Matthew J O'Brien1,2,3, David B Sacks4. 1. Division of General Internal Medicine and Geriatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois. 2. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois. 3. Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois. 4. Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland.