Literature DB >> 31481438

Possible Binding of Piperine in Mycobacterium tuberculosis RNA Polymerase and Rifampin Synergism.

Letícia Sayuri Murase1, João Vítor Perez de Souza2, Katiany Rizzieri Caleffi Ferracioli2, Rosilene Fressatti Cardoso2, Jean Eduardo Meneguello2, Flavio Augusto Vicente Seixas3, Laíse Adriane Hegeto2, Regiane Bertin de Lima Scodro2, Vera Lucia Dias Siqueira2.   

Abstract

The activity of rifampin (RIF) and piperine was evaluated at the relative transcript levels of 12 efflux pumps (EPs), and an additional mechanism was proposed to be behind the synergic interactions of piperine plus RIF in Mycobacterium tuberculosis AutoDock v4.2.3 and Molegro v6 programs were used to evaluate PIP binding in M. tuberculosis RNA polymerase (RNAP). A hypothesis has been raised that piperine interferes in M. tuberculosis growth through RNAP inhibition, differently from what was previously endorsed for EP inhibition only.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  RNA polymerase; docking; efflux pumps; piperine; rifampin; tuberculosis

Mesh：

Substances：

Year:  2019        PMID： 31481438      PMCID： PMC6811433          DOI： 10.1128/AAC.02520-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  30 in total

Review 1.  A balancing act: efflux/influx in mycobacterial drug resistance.

Authors:  G E Louw; R M Warren; N C Gey van Pittius; C R E McEvoy; P D Van Helden; T C Victor
Journal:  Antimicrob Agents Chemother       Date:  2009-05-18       Impact factor: 5.191

2.  Morphological changes and differentially expressed efflux pump genes in Mycobacterium tuberculosis exposed to a rifampicin and verapamil combination.

Authors:  Katiany R Caleffi-Ferracioli; Renata Claro R Amaral; Fernanda O Demitto; Flaviane G Maltempe; Pedro Henrique Canezin; Regiane B L Scodro; Celso V Nakamura; Clarice Queico F Leite; Vera Lúcia D Siqueira; Rosilene F Cardoso
Journal:  Tuberculosis (Edinb)       Date:  2016-01-07       Impact factor: 3.131

3.  Structural mechanism for rifampicin inhibition of bacterial rna polymerase.

Authors:  E A Campbell; N Korzheva; A Mustaev; K Murakami; S Nair; A Goldfarb; S A Darst
Journal:  Cell       Date:  2001-03-23       Impact factor: 41.582

4.  In vitro combinatory activity of piperine and anti-tuberculosis drugs in Mycobacterium tuberculosis.

Authors:  Laíse Adriane Hegeto; Katiany R Caleffi-Ferracioli; Sandra S Nakamura-Vasconcelos; Aryadne Larissa de Almeida; Vanessa Pietrowski Baldin; Celso Vataru Nakamura; Vera Lúcia D Siqueira; Regiane B L Scodro; Rosilene Fressatti Cardoso
Journal:  Tuberculosis (Edinb)       Date:  2018-05-14       Impact factor: 3.131

5.  Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex.

Authors:  Liliana Rodrigues; Diana Machado; Isabel Couto; Leonard Amaral; Miguel Viveiros
Journal:  Infect Genet Evol       Date:  2011-08-17       Impact factor: 3.342

6.  Identification of a novel multidrug efflux pump of Mycobacterium tuberculosis.

Authors:  Olga Danilchanka; Claudia Mailaender; Michael Niederweis
Journal:  Antimicrob Agents Chemother       Date:  2008-05-05       Impact factor: 5.191

7.  BacA, an ABC transporter involved in maintenance of chronic murine infections with Mycobacterium tuberculosis.

Authors:  Pilar Domenech; Hajime Kobayashi; Kristin LeVier; Graham C Walker; Clifton E Barry
Journal:  J Bacteriol       Date:  2008-11-07       Impact factor: 3.490

8.  mmr, a Mycobacterium tuberculosis gene conferring resistance to small cationic dyes and inhibitors.

Authors:  E De Rossi; M Branzoni; R Cantoni; A Milano; G Riccardi; O Ciferri
Journal:  J Bacteriol       Date:  1998-11       Impact factor: 3.490

9.  A Randomized, Controlled, Phase III Clinical Trial to Evaluate the Efficacy and Tolerability of Risorine with Conventional Rifampicin in the Treatment of Newly Diagnosed Pulmonary Tuberculosis Patients.

Authors:  Naresh Patel; K Jagannath; Agam Vora; Mukesh Patel; Anand Patel
Journal:  J Assoc Physicians India       Date:  2017-09

10.  Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis.

Authors:  Diana Machado; David Pires; João Perdigão; Isabel Couto; Isabel Portugal; Marta Martins; Leonard Amaral; Elsa Anes; Miguel Viveiros
Journal:  PLoS One       Date:  2016-02-26       Impact factor: 3.240
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  1 in total

Review 1.  Advances in adjunct therapy against tuberculosis: Deciphering the emerging role of phytochemicals.

Authors:  Samreen Fatima; Anjna Kumari; Ved Prakash Dwivedi
Journal:  MedComm (2020)       Date:  2021-08-05
  1 in total

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