Lennard L van Wanrooij1, Edo Richard2, Susan Jongstra3, Eric P Moll van Charante4, Willem A van Gool3. 1. Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam, The Netherlands l.l.vanwanrooij@amc.uva.nl. 2. Donders Institute of Brain, Cognition, and Behavior, Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands. 3. Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam, The Netherlands. 4. Amsterdam UMC, University of Amsterdam, Department of Family Medicine, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Abstract
PURPOSE: Family physicians need simple yet comprehensive algorithms to discriminate between community-dwelling older persons who are at increased risk of dementia and those who are not. We aimed to investigate associations between incident dementia and responses to a single question regarding subjective memory complaints (SMC) combined with scores on 2 simple memory tests that are easy to use in the primary care setting. METHODS: Analyses were based on data from 3,454 community-dwelling older persons who participated in the 6- to 8-year Prevention of Dementia by Intensive Vascular Care (preDIVA) trial, yielding 21,341 person-years of observation. Participants were considered a single cohort. We used Cox models to assess separate and combined associations of SMC, an imperfect score on the Mini-Mental State Examination delayed recall item (MMSE-5), and an imperfect score on the Visual Association Test (VAT) with future dementia. RESULTS: Subjective memory complaints alone were associated with future dementia (hazard ratio [HR] = 3.01; 95% CI, 2.31-3.94; P <.001), as were the MMSE-5 (HR = 2.14; 95% CI, 1.59-2.87; P <.001) and VAT (HR = 3.19; 95% CI, 2.46-4.13; P <.001) scores. After a median follow-up of 6.7 years, the occurrence of dementia ranged from 4% to 30% among persons with SMC, depending on the MMSE-5 and VAT scores. These test scores did not substantially alter the association with future dementia for persons without SMC. CONCLUSIONS: In persons with SMC, the strength of the association between future dementia and an imperfect MMSE-5 score depends substantially on the VAT score.
PURPOSE: Family physicians need simple yet comprehensive algorithms to discriminate between community-dwelling older persons who are at increased risk of dementia and those who are not. We aimed to investigate associations between incident dementia and responses to a single question regarding subjective memory complaints (SMC) combined with scores on 2 simple memory tests that are easy to use in the primary care setting. METHODS: Analyses were based on data from 3,454 community-dwelling older persons who participated in the 6- to 8-year Prevention of Dementia by Intensive Vascular Care (preDIVA) trial, yielding 21,341 person-years of observation. Participants were considered a single cohort. We used Cox models to assess separate and combined associations of SMC, an imperfect score on the Mini-Mental State Examination delayed recall item (MMSE-5), and an imperfect score on the Visual Association Test (VAT) with future dementia. RESULTS: Subjective memory complaints alone were associated with future dementia (hazard ratio [HR] = 3.01; 95% CI, 2.31-3.94; P <.001), as were the MMSE-5 (HR = 2.14; 95% CI, 1.59-2.87; P <.001) and VAT (HR = 3.19; 95% CI, 2.46-4.13; P <.001) scores. After a median follow-up of 6.7 years, the occurrence of dementia ranged from 4% to 30% among persons with SMC, depending on the MMSE-5 and VAT scores. These test scores did not substantially alter the association with future dementia for persons without SMC. CONCLUSIONS: In persons with SMC, the strength of the association between future dementia and an imperfect MMSE-5 score depends substantially on the VAT score.
Authors: Eric P Moll van Charante; Edo Richard; Lisa S Eurelings; Jan-Willem van Dalen; Suzanne A Ligthart; Emma F van Bussel; Marieke P Hoevenaar-Blom; Marinus Vermeulen; Willem A van Gool Journal: Lancet Date: 2016-07-26 Impact factor: 79.321
Authors: Susan Jongstra; Willem A van Gool; Eric P Moll van Charante; Jan-Willem van Dalen; Lisa S M Eurelings; Edo Richard; Suzanne A Ligthart Journal: Ann Fam Med Date: 2018-05 Impact factor: 5.166
Authors: Emma F van Bussel; Edo Richard; Derk L Arts; Astrid C J Nooyens; Preciosa M Coloma; Margot W M de Waal; Marjan van den Akker; Marion C J Biermans; Markus M J Nielen; Kees van Boven; Hugo Smeets; Fiona E Matthews; Carol Brayne; Wim B Busschers; Willem A van Gool; Eric P Moll van Charante Journal: PLoS Med Date: 2017-03-07 Impact factor: 11.069
Authors: Leah Zuroff; Laura Em Wisse; Trevor Glenn; Sharon X Xie; Ilya M Nasrallah; Mohamad Habes; Jacob Dubroff; Robin de Flores; Long Xie; Paul Yushkevich; Jimit Doshi; Christos Davatsikos; Leslie M Shaw; Thomas F Tropea; Alice S Chen-Plotkin; David A Wolk; Sandhitsu Das; Dawn Mechanic-Hamilton Journal: J Alzheimers Dis Rep Date: 2022-07-22