Sandhitsu R Das1, Long Xie2, Laura E M Wisse3, Nicolas Vergnet4, Ranjit Ittyerah2, Salena Cui5, Paul A Yushkevich6, David A Wolk7. 1. Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA; Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, PA, USA; Penn Memory Center, University of Pennsylvania, Philadelphia, PA, USA; Penn Alzheimer's Disease Core Center, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: sudas@seas.upenn.edu. 2. Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, PA, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA. 3. Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, PA, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA; Penn Memory Center, University of Pennsylvania, Philadelphia, PA, USA. 4. Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, PA, USA. 5. Jefferson University, Philadelphia, PA, USA. 6. Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, PA, USA; Penn Alzheimer's Disease Core Center, University of Pennsylvania, Philadelphia, PA, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA. 7. Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA; Penn Memory Center, University of Pennsylvania, Philadelphia, PA, USA; Penn Alzheimer's Disease Core Center, University of Pennsylvania, Philadelphia, PA, USA.
Abstract
INTRODUCTION: It is unclear the degree to which tau pathology in the medial temporal lobe (MTL) measured by 18F-flortaucipir positron emission tomography relates to MTL subregional atrophy and whether this relationship differs between amyloid-β-positive and amyloid-β-negative individuals. METHODS: We analyzed correlation of MTL 18F-flortaucipir uptake with MTL subregional atrophy measured with high-resolution magnetic resonance imaging in a region of interest and regional thickness analysis and determined the relationship between memory performance and positron emission tomography and magnetic resonance imaging measures. RESULTS: Both groups showed strong correlations between 18F-flortaucipir uptake and atrophy, with similar spatial patterns. Effects in the rhinal cortex recapitulated Braak staging. Correlations of memory recall with atrophy and tracer uptake were observed. DISCUSSION: Correlation patterns between tau burden and atrophy in the amyloid-β-negative group mimicking early Braak stages suggests that 18F-flortaucipir is sensitive to tau pathology in primary age-related tauopathy. Correlations of imaging measures with memory performance indicate that this pathology is associated with poorer cognition.
INTRODUCTION: It is unclear the degree to which tau pathology in the medial temporal lobe (MTL) measured by 18F-flortaucipir positron emission tomography relates to MTL subregional atrophy and whether this relationship differs between amyloid-β-positive and amyloid-β-negative individuals. METHODS: We analyzed correlation of MTL 18F-flortaucipir uptake with MTL subregional atrophy measured with high-resolution magnetic resonance imaging in a region of interest and regional thickness analysis and determined the relationship between memory performance and positron emission tomography and magnetic resonance imaging measures. RESULTS: Both groups showed strong correlations between 18F-flortaucipir uptake and atrophy, with similar spatial patterns. Effects in the rhinal cortex recapitulated Braak staging. Correlations of memory recall with atrophy and tracer uptake were observed. DISCUSSION: Correlation patterns between tau burden and atrophy in the amyloid-β-negative group mimicking early Braak stages suggests that 18F-flortaucipir is sensitive to tau pathology in primary age-related tauopathy. Correlations of imaging measures with memory performance indicate that this pathology is associated with poorer cognition.
Authors: Paul A Yushkevich; John B Pluta; Hongzhi Wang; Long Xie; Song-Lin Ding; Eske C Gertje; Lauren Mancuso; Daria Kliot; Sandhitsu R Das; David A Wolk Journal: Hum Brain Mapp Date: 2014-09-02 Impact factor: 5.038
Authors: Sandhitsu R Das; Long Xie; Laura E M Wisse; Ranjit Ittyerah; Nicholas J Tustison; Bradford C Dickerson; Paul A Yushkevich; David A Wolk Journal: Neurobiol Aging Date: 2018-02-09 Impact factor: 4.673
Authors: Reisa A Sperling; Elizabeth C Mormino; Aaron P Schultz; Rebecca A Betensky; Kathryn V Papp; Rebecca E Amariglio; Bernard J Hanseeuw; Rachel Buckley; Jasmeer Chhatwal; Trey Hedden; Gad A Marshall; Yakeel T Quiroz; Nancy J Donovan; Jonathan Jackson; Jennifer R Gatchel; Jennifer S Rabin; Heidi Jacobs; Hyun-Sik Yang; Michael Properzi; Dylan R Kirn; Dorene M Rentz; Keith A Johnson Journal: Ann Neurol Date: 2019-01-21 Impact factor: 10.422
