Literature DB >> 3146975

Influence of interferon-gamma and extracellular tryptophan on indoleamine 2,3-dioxygenase activity in T24 cells as determined by a non-radiometric assay.

E R Werner1, G Werner-Felmayer, D Fuchs, A Hausen, G Reibnegger, H Wachter.   

Abstract

The indoleamine 2,3-dioxygenase (EC 1.13.11.17) activity in human T24 cells has been investigated in cell extracts by using a non-radioactive assay. It is enhanced in a dose-dependent manner up to 25-fold by interferon-gamma. The maximum reaction velocity is increased rather than the Km, which remains at 4 mumol/l. Induction of activity starts 3 h after stimulation and reaches a plateau at 21-48 h. Decreased stimulation was observed in the presence of high L-tryptophan concentrations.

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Year:  1988        PMID： 3146975      PMCID： PMC1135443          DOI： 10.1042/bj2560537

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  Induction of tryptophan degradation in vitro and in vivo: a gamma-interferon-stimulated activity.

Authors:  G I Byrne; L K Lehmann; J G Kirschbaum; E C Borden; C M Lee; R R Brown
Journal:  J Interferon Res       Date:  1986-08

2.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

3.  Characterization of an indoleamine 2,3-dioxygenase induced by gamma-interferon in cultured human fibroblasts.

Authors:  E R Pfefferkorn; S Rebhun; M Eckel
Journal:  J Interferon Res       Date:  1986-06

4.  Established cell line of urinary bladder carcinoma (T24) containing tumour-specific antigen.

Authors:  J Bubeník; M Baresová; V Viklický; J Jakoubková; H Sainerová; J Donner
Journal:  Int J Cancer       Date:  1973-05       Impact factor: 7.396

5.  New degradative routes of 5-hydroxytryptophan and serotonin by intestinal tryptophan 2,3-dioxygenase.

Authors:  F Hirata; O Hayaishi
Journal:  Biochem Biophys Res Commun       Date:  1972-06-09       Impact factor: 3.575

6.  Tryptophan oxygenase and tryptophan metabolism in endotoxin-poisoned and allopurinol-treated mice.

Authors:  R J Moon
Journal:  Biochim Biophys Acta       Date:  1971-02-23

7.  A simple cytochemical technique for demonstration of DNA in cells infected with mycoplasmas and viruses.

Authors:  W C Russell; C Newman; D H Williamson
Journal:  Nature       Date:  1975-02-06       Impact factor: 49.962

8.  Tryptophan pyrrolase of rabbit intestine. D- and L-tryptophan-cleaving enzyme or enzymes.

Authors:  S Yamamoto; O Hayaishi
Journal:  J Biol Chem       Date:  1967-11-25       Impact factor: 5.157

9.  Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.

Authors:  E R Pfefferkorn
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

10.  Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.

Authors:  Y Ozaki; M P Edelstein; D S Duch
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205
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  4 in total

1.  Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma.

Authors:  E R Werner; G Werner-Felmayer; D Fuchs; A Hausen; G Reibnegger; H Wachter
Journal:  Biochem J       Date:  1989-09-15       Impact factor: 3.857

2.  Increased hippocampal nitric oxide synthase activity and stress responsiveness after imipramine discontinuation: role of 5HT 2A/C-receptors.

Authors:  Brian H Harvey; Renché Retief; Ané Korff; Gregers Wegener
Journal:  Metab Brain Dis       Date:  2006-07-22       Impact factor: 3.584

Review 3.  Substrate and cofactor requirements of indoleamine 2,3-dioxygenase in interferon-gamma-treated cells: utilization of oxygen rather than superoxide.

Authors:  Ernst R Werner; G Werner-Felmayer
Journal:  Curr Drug Metab       Date:  2007-04       Impact factor: 3.731

Review 4.  Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19.

Authors:  Jéssica Araujo da Paixão de Oliveira; Mariana Martins de Athaide; Atta Ur Rahman; Mayara Garcia de Mattos Barbosa; Marcia Maria Jardim; Milton Ozório Moraes; Roberta Olmo Pinheiro
Journal:  Front Cell Infect Microbiol       Date:  2022-02-24       Impact factor: 5.293
  4 in total

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