Rodolfo Mastropasqua1,2, Rossella D'Aloisio3, Luca Di Antonio4, Emanuele Erroi4, Enrico Borrelli5, Federica Evangelista4, Giada D'Onofrio4, Marta Di Nicola6, Giuseppe Di Martino7, Lisa Toto4. 1. Vitreoretinal Unit, Bristol Eye Hospital, University of Bristol, Bristol, UK. 2. Eye Clinic, Polytechnic University of Marche, 60126, Ancona, Italy. 3. Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy. ross.daloisio@gmail.com. 4. Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy. 5. Department of Ophthalmology, University Vita Salute, IRCCS Ospedale San Raffaele, 20132, Milan, Italy. 6. Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, University "G. d'Annunzio" Chieti-Pescara, 66100, Chieti, Italy. 7. Department of Medicine and Science of Ageing, School of Hygiene and Preventive Medicine, University G. d'Annunzio Chieti-Pescara, 66100, Chieti, Italy.
Abstract
AIMS: To evaluate superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) perfusion in macular and near/mid periphery regions in diabetic patients using widefield swept-source optical coherence tomography angiography (WSS-OCTA). METHODS: Ninety-four diabetic patients (94 eyes) classified as diabetics without diabetic retinopathy (no DR) (25 eyes), mild DR (23 eyes), moderate/severe DR (26 eyes), proliferative DR (20 eyes) and a control group of 25 healthy subjects (25 eyes) were imaged with the WSS-OCTA system (PLEX Elite 9000, Carl Zeiss Meditec Inc., Dublin, CA, USA). Quantitative analysis was performed in the macular and peripheral regions. The main outcome measures were perfusion density (PD) and vessel length density of SCP, DCP and CC. RESULTS: Peripheral retina (all sectors) showed lower SCP and DCP PD compared to the macular region (p < 0.001). In diabetics without DR and DR in different stages, SCP and DCP PD significantly decreased at advancing stages of DR (p < 0.001). At DCP level, central PD was significantly directly related to peripheral PD (superior, R = 0.682 and 0.479; temporal, R = 0.918 and 0.554; inferior, R = 0.711). A good sensitivity and an excellent specificity were found in terms of prediction of disease worsening, especially for central and temporal sectors in all plexuses and for all sectors both central and peripheral of DCP. CONCLUSIONS: The widefield OCTA is useful for the study of central and peripheral retina in diabetic patients with or without diabetic retinopathy, assessing good correlation between central and peripheral retina.
AIMS: To evaluate superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) perfusion in macular and near/mid periphery regions in diabeticpatients using widefield swept-source optical coherence tomography angiography (WSS-OCTA). METHODS: Ninety-four diabeticpatients (94 eyes) classified as diabetics without diabetic retinopathy (no DR) (25 eyes), mild DR (23 eyes), moderate/severe DR (26 eyes), proliferative DR (20 eyes) and a control group of 25 healthy subjects (25 eyes) were imaged with the WSS-OCTA system (PLEX Elite 9000, Carl Zeiss Meditec Inc., Dublin, CA, USA). Quantitative analysis was performed in the macular and peripheral regions. The main outcome measures were perfusion density (PD) and vessel length density of SCP, DCP and CC. RESULTS: Peripheral retina (all sectors) showed lower SCP and DCPPD compared to the macular region (p < 0.001). In diabetics without DR and DR in different stages, SCP and DCPPD significantly decreased at advancing stages of DR (p < 0.001). At DCP level, central PD was significantly directly related to peripheral PD (superior, R = 0.682 and 0.479; temporal, R = 0.918 and 0.554; inferior, R = 0.711). A good sensitivity and an excellent specificity were found in terms of prediction of disease worsening, especially for central and temporal sectors in all plexuses and for all sectors both central and peripheral of DCP. CONCLUSIONS: The widefield OCTA is useful for the study of central and peripheral retina in diabeticpatients with or without diabetic retinopathy, assessing good correlation between central and peripheral retina.
Authors: Marion R Munk; Amir H Kashani; Ramin Tadayoni; Jean-Francois Korobelnik; Sebastian Wolf; Francesco Pichi; Adrian Koh; Akihiro Ishibazawa; Alain Gaudric; Anat Loewenstein; Bruno Lumbroso; Daniela Ferrara; David Sarraf; David T Wong; Dimitra Skondra; Francisco J Rodriguez; Giovanni Staurenghi; Ian Pearce; Judy E Kim; K Bailey Freund; Maurizio Battaglia Parodi; Nadia K Waheed; Richard Rosen; Richard F Spaide; Shintaro Nakao; SriniVas Sadda; Stela Vujosevic; Tien Yin Wong; Toshinori Murata; Usha Chakravarthy; Yuichiro Ogura; Wolfgang Huf; Meng Tian Journal: Ophthalmol Retina Date: 2022-02-22
Authors: Inês Preguiça; André Alves; Sara Nunes; Pedro Gomes; Rosa Fernandes; Sofia D Viana; Flávio Reis Journal: Nutrients Date: 2020-01-18 Impact factor: 5.717
Authors: Rodolfo Mastropasqua; Rossella D'Aloisio; Chiara De Nicola; Giada Ferro; Alfonso Senatore; Daniele Libertini; Guido Di Marzio; Marta Di Nicola; Giuseppe Di Martino; Luca Di Antonio; Lisa Toto Journal: Diagnostics (Basel) Date: 2020-01-19