BACKGROUND AND AIM: Migraine is a highly prevalent and disabling neurological disorder associated with a wide range of psychiatric comorbidities. Studies have revealed that those with migraine headache and coexisting psychiatric disorders have poorer treatment outcomes and increased disability. The study aims to establish the prevalence, correlates, and comorbidities of migraine headache among the multi-ethnic Asian population in Singapore. METHOD: Data were extracted from the Singapore Mental Health Study 2016 (SMHS 2016), a cross-sectional epidemiological survey of a nationally representative sample. Face-to-face interviews were completed with 6126 participants between 2016 and 2017. The data relating to chronic medical conditions, psychiatric conditions, and 30-day functioning and disability were captured using the World Mental Health Composite International Diagnostic Interview (CIDI) version 3.0. RESULTS: The lifetime prevalence for migraine headache in the Singapore general population was 8.2%. Malay ethnicity (versus Chinese), female gender (versus male), and diploma holders (versus university) were significantly more likely to experience migraine headache. Participants belonging to the older age group (65 years and above versus 18-34 years of age), and those who were economically inactive (versus employed) were less likely to experience migraine headache. The mean age of onset for migraine was 26.4 years (SD = 11.1). Poisson regression analyses showed that migraine headache was also significantly associated with psychiatric conditions such as major depressive disorder (MDD) (prevalence ratio (PR), 1.80; 95% CI, 1.25-2.58), bipolar disorder (BD) (PR, 3.55; 95% CI, 2.29-5.51), generalized anxiety disorder (GAD) (PR, 2.04; 95% CI, 1.12-3.69), obsessive compulsive disorder (OCD) (PR, 2.20; 95% CI, 1.49-3.26), and alcohol use disorder (AUD) (PR, 1.93; 95% CI, 1.20-3.08). Those with migraine headache were significantly associated with poor functioning and disability compared to those without migraine headache. CONCLUSIONS AND DISCUSSION: Our study showed significant associations between migraine headache and psychiatric disorders, as well as with role functioning and disability. The findings of our study emphasise the need for screening for psychiatric comorbidity among those with migraine and the development of appropriate interventions for this group.
BACKGROUND AND AIM: Migraine is a highly prevalent and disabling neurological disorder associated with a wide range of psychiatric comorbidities. Studies have revealed that those with migraine headache and coexisting psychiatric disorders have poorer treatment outcomes and increased disability. The study aims to establish the prevalence, correlates, and comorbidities of migraine headache among the multi-ethnic Asian population in Singapore. METHOD: Data were extracted from the Singapore Mental Health Study 2016 (SMHS 2016), a cross-sectional epidemiological survey of a nationally representative sample. Face-to-face interviews were completed with 6126 participants between 2016 and 2017. The data relating to chronic medical conditions, psychiatric conditions, and 30-day functioning and