Shaheen Hasmat1,2, Ardalan Ebrahimi1,3, Kan Gao1, Tsu-Hui Hubert Low1,2, Carsten Palme, Ruta Gupta1,2,4, Jonathan Clark1,2. 1. Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, New South Wales, Australia. 2. Central Clinical School, University of Sydney, Sydney, New South Wales, Australia. 3. Medical School College of Health and Medicine, Australian National University, Canberra, Australia. 4. Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.
Abstract
OBJECTIVES: Prognostic significance of perineural invasion (PNI) in oral squamous cell carcinoma (OSCC) characterized as unifocal and multifocal was compared to depth of invasion (DOI) and extranodal extension (ENE). MATERIALS AND METHODS: Univariable and multivariable analyses of 861 consecutive patients with OSCC undergoing treatment between 1995 and 2018 were performed, with local failure (LF) and disease-specific mortality (DSS) as the primary endpoints. RESULTS: After adjusting for other adverse histopathological factors and adjuvant therapy, multifocal PNI was associated with a greater risk of LF (P = .01) and DSS (P = 0.02) compared to DOI. The effect of multifocal PNI was comparable to the effect of nodal metastases without ENE (P = 0.02). LF and DSS were not improved by the administration of adjuvant radiotherapy within unifocal or multifocal PNI groups. CONCLUSION: Multifocal PNI is associated with a greater risk of death in OSCC than DOI. Its effect is comparable to that of nodal metastases (without ENE).
OBJECTIVES: Prognostic significance of perineural invasion (PNI) in oral squamous cell carcinoma (OSCC) characterized as unifocal and multifocal was compared to depth of invasion (DOI) and extranodal extension (ENE). MATERIALS AND METHODS: Univariable and multivariable analyses of 861 consecutive patients with OSCC undergoing treatment between 1995 and 2018 were performed, with local failure (LF) and disease-specific mortality (DSS) as the primary endpoints. RESULTS: After adjusting for other adverse histopathological factors and adjuvant therapy, multifocal PNI was associated with a greater risk of LF (P = .01) and DSS (P = 0.02) compared to DOI. The effect of multifocal PNI was comparable to the effect of nodal metastases without ENE (P = 0.02). LF and DSS were not improved by the administration of adjuvant radiotherapy within unifocal or multifocal PNI groups. CONCLUSION: Multifocal PNI is associated with a greater risk of death in OSCC than DOI. Its effect is comparable to that of nodal metastases (without ENE).
Authors: Flora Yan; Yi-Shing Lisa Cheng; Nora Katabi; Shaun A Nguyen; Huey-Shys Chen; Patrick Morgan; Kathy Zhang; Angela C Chi Journal: Head Neck Pathol Date: 2021-03-31
Authors: Ligia B Schmitd; Cindy Perez-Pacheco; Emily L Bellile; Weisheng Wu; Keith Casper; Michelle Mierzwa; Laura S Rozek; Gregory T Wolf; Jeremy M G Taylor; Nisha J D'Silva Journal: Clin Cancer Res Date: 2022-08-15 Impact factor: 13.801