: 6.750
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.