Pınar Kösekahya1, Cemile Üçgül Atılgan2, Kadir Gökhan Atılgan2, Mustafa Koç1, Kemal Tekin3, Mehtap Çağlayan4, Yasin Şakir Göker1. 1. Ulucanlar Eye Training and Research Hospital, Ophthalmology Clinic, Ankara, Turkey 2. Dışkapı Training and Research Hospital, Nephrology Clinic, Ankara, Turkey 3. Van Erciş State Hospital, Ophthalmology Clinic, Van, Turkey 4. Gazi Yaşargil Training and Research Hospital, Ophthalmology Clinic, Diyarbakır, Turkey
Abstract
Objectives: To investigate corneal endothelial cell density (ECD), morphology, and central corneal thickness (CCT) in patients with gout compared with healthy subjects. Materials and Methods: Fifty eyes of 50 gout patients and 50 eyes of 50 healthy subjects without gout or any other systemic disease were included in this study. After detailed ophthalmologic examination, specular microscopy (Tomey EM-4000; Tomey Corp) measurement was performed for all participants. ECD, average cell area (ACA), coefficient of variation (CV), hexagonality ratio, and CCT values were recorded. Results: Mean ECD and hexagonality ratio were lower (p=0.004 and p=0.002) and CV, ACA, and CCT values were higher (p=0.001, p=0.007, and p=0.001) in patients with gout when compared to healthy subjects. There were significant correlations between gout disease duration and CD and hexagonality ratio (p=0.019 and p=0.043) and also between uric acid value and hexagonality ratio and CCT (p=0.044 and p=0.003). Conclusion: Altered corneal endothelial function was found in patients with gout when compared to healthy subjects and the alteration increased as gout duration and uric acid value increased.
Objectives: To investigate corneal endothelial cell density (ECD), morphology, and central corneal thickness (CCT) in patients with gout compared with healthy subjects. Materials and Methods: Fifty eyes of 50 goutpatients and 50 eyes of 50 healthy subjects without gout or any other systemic disease were included in this study. After detailed ophthalmologic examination, specular microscopy (Tomey EM-4000; Tomey Corp) measurement was performed for all participants. ECD, average cell area (ACA), coefficient of variation (CV), hexagonality ratio, and CCT values were recorded. Results: Mean ECD and hexagonality ratio were lower (p=0.004 and p=0.002) and CV, ACA, and CCT values were higher (p=0.001, p=0.007, and p=0.001) in patients with gout when compared to healthy subjects. There were significant correlations between gout disease duration and CD and hexagonality ratio (p=0.019 and p=0.043) and also between uric acid value and hexagonality ratio and CCT (p=0.044 and p=0.003). Conclusion: Altered corneal endothelial function was found in patients with gout when compared to healthy subjects and the alteration increased as gout duration and uric acid value increased.
Authors: Veronique Vitart; Igor Rudan; Caroline Hayward; Nicola K Gray; James Floyd; Colin N A Palmer; Sara A Knott; Ivana Kolcic; Ozren Polasek; Juergen Graessler; James F Wilson; Anthony Marinaki; Philip L Riches; Xinhua Shu; Branka Janicijevic; Nina Smolej-Narancic; Barbara Gorgoni; Joanne Morgan; Susan Campbell; Zrinka Biloglav; Lovorka Barac-Lauc; Marijana Pericic; Irena Martinovic Klaric; Lina Zgaga; Tatjana Skaric-Juric; Sarah H Wild; William A Richardson; Peter Hohenstein; Charley H Kimber; Albert Tenesa; Louise A Donnelly; Lynette D Fairbanks; Martin Aringer; Paul M McKeigue; Stuart H Ralston; Andrew D Morris; Pavao Rudan; Nicholas D Hastie; Harry Campbell; Alan F Wright Journal: Nat Genet Date: 2008-03-09 Impact factor: 38.330
Authors: Ruchi Shah; Cynthia Amador; Kati Tormanen; Sean Ghiam; Mehrnoosh Saghizadeh; Vaithi Arumugaswami; Ashok Kumar; Andrei A Kramerov; Alexander V Ljubimov Journal: Exp Eye Res Date: 2021-01-21 Impact factor: 3.467