Literature DB >> 31483071

CD56- CD16+ NK cells from HIV-infected individuals negatively regulate IFN-γ production by autologous CD8+ T cells.

Meichen Ma1,2,3,4, Xiaowan Yin1,2,3,4, Xue Zhao1,2,3,4, Chenxi Guo1,2,3,4, Xiaoyu Zhu1,2,3,4, Tingting Liu1,2,3,4, Mei Yang1,2,3,4, Zining Zhang1,2,3,4, Yajing Fu1,2,3,4, Jing Liu1,2,3,4, Junjie Xu1,2,3,4, Haibo Ding1,2,3,4, Xiaoxu Han1,2,3,4, Zhenxing Chu1,2,3,4, Hong Shang1,2,3,4, Yongjun Jiang1,2,3,4.   

Abstract

The percentage of human CD56- CD16+ NK cells increases during chronic infection with human HIV; however, the biologic role of CD56- CD16+ NK cells in HIV infection is unclear. Our results demonstrate that the percentage of CD56- CD16+ NK cells producing IL-10 and TGF-β was higher than CD56dim CD16+ NK cells. CD56- CD16+ NK cells could inhibit IFN-γ production by autologous CD8+ T cells, and this inhibition could be partially reversed by anti-IL-10, anti-TGF-β, or anti-PD-L1 mAbs. CD56- CD16+ NK cells are potential targets for the development of novel immune therapies against HIV infection. ©2019 Society for Leukocyte Biology.

Entities:  

Keywords:  IL-10; NK; PD-L1; TGF-β

Mesh：

Substances：

Year:  2019        PMID： 31483071     DOI： 10.1002/JLB.3A0819-171RR

Source DB:  PubMed          Journal:  J Leukoc Biol        ISSN： 0741-5400            Impact factor:   4.962


  6 in total

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2.  CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation.

Authors:  Shi Qian; Chunbin Xiong; Meiting Wang; Zining Zhang; Yajing Fu; Qinghai Hu; Haibo Ding; Xiaoxu Han; Hong Shang; Yongjun Jiang
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Journal:  Front Immunol       Date:  2020-10-14       Impact factor: 7.561

4.  Immune Dysfunctions of CD56neg NK Cells Are Associated With HIV-1 Disease Progression.

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Review 5.  Negative Regulation and Protective Function of Natural Killer Cells in HIV Infection: Two Sides of a Coin.

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Journal:  Front Immunol       Date:  2022-03-07       Impact factor: 7.561

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  6 in total

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