| Literature DB >> 31473301 |
Lysianne Beynel1, Lawrence G Appelbaum1, Bruce Luber2, Courtney A Crowell1, Susan A Hilbig1, Wesley Lim1, Duy Nguyen1, Nicolas A Chrapliwy1, Simon W Davis3, Roberto Cabeza4, Sarah H Lisanby5, Zhi-De Deng6.
Abstract
Online repetitive transcranial magnetic stimulation (rTMS), applied while subjects are performing a task, is widely used to disrupt brain regions underlying cognition. However, online rTMS has also induced "paradoxical enhancement". Given the rapid proliferation of this approach, it is crucial to develop a better understanding of how online stimulation influences cognition, and the optimal parameters to achieve desired effects. To accomplish this goal, a quantitative meta-analysis was performed with random-effects models fitted to reaction time (RT) and accuracy data. The final dataset included 126 studies published between 1998 and 2016, with 244 total effects for reaction times, and 202 for accuracy. Meta-analytically, rTMS at 10 Hz and 20 Hz disrupted accuracy for attention, executive, language, memory, motor, and perception domains, while no effects were found with 1 Hz or 5 Hz. Stimulation applied at and 10 and 20 Hz slowed down RTs in attention and perception tasks. No performance enhancement was found. Meta-regression analysis showed that fMRI-guided targeting and short inter-trial intervals are associated with increased disruptive effects with rTMS. Published by Elsevier Ltd.Entities:
Keywords: Cognition; Meta-analysis; Online rTMS
Mesh：
Year: 2019 PMID： 31473301 PMCID： PMC7654714 DOI： 10.1016/j.neubiorev.2019.08.018
Source DB: PubMed Journal: Neurosci Biobehav Rev ISSN： 0149-7634 Impact factor: 8.989