| Literature DB >> 33485845 |
Ruchi Shah1, Cynthia Amador2, Kati Tormanen3, Sean Ghiam4, Mehrnoosh Saghizadeh5, Vaithi Arumugaswami6, Ashok Kumar7, Andrei A Kramerov2, Alexander V Ljubimov8.
Abstract
There is a number of systemic diseases affecting the cornea. These include endocrine disorders (diabetes, Graves' disease, Addison's disease, hyperparathyroidism), infections with viruses (SARS-CoV-2, herpes simplex, varicella zoster, HTLV-1, Epstein-Barr virus) and bacteria (tuberculosis, syphilis and Pseudomonas aeruginosa), autoimmune and inflammatory diseases (rheumatoid arthritis, Sjögren's syndrome, lupus erythematosus, gout, atopic and vernal keratoconjunctivitis, multiple sclerosis, granulomatosis with polyangiitis, sarcoidosis, Cogan's syndrome, immunobullous diseases), corneal deposit disorders (Wilson's disease, cystinosis, Fabry disease, Meretoja's syndrome, mucopolysaccharidosis, hyperlipoproteinemia), and genetic disorders (aniridia, Ehlers-Danlos syndromes, Marfan syndrome). Corneal manifestations often provide an insight to underlying systemic diseases and can act as the first indicator of an undiagnosed systemic condition. Routine eye exams can bring attention to potentially life-threatening illnesses. In this review, we provide a fairly detailed overview of the pathologic changes in the cornea described in various systemic diseases and also discuss underlying molecular mechanisms, as well as current and emerging treatments.Entities:
Keywords: Addison's disease; Aniridia; Autoimmune disease; Corneal deposit disorder; Diabetic cornea; Ehlers-Danlos syndrome; Genetic corneal disease; Graves' disease; Herpes; Immunobullous disease; Inflammation; Keratoconjunctivitis; Marfan syndrome; Pseudomonas aeruginosa; SARS-CoV-2; Sjögren's syndrome; Syphilis; Tuberculosis; Zoster
Mesh：
Year: 2021 PMID： 33485845 PMCID： PMC7946758 DOI： 10.1016/j.exer.2021.108455
Source DB: PubMed Journal: Exp Eye Res ISSN： 0014-4835 Impact factor: 3.467