Yuzhong Xu1, Minggang Cheng1, Xiong Wang2. 1. Department of Clinical Laboratory, Shenzhen Baoan Hospital, Southern Medical University, Shenzhen 518000, China. 2. Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science, Wuhan 430030, China.
Abstract
OBJECTIVE: The T allele of C-reactive protein (CRP) +1444C/T (rs1130864) polymorphism was associated with increased risk for some inflammatory conditions. The objective of the study was to explore the association between the CRP +1444C/T polymorphism with the susceptibility to pulmonary tuberculosis (PTB) in a Chinese population. METHODS: This case-control study enrolled 480 PTB patients and 480 healthy controls. The CRP +1444C/T polymorphism was determined using Sanger sequencing. The odds ratio (OR) and 95% confidence interval (CI) were assessed to examine the strength of genetic correlation. RESULTS: The genotype and allele frequencies of PTB patients differed from controls (CT vs. CC, OR = 1.924, 95% CI: 1.099-3.371, adjusted P value = 0.022; T vs. C, OR = 1.884, 95% CI: 1.085-3.273, adjusted P value = 0.024). Stratified analysis by sex found that PTB patients' genotype and allele frequencies differed from controls in the male subgroup but not the female subgroup. CONCLUSION: In conclusion, the minor T allele of CRP +1444C/T polymorphism was associated with increased PTB risk.
OBJECTIVE: The T allele of C-reactive protein (CRP) +1444C/T (rs1130864) polymorphism was associated with increased risk for some inflammatory conditions. The objective of the study was to explore the association between the CRP +1444C/T polymorphism with the susceptibility to pulmonary tuberculosis (PTB) in a Chinese population. METHODS: This case-control study enrolled 480 PTB patients and 480 healthy controls. The CRP +1444C/T polymorphism was determined using Sanger sequencing. The odds ratio (OR) and 95% confidence interval (CI) were assessed to examine the strength of genetic correlation. RESULTS: The genotype and allele frequencies of PTB patients differed from controls (CT vs. CC, OR = 1.924, 95% CI: 1.099-3.371, adjusted P value = 0.022; T vs. C, OR = 1.884, 95% CI: 1.085-3.273, adjusted P value = 0.024). Stratified analysis by sex found that PTB patients' genotype and allele frequencies differed from controls in the male subgroup but not the female subgroup. CONCLUSION: In conclusion, the minor T allele of CRP +1444C/T polymorphism was associated with increased PTB risk.
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