disability were captured using the World Mental Health Composite International Diagnostic Interview (CIDI) version 3.0. RESULTS: The lifetime prevalence for migraine headache in the Singapore general population was 8.2%. Malay ethnicity (versus Chinese), female gender (versus male), and diploma holders (versus university) were significantly more likely to experience migraine headache. Participants belonging to the older age group (65 years and above versus 18-34 years of age), and those who were economically inactive (versus employed) were less likely to experience migraine headache. The mean age of onset for migraine was 26.4 years (SD = 11.1). Poisson regression analyses showed that migraine headache was also significantly associated with psychiatric conditions such as major depressive disorder (MDD) (prevalence ratio (PR), 1.80; 95% CI, 1.25-2.58), bipolar disorder (BD) (PR, 3.55; 95% CI, 2.29-5.51), generalized anxiety disorder (GAD) (PR, 2.04; 95% CI, 1.12-3.69), obsessive compulsive disorder (OCD) (PR, 2.20; 95% CI, 1.49-3.26), and alcohol use disorder (AUD) (PR, 1.93; 95% CI, 1.20-3.08). Those with migraine headache were significantly associated with poor functioning and disability compared to those without migraine headache. CONCLUSIONS AND DISCUSSION: Our study showed significant associations between migraine headache and psychiatric disorders, as well as with role functioning and disability. The findings of our study emphasise the need for screening for psychiatric comorbidity among those with migraine and the development of appropriate interventions for this group.
Authors: Verneri Anttila; Brendan Bulik-Sullivan; Hilary K Finucane; Raymond K Walters; Jose Bras; Laramie Duncan; Valentina Escott-Price; Guido J Falcone; Padhraig Gormley; Rainer Malik; Nikolaos A Patsopoulos; Stephan Ripke; Zhi Wei; Dongmei Yu; Phil H Lee; Patrick Turley; Benjamin Grenier-Boley; Vincent Chouraki; Yoichiro Kamatani; Claudine Berr; Luc Letenneur; Didier Hannequin; Philippe Amouyel; Anne Boland; Jean-François Deleuze; Emmanuelle Duron; Badri N Vardarajan; Christiane Reitz; Alison M Goate; Matthew J Huentelman; M Ilyas Kamboh; Eric B Larson; Ekaterina Rogaeva; Peter St George-Hyslop; Hakon Hakonarson; Walter A Kukull; Lindsay A Farrer; Lisa L Barnes; Thomas G Beach; F Yesim Demirci; Elizabeth Head; Christine M Hulette; Gregory A Jicha; John S K Kauwe; Jeffrey A Kaye; James B Leverenz; Allan I Levey; Andrew P Lieberman; Vernon S Pankratz; Wayne W Poon; Joseph F Quinn; Andrew J Saykin; Lon S Schneider; Amanda G Smith; Joshua A Sonnen; Robert A Stern; Vivianna M Van Deerlin; Linda J Van Eldik; Denise Harold; Giancarlo Russo; David C Rubinsztein; Anthony Bayer; Magda Tsolaki; Petra Proitsi; Nick C Fox; Harald Hampel; Michael J Owen; Simon Mead; Peter Passmore; Kevin Morgan; Markus M Nöthen; Martin Rossor; Michelle K Lupton; Per Hoffmann; Johannes Kornhuber; Brian Lawlor; Andrew McQuillin; Ammar Al-Chalabi; Joshua C Bis; Agustin Ruiz; Mercè Boada; Sudha Seshadri; Alexa Beiser; Kenneth Rice; Sven J van der Lee; Philip L De Jager; Daniel H Geschwind; Matthias Riemenschneider; Steffi Riedel-Heller; Jerome I Rotter; Gerhard Ransmayr; Bradley T Hyman; Carlos