Authors: Michael Schöll; Samuel N Lockhart; Daniel R Schonhaut; James P O'Neil; Mustafa Janabi; Rik Ossenkoppele; Suzanne L Baker; Jacob W Vogel; Jamie Faria; Henry D Schwimmer; Gil D Rabinovici; William J Jagust Journal: Neuron Date: 2016-03-02 Impact factor: 17.173
Authors: Christopher M Lee; Heidi I L Jacobs; Marta Marquié; John A Becker; Nicolas V Andrea; David S Jin; Aaron P Schultz; Matthew P Frosch; Teresa Gómez-Isla; Reisa A Sperling; Keith A Johnson Journal: J Alzheimers Dis Date: 2018 Impact factor: 4.472
Authors: Alexandre Bejanin; Daniel R Schonhaut; Renaud La Joie; Joel H Kramer; Suzanne L Baker; Natasha Sosa; Nagehan Ayakta; Averill Cantwell; Mustafa Janabi; Mariella Lauriola; James P O'Neil; Maria L Gorno-Tempini; Zachary A Miller; Howard J Rosen; Bruce L Miller; William J Jagust; Gil D Rabinovici Journal: Brain Date: 2017-12-01 Impact factor: 13.501
Authors: Marta Marquié; Marc D Normandin; Charles R Vanderburg; Isabel M Costantino; Elizabeth A Bien; Lisa G Rycyna; William E Klunk; Chester A Mathis; Milos D Ikonomovic; Manik L Debnath; Neil Vasdev; Bradford C Dickerson; Stephen N Gomperts; John H Growdon; Keith A Johnson; Matthew P Frosch; Bradley T Hyman; Teresa Gómez-Isla Journal: Ann Neurol Date: 2015-09-25 Impact factor: 10.422
Authors: John F Crary; John Q Trojanowski; Julie A Schneider; Jose F Abisambra; Erin L Abner; Irina Alafuzoff; Steven E Arnold; Johannes Attems; Thomas G Beach; Eileen H Bigio; Nigel J Cairns; Dennis W Dickson; Marla Gearing; Lea T Grinberg; Patrick R Hof; Bradley T Hyman; Kurt Jellinger; Gregory A Jicha; Gabor G Kovacs; David S Knopman; Julia Kofler; Walter A Kukull; Ian R Mackenzie; Eliezer Masliah; Ann McKee; Thomas J Montine; Melissa E Murray; Janna H Neltner; Ismael Santa-Maria; William W Seeley; Alberto Serrano-Pozo; Michael L Shelanski; Thor Stein; Masaki Takao; Dietmar R Thal; Jonathan B Toledo; Juan C Troncoso; Jean Paul Vonsattel; Charles L White; Thomas Wisniewski; Randall L Woltjer; Masahito Yamada; Peter T Nelson Journal: Acta Neuropathol Date: 2014-10-28 Impact factor: 17.088
Authors: Laura Em Wisse; Long Xie; Sandhitsu R Das; Robin de Flores; Oskar Hansson; Mohamad Habes; Jimit Doshi; Christos Davatzikos; Paul A Yushkevich; David A Wolk Journal: Neurobiol Aging Date: 2021-09-24 Impact factor: 5.133
Authors: Dallas P Veitch; Michael W Weiner; Paul S Aisen; Laurel A Beckett; Charles DeCarli; Robert C Green; Danielle Harvey; Clifford R Jack; William Jagust; Susan M Landau; John C Morris; Ozioma Okonkwo; Richard J Perrin; Ronald C Petersen; Monica Rivera-Mindt; Andrew J Saykin; Leslie M Shaw; Arthur W Toga; Duygu Tosun; John Q Trojanowski Journal: Alzheimers Dement Date: 2021-09-28 Impact factor: 16.655
Authors: Sadhana Ravikumar; Laura E M Wisse; Sydney Lim; Ranjit Ittyerah; Long Xie; Madigan L Bedard; Sandhitsu R Das; Edward B Lee; M Dylan Tisdall; Karthik Prabhakaran; Jacqueline Lane; John A Detre; Gabor Mizsei; John Q Trojanowski; John L Robinson; Theresa Schuck; Murray Grossman; Emilio Artacho-Pérula; Maria Mercedes Iñiguez de Onzoño Martin; María Del Mar Arroyo Jiménez; Monica Muñoz; Francisco Javier Molina Romero; Maria Del Pilar Marcos Rabal; Sandra Cebada Sánchez; José Carlos Delgado González; Carlos de la Rosa Prieto; Marta Córcoles Parada; David J Irwin; David A Wolk; Ricardo Insausti; Paul A Yushkevich Journal: Acta Neuropathol Commun Date: 2021-10-24 Impact factor: 7.801
Authors: L E M Wisse; S Ravikumar; R Ittyerah; S Lim; J Lane; M L Bedard; L Xie; S R Das; T Schuck; M Grossman; E B Lee; M D Tisdall; K Prabhakaran; J A Detre; G Mizsei; J Q Trojanowski; E Artacho-Pérula; M M de Iñiguez de Onzono Martin; M M Arroyo-Jiménez; M Muñoz Lopez; F J Molina Romero; M P Marcos Rabal; S Cebada Sánchez; J C Delgado González; C de la Rosa Prieto; M Córcoles Parada; D A Wolk; D J Irwin; R Insausti; P A Yushkevich Journal: Acta Neuropathol Commun Date: 2021-07-21 Impact factor: 7.801
Authors: Long Xie; Laura E M Wisse; Sandhitsu R Das; Nicolas Vergnet; Mengjin Dong; Ranjit Ittyerah; Robin de Flores; Paul A Yushkevich; David A Wolk Journal: Hum Brain Mapp Date: 2020-08-26 Impact factor: 5.038
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