Literature DB >> 3148110

Hydrogen peroxide mediates reperfusion injury in the isolated rat heart.

J M Brown1, L S Terada, M A Grosso, G J Whitman, S E Velasco, A Patt, A H Harken, J E Repine.   

Abstract

In an isolated, normothermic rat heart model (Langendorff, 37 degrees C), dimethylthiourea (DMTU) infusion only during reperfusion reduced both injury and measurable hydrogen peroxide (H2O2) concentrations after global ischemia. Cardiac function was assessed by measurement of ventricular developed pressure (DP). H2O2 was assessed using H2O2 dependent aminotriazole inactivation of myocardial catalase. Depletion of xanthine oxidase by two methods (tungsten or allopurinol inhibition) also improved recovery of function and H2O2 production. The results indicate that XO derived H2O2 contributes to myocardial reperfusion injury.

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Year:  1988        PMID： 3148110     DOI： 10.1007/bf00421052

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  12 in total

1.  Molybdenum deficiency and tungstate inhibition studies.

Authors:  E S HIGGINS; D A RICHERT; W W WESTERFELD
Journal:  J Nutr       Date:  1956-08-10       Impact factor: 4.798

2.  Xanthine oxidase mediates elastase-induced injury to isolated lungs and endothelium.

Authors:  T C Rodell; J C Cheronis; C L Ohnemus; D J Piermattei; J E Repine
Journal:  J Appl Physiol (1985)       Date:  1987-11

3.  Pulmonary oxygen toxicity and ischemia-reperfusion injury. A mechanism in common involving xanthine oxidase and neutrophils.

Authors:  J E Repine; J C Cheronis; T C Rodell; S L Linas; A Patt
Journal:  Am Rev Respir Dis       Date:  1987-08

4.  Cell penetration by exogenous superoxide dismutase.

Authors:  A M Michelson; K Puget
Journal:  Acta Physiol Scand Suppl       Date:  1980

5.  Prevention of free radical-induced myocardial reperfusion injury with allopurinol.

Authors:  J R Stewart; S L Crute; V Loughlin; M L Hess; L J Greenfield
Journal:  J Thorac Cardiovasc Surg       Date:  1985-07       Impact factor: 5.209

6.  Dimethylthiourea consumption reflects H2O2 concentrations and severity of acute lung injury.

Authors:  J H Jackson; C W White; N B Parker; J W Ryan; J E Repine
Journal:  J Appl Physiol (1985)       Date:  1985-12

7.  Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

Authors:  S R Jolly; W J Kane; M B Bailie; G D Abrams; B R Lucchesi
Journal:  Circ Res       Date:  1984-03       Impact factor: 17.367

8.  Xanthine oxidase as a source of free radical damage in myocardial ischemia.

Authors:  D E Chambers; D A Parks; G Patterson; R Roy; J M McCord; S Yoshida; L F Parmley; J M Downey
Journal:  J Mol Cell Cardiol       Date:  1985-02       Impact factor: 5.000

9.  Involvement of hydrogen peroxide and hydroxyl radical in the 'oxygen paradox': reduction of creatine kinase release by catalase, allopurinol or deferoxamine, but not by superoxide dismutase.

Authors:  C L Myers; S J Weiss; M M Kirsh; M Shlafer
Journal:  J Mol Cell Cardiol       Date:  1985-07       Impact factor: 5.000

10.  Xanthine oxidase produces hydrogen peroxide which contributes to reperfusion injury of ischemic, isolated, perfused rat hearts.

Authors:  J M Brown; L S Terada; M A Grosso; G J Whitmann; S E Velasco; A Patt; A H Harken; J E Repine
Journal:  J Clin Invest       Date:  1988-04       Impact factor: 14.808
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  2 in total

1.  Evaluation of the antioxidant potential of Salvia miltiorrhiza ethanol extract in a rat model of ischemia-reperfusion injury.

Authors:  Zengyong Qiao; Jiangwei Ma; Huajin Liu
Journal:  Molecules       Date:  2011-12-02       Impact factor: 4.411

2.  The Protective Effect of Cx43 Protein-Mediated Phosphocreatine on Myocardial Ischemia/Reperfusion Injury.

Authors:  Chen-Xi Wang; Jun-Jun Guo; An-Jie Di; Yu Zhu; Wei-Min Han; An-Ran Cheng; Cheng Li; Rui-Chan Si; Tian-Shu Lan; Ran Zhang; Hong-Li Liu; Guo-Liang Yan
Journal:  Cardiol Res Pract       Date:  2021-01-22       Impact factor: 1.866
  2 in total

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