Cruchaga; Montserrat Alegret; Bendik Winsvold; Priit Palta; Kai-How Farh; Ester Cuenca-Leon; Nicholas Furlotte; Tobias Kurth; Lannie Ligthart; Gisela M Terwindt; Tobias Freilinger; Caroline Ran; Scott D Gordon; Guntram Borck; Hieab H H Adams; Terho Lehtimäki; Juho Wedenoja; Julie E Buring; Markus Schürks; Maria Hrafnsdottir; Jouke-Jan Hottenga; Brenda Penninx; Ville Artto; Mari Kaunisto; Salli Vepsäläinen; Nicholas G Martin; Grant W Montgomery; Mitja I Kurki; Eija Hämäläinen; Hailiang Huang; Jie Huang; Cynthia Sandor; Caleb Webber; Bertram Muller-Myhsok; Stefan Schreiber; Veikko Salomaa; Elizabeth Loehrer; Hartmut Göbel; Alfons Macaya; Patricia Pozo-Rosich; Thomas Hansen; Thomas Werge; Jaakko Kaprio; Andres Metspalu; Christian Kubisch; Michel D Ferrari; Andrea C Belin; Arn M J M van den Maagdenberg; John-Anker Zwart; Dorret Boomsma; Nicholas Eriksson; Jes Olesen; Daniel I Chasman; Dale R Nyholt; Andreja Avbersek; Larry Baum; Samuel Berkovic; Jonathan Bradfield; Russell J Buono; Claudia B Catarino; Patrick Cossette; Peter De Jonghe; Chantal Depondt; Dennis Dlugos; Thomas N Ferraro; Jacqueline French; Helle Hjalgrim; Jennifer Jamnadas-Khoda; Reetta Kälviäinen; Wolfram S Kunz; Holger Lerche; Costin Leu; Dick Lindhout; Warren Lo; Daniel Lowenstein; Mark McCormack; Rikke S Møller; Anne Molloy; Ping-Wing Ng; Karen Oliver; Michael Privitera; Rodney Radtke; Ann-Kathrin Ruppert; Thomas Sander; Steven Schachter; Christoph Schankin; Ingrid Scheffer; Susanne Schoch; Sanjay M Sisodiya; Philip Smith; Michael Sperling; Pasquale Striano; Rainer Surges; G Neil Thomas; Frank Visscher; Christopher D Whelan; Federico Zara; Erin L Heinzen; Anthony Marson; Felicitas Becker; Hans Stroink; Fritz Zimprich; Thomas Gasser; Raphael Gibbs; Peter Heutink; Maria Martinez; Huw R Morris; Manu Sharma; Mina Ryten; Kin Y Mok; Sara Pulit; Steve Bevan; Elizabeth Holliday; John Attia; Thomas Battey; Giorgio Boncoraglio; Vincent Thijs; Wei-Min Chen; Braxton Mitchell; Peter Rothwell; Pankaj Sharma; Cathie Sudlow; Astrid Vicente; Hugh Markus; Christina Kourkoulis; Joana Pera; Miriam Raffeld; Scott Silliman; Vesna Boraska Perica; Laura M Thornton; Laura M Huckins; N William Rayner; Cathryn M Lewis; Monica Gratacos; Filip Rybakowski; Anna Keski-Rahkonen; Anu Raevuori; James I Hudson; Ted Reichborn-Kjennerud; Palmiero Monteleone; Andreas Karwautz; Katrin Mannik; Jessica H Baker; Julie K O'Toole; Sara E Trace; Oliver S P Davis; Sietske G Helder; Stefan Ehrlich; Beate Herpertz-Dahlmann; Unna N Danner; Annemarie A van Elburg; Maurizio Clementi; Monica Forzan; Elisa Docampo; Jolanta Lissowska; Joanna Hauser; Alfonso Tortorella; Mario Maj; Fragiskos Gonidakis; Konstantinos Tziouvas; Hana Papezova; Zeynep Yilmaz; Gudrun Wagner; Sarah Cohen-Woods; Stefan Herms; Antonio Julià; Raquel Rabionet; Danielle M Dick; Samuli Ripatti; Ole A Andreassen; Thomas Espeseth; Astri J Lundervold; Vidar M Steen; Dalila Pinto; Stephen W Scherer; Harald Aschauer; Alexandra Schosser; Lars Alfredsson; Leonid Padyukov; Katherine A Halmi; James Mitchell; Michael Strober; Andrew W Bergen; Walter Kaye; Jin Peng Szatkiewicz; Bru Cormand; Josep Antoni Ramos-Quiroga; Cristina Sánchez-Mora; Marta Ribasés; Miguel Casas; Amaia