Literature DB >> 31456890

Recent trends in two-photon auto-fluorescence lifetime imaging (2P-FLIM) and its biomedical applications.

Harsh Ranawat1, Sagnik Pal1, Nirmal Mazumder1.   

Abstract

Two photon fluorescence microscopy and the numerous technical advances to it have served as valuable tools in biomedical research. The fluorophores (exogenous or endogenous) absorb light and emit lower energy photons than the absorption energy and the emission (fluorescence) signal is measured using a fluorescence decay graph. Additionally, high spatial resolution images can be acquired in two photon fluorescence lifetime imaging (2P-FLIM) with improved penetration depth which helps in detection of fluorescence signal in vivo. 2P-FLIM is a non-invasive imaging technique in order to visualize cellular metabolic, by tracking intrinsic fluorophores present in it, such as nicotinamide adenine dinucleotide, flavin adenine dinucleotide and tryptophan etc. 2P-FLIM of these molecules enable the visualization of metabolic alterations, non-invasively. This comprehensive review discusses the numerous applications of 2P-FLIM towards cancer, neuro-degenerative, infectious diseases, and wound healing.

Entities:  

Keywords:  Flavin adenine dinucleotide (FAD); Fluorescence lifetime imaging microscopy (FLIM); Nicotinamide adenine dinucleotide hydrogen (NADH); Two-photon excitation

Year:  2019        PMID： 31456890      PMCID： PMC6694381          DOI： 10.1007/s13534-019-00119-7

Source DB:  PubMed          Journal:  Biomed Eng Lett        ISSN： 2093-9868


  95 in total

1.  A tool to assess clinical signs and symptoms of localized infection in chronic wounds: development and reliability.

Authors:  S E Gardner; R A Frantz; C Troia; S Eastman; M MacDonald; K Buresh; D Healy
Journal:  Ostomy Wound Manage       Date:  2001-01       Impact factor: 2.629

2.  Fluorescence lifetime imaging for the two-photon microscope: time-domain and frequency-domain methods.

Authors:  Enrico Gratton; Sophie Breusegem; Jason Sutin; Qiaoqiao Ruan; Nicholas Barry
Journal:  J Biomed Opt       Date:  2003-07       Impact factor: 3.170

3.  Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques.

Authors:  Brian J Bacskai; Jesse Skoch; Gregory A Hickey; Racquel Allen; Bradley T Hyman
Journal:  J Biomed Opt       Date:  2003-07       Impact factor: 3.170

4.  Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescence.

Authors:  Aikaterini Zoumi; Alvin Yeh; Bruce J Tromberg
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-12       Impact factor: 11.205

Review 5.  Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms.

Authors:  Paul J Campagnola; Leslie M Loew
Journal:  Nat Biotechnol       Date:  2003-11       Impact factor: 54.908

6.  Characterization of collagen orientation in human dermis by two-dimensional second-harmonic-generation polarimetry.

Authors:  Takeshi Yasui; Yoshiyuki Tohno; Tsutomu Araki
Journal:  J Biomed Opt       Date:  2004 Mar-Apr       Impact factor: 3.170

7.  Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.

Authors:  William E Klunk; Brian J Bacskai; Chester A Mathis; Stephen T Kajdasz; Megan E McLellan; Matthew P Frosch; Manik L Debnath; Daniel P Holt; Yanming Wang; Bradley T Hyman
Journal:  J Neuropathol Exp Neurol       Date:  2002-09       Impact factor: 3.685

Review 8.  Parkinson's disease: mechanisms and models.

Authors:  William Dauer; Serge Przedborski
Journal:  Neuron       Date:  2003-09-11       Impact factor: 17.173

9.  Fluorescence lifetime imaging of unstained tissues: early results in human breast cancer.

Authors:  Paul J Tadrous; Jan Siegel; Paul M W French; Sami Shousha; El-Nasir Lalani; Gordon W H Stamp
Journal:  J Pathol       Date:  2003-03       Impact factor: 7.996

10.  Fluorescence lifetime-resolved pH imaging of living cells.

Authors:  Hai-Jui Lin; Petr Herman; Joseph R Lakowicz
Journal:  Cytometry A       Date:  2003-04       Impact factor: 4.355
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  7 in total

1.  Intravital two-photon imaging and quantification of hepatic steatosis and fibrosis in a live small animal model.

Authors:  Jieun Moon; Jehwi Jeon; Eunji Kong; Sujung Hong; Jingu Lee; Eun Kyung Lee; Pilhan Kim
Journal:  Biomed Opt Express       Date:  2021-12-01       Impact factor: 3.732

2.  Performance comparison of high-speed photoacoustic microscopy: opto-ultrasound combiner versus ring-shaped ultrasound transducer.

Authors:  Hyojin Kim; Jin Young Kim; Seonghee Cho; Joongho Ahn; Yeonggeun Kim; Hyungham Kim; Chulhong Kim
Journal:  Biomed Eng Lett       Date:  2022-03-02

3.  Luminescence lifetime imaging of three-dimensional biological objects.

Authors:  Ruslan I Dmitriev; Xavier Intes; Margarida M Barroso
Journal:  J Cell Sci       Date:  2021-05-07       Impact factor: 5.285

4.  Automated Extraction of Skin Wound Healing Biomarkers From In Vivo Label-Free Multiphoton Microscopy Using Convolutional Neural Networks.

Authors:  Jake D Jones; Marcos R Rodriguez; Kyle P Quinn
Journal:  Lasers Surg Med       Date:  2021-01-13

Review 5.  FLIM as a Promising Tool for Cancer Diagnosis and Treatment Monitoring.

Authors:  Yuzhen Ouyang; Yanping Liu; Zhiming M Wang; Zongwen Liu; Minghua Wu
Journal:  Nanomicro Lett       Date:  2021-06-03

Review 6.  Label-Free Multiphoton Microscopy for the Detection and Monitoring of Calcific Aortic Valve Disease.

Authors:  Ishita Tandon; Kyle P Quinn; Kartik Balachandran
Journal:  Front Cardiovasc Med       Date:  2021-06-11

7.  Retinal Organoids Long-Term Functional Characterization Using Two-Photon Fluorescence Lifetime and Hyperspectral Microscopy.

Authors:  Yuntian Xue; Andrew W Browne; William C Tang; Jeffrey Delgado; Bryce T McLelland; Gabriel Nistor; Jacqueline T Chen; Kaylee Chew; Nicolas Lee; Hans S Keirstead; Magdalene J Seiler
Journal:  Front Cell Neurosci       Date:  2021-12-10       Impact factor: 5.505
  7 in total

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