| Literature DB >> 31508793 |
Cintia Kazuko Tokuhara1, Mariana Rodrigues Santesso1, Gabriela Silva Neubern de Oliveira1, Talita Mendes da Silva Ventura1, Julio Toshimi Doyama2, Willian Fernando Zambuzzi2, Rodrigo Cardoso de Oliveira1.
Abstract
Bone development and healing processes involve a complex cascade of biological events requiring well-orchestrated synergism with bone cells, growth factors, and other trophic signaling molecules and cellular structures. Beyond health processes, MMPs play several key roles in the installation of heart and blood vessel related diseases and cancer, ranging from accelerating metastatic cells to ectopic vascular mineralization by smooth muscle cells in complementary manner. The tissue inhibitors of MMPs (TIMPs) have an important role in controlling proteolysis. Paired with the post-transcriptional efficiency of specific miRNAs, they modulate MMP performance. If druggable, these molecules are suggested to be a platform for development of "smart" medications and further clinical trials. Thus, considering the pleiotropic effect of MMPs on mammals, the purpose of this review is to update the role of those multifaceted proteases in mineralized tissues in health, such as bone, and pathophysiological disorders, such as ectopic vascular calcification and cancer.Entities:
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Year: 2019 PMID： 31508793 DOI： 10.1590/1678-7757-2018-0596
Source DB: PubMed Journal: J Appl Oral Sci ISSN： 1678-7757 Impact factor: 2.698