Yu-Chuen Huang1,2, Ching-Chu Chen1,3, Tzu-Yuan Wang3, Hung Tran The Nguyen4, Yung-Hsiang Chen5, Chia-Ming Wu2, Ya-Wen Chang2, Wen-Ling Liao6,7, Fuu-Jen Tsai8,9. 1. School of Chinese Medicine, China Medical University, Taichung, Taiwan, R.O.C. 2. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C. 3. Division of Endocrinology and Metabolism, Department of Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C. 4. International Master's Program of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C. 5. Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan, R.O.C. 6. Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan, R.O.C. d0704@www.cmuh.org.tw wl0129@mail.cmu.edu.tw. 7. Center for Personalized Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C. 8. Department of Medical Research, Medical Genetics and Pediatrics, China Medical University Hospital, Taichung, Taiwan, R.O.C. d0704@www.cmuh.org.tw wl0129@mail.cmu.edu.tw. 9. Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan, R.O.C.
Abstract
BACKGROUND/AIM: C-Reactive protein (CRP) is a common marker of inflammation. Elevated CRP levels have been associated with increased risk of development of type 2 diabetes mellitus (T2DM). This study aimed to evaluate the association of CRP gene polymorphisms with early-onset T2DM and the effect of genetic variants on CRP level. MATERIALS AND METHODS: In total, 948 individuals with early-onset (n=271) or late-onset (n=677) T2DM were enrolled in the study. Five single-nucleotide polymorphisms (SNPs) in the CRP gene, namely rs3093077, rs2808630, rs1800947, rs11265263, and rs11265265, were selected for genotyping, and CRP levels were measured. RESULTS: Genotypic, allelic, and haplotype frequencies of these five SNPs were not significantly different between patients with early- and those with late-onset. T2DM Higher serum CRP levels were independently associated with the C-allele of rs3093077 and T-allele of rs11265265 (p<0.001). Furthermore, the C-allele of rs3093077 was associated with higher CRP level in both early- (p=0.016) and late-onset (p<0.001) T2DM. CONCLUSION: CRP gene variants may contribute to the risk of early-onset T2DM by affecting the serum CRP level. Copyright
BACKGROUND/AIM: C-Reactive protein (CRP) is a common marker of inflammation. Elevated CRP levels have been associated with increased risk of development of type 2 diabetes mellitus (T2DM). This study aimed to evaluate the association of CRP gene polymorphisms with early-onset T2DM and the effect of genetic variants on CRP level. MATERIALS AND METHODS: In total, 948 individuals with early-onset (n=271) or late-onset (n=677) T2DM were enrolled in the study. Five single-nucleotide polymorphisms (SNPs) in the CRP gene, namely rs3093077, rs2808630, rs1800947, rs11265263, and rs11265265, were selected for genotyping, and CRP levels were measured. RESULTS: Genotypic, allelic, and haplotype frequencies of these five SNPs were not significantly different between patients with early- and those with late-onset. T2DM Higher serum CRP levels were independently associated with the C-allele of rs3093077 and T-allele of rs11265265 (p<0.001). Furthermore, the C-allele of rs3093077 was associated with higher CRP level in both early- (p=0.016) and late-onset (p<0.001) T2DM. CONCLUSION:CRP gene variants may contribute to the risk of early-onset T2DM by affecting the serum CRP level. Copyright
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