Literature DB >> 16246038

Leptin: a potential cognitive enhancer?

J Harvey1, L J Shanley, D O'Malley, A J Irving.   

Abstract

It is well documented that the hormone leptin signals information regarding the status of fat stores to hypothalamic nuclei, which in turn control feeding behaviour and body weight. However, leptin and its receptor are widely expressed in many extra-hypothalamic brain regions, including hippocampus, brain stem and cerebellum. Moreover, evidence is accumulating that leptin has other neuronal functions that are unrelated to its effects on energy homeostasis. Indeed a role for leptin in neuronal development has been suggested as leptin-deficient rodents display abnormal brain development and leptin actively participates in the development of the hypothalamus. In the hippocampus, leptin is a potential cognitive enhancer as genetically obese rodents with dysfunctional leptin receptors display impairments in hippocampal synaptic plasticity. Moreover, direct administration of leptin into the hippocampus can facilitate hippocampal LTP (long-term potentiation) in vivo and improve memory processing in mice. At the cellular level, we have also shown that leptin has the capacity to convert short-term potentiation into LTP. Here, we review the data that leptin influences hippocampal synaptic plasticity via enhancing NMDA (N-methyl-D-aspartate) receptor function. We also provide evidence that rapid trafficking of NMDA receptors to the plasma membrane may underlie the effects of leptin on excitatory synaptic strength.

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Year:  2005        PMID: 16246038     DOI: 10.1042/BST20051029

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN: 0300-5127            Impact factor:   5.407


  73 in total

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Journal:  Rev Neurosci       Date:  2010       Impact factor: 4.353

2.  Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and β-amyloid in neurons.

Authors:  Steven J Greco; Ashkan Hamzelou; Jane M Johnston; Mark A Smith; J Wesson Ashford; Nikolaos Tezapsidis
Journal:  Biochem Biophys Res Commun       Date:  2011-09-17       Impact factor: 3.575

Review 3.  Determinants of early life leptin levels and later life degenerative outcomes.

Authors:  Delia-Marina Alexe; Garyfallia Syridou; Eleni Th Petridou
Journal:  Clin Med Res       Date:  2006-12

4.  Metabolic and neurologic consequences of chronic lopinavir/ritonavir administration to C57BL/6 mice.

Authors:  Paul J Pistell; Sunita Gupta; Alecia G Knight; Michelle Domingue; Romina M Uranga; Donald K Ingram; Indu Kheterpal; Carmen Ruiz; Jeffrey N Keller; Annadora J Bruce-Keller
Journal:  Antiviral Res       Date:  2010-10-21       Impact factor: 5.970

5.  Leptin signaling and Alzheimer's disease.

Authors:  Gurdeep Marwarha; Othman Ghribi
Journal:  Am J Neurodegener Dis       Date:  2012-11-18

6.  Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging.

Authors:  Wolfgang Lieb; Alexa S Beiser; Ramachandran S Vasan; Zaldy S Tan; Rhoda Au; Tamara B Harris; Ronenn Roubenoff; Sanford Auerbach; Charles DeCarli; Philip A Wolf; Sudha Seshadri
Journal:  JAMA       Date:  2009-12-16       Impact factor: 56.272

7.  Cognitive impairment following high fat diet consumption is associated with brain inflammation.

Authors:  Paul J Pistell; Christopher D Morrison; Sunita Gupta; Alecia G Knight; Jeffrey N Keller; Donald K Ingram; Annadora J Bruce-Keller
Journal:  J Neuroimmunol       Date:  2009-12-08       Impact factor: 3.478

8.  The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism.

Authors:  Ozlem Bozdagi; Erin Rich; Sophie Tronel; Masato Sadahiro; Kamara Patterson; Matthew L Shapiro; Cristina M Alberini; George W Huntley; Stephen R J Salton
Journal:  J Neurosci       Date:  2008-09-24       Impact factor: 6.167

Review 9.  Obesity and vulnerability of the CNS.

Authors:  Annadora J Bruce-Keller; Jeffrey N Keller; Christopher D Morrison
Journal:  Biochim Biophys Acta       Date:  2008-10-17

10.  Regulation of glutamate receptor trafficking by leptin.

Authors:  Peter R Moult; Jenni Harvey
Journal:  Biochem Soc Trans       Date:  2009-12       Impact factor: 5.407

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