Hervas; Maria Jesús Arranz; Jan Haavik; Tetyana Zayats; Stefan Johansson; Nigel Williams; Astrid Dempfle; Aribert Rothenberger; Jonna Kuntsi; Robert D Oades; Tobias Banaschewski; Barbara Franke; Jan K Buitelaar; Alejandro Arias Vasquez; Alysa E Doyle; Andreas Reif; Klaus-Peter Lesch; Christine Freitag; Olga Rivero; Haukur Palmason; Marcel Romanos; Kate Langley; Marcella Rietschel; Stephanie H Witt; Soeren Dalsgaard; Anders D Børglum; Irwin Waldman; Beth Wilmot; Nikolas Molly; Claiton H D Bau; Jennifer Crosbie; Russell Schachar; Sandra K Loo; James J McGough; Eugenio H Grevet; Sarah E Medland; Elise Robinson; Lauren A Weiss; Elena Bacchelli; Anthony Bailey; Vanessa Bal; Agatino Battaglia; Catalina Betancur; Patrick Bolton; Rita Cantor; Patrícia Celestino-Soper; Geraldine Dawson; Silvia De Rubeis; Frederico Duque; Andrew Green; Sabine M Klauck; Marion Leboyer; Pat Levitt; Elena Maestrini; Shrikant Mane; Daniel Moreno- De-Luca; Jeremy Parr; Regina Regan; Abraham Reichenberg; Sven Sandin; Jacob Vorstman; Thomas Wassink; Ellen Wijsman; Edwin Cook; Susan Santangelo; Richard Delorme; Bernadette Rogé; Tiago Magalhaes; Dan Arking; Thomas G Schulze; Robert C Thompson; Jana Strohmaier; Keith Matthews; Ingrid Melle; Derek Morris; Douglas Blackwood; Andrew McIntosh; Sarah E Bergen; Martin Schalling; Stéphane Jamain; Anna Maaser; Sascha B Fischer; Céline S Reinbold; Janice M Fullerton; José Guzman-Parra; Fermin Mayoral; Peter R Schofield; Sven Cichon; Thomas W Mühleisen; Franziska Degenhardt; Johannes Schumacher; Michael Bauer; Philip B Mitchell; Elliot S Gershon; John Rice; James B Potash; Peter P Zandi; Nick Craddock; I Nicol Ferrier; Martin Alda; Guy A Rouleau; Gustavo Turecki; Roel Ophoff; Carlos Pato; Adebayo Anjorin; Eli Stahl; Markus Leber; Piotr M Czerski; Cristiana Cruceanu; Ian R Jones; Danielle Posthuma; Till F M Andlauer; Andreas J Forstner; Fabian Streit; Bernhard T Baune; Tracy Air; Grant Sinnamon; Naomi R Wray; Donald J MacIntyre; David Porteous; Georg Homuth; Margarita Rivera; Jakob Grove; Christel M Middeldorp; Ian Hickie; Michele Pergadia; Divya Mehta; Johannes H Smit; Rick Jansen; Eco de Geus; Erin Dunn; Qingqin S Li; Matthias Nauck; Robert A Schoevers; Aartjan Tf Beekman; James A Knowles; Alexander Viktorin; Paul Arnold; Cathy L Barr; Gabriel Bedoya-Berrio; O Joseph Bienvenu; Helena Brentani; Christie Burton; Beatriz Camarena; Carolina Cappi; Danielle Cath; Maria Cavallini; Daniele Cusi; Sabrina Darrow; Damiaan Denys; Eske M Derks; Andrea Dietrich; Thomas Fernandez; Martijn Figee; Nelson Freimer; Gloria Gerber; Marco Grados; Erica Greenberg; Gregory L Hanna; Andreas Hartmann; Matthew E Hirschtritt; Pieter J Hoekstra; Alden Huang; Chaim Huyser; Cornelia Illmann; Michael Jenike; Samuel Kuperman; Bennett Leventhal; Christine Lochner; Gholson J Lyon; Fabio Macciardi; Marcos Madruga-Garrido; Irene A Malaty; Athanasios Maras; Lauren McGrath; Eurípedes C Miguel; Pablo Mir; Gerald Nestadt; Humberto Nicolini; Michael S Okun; Andrew Pakstis; Peristera Paschou; John Piacentini; Christopher Pittenger; Kerstin Plessen; Vasily Ramensky; Eliana M Ramos; Victor Reus; Margaret A Richter; Mark A Riddle; Mary M Robertson; Veit Roessner; Maria Rosário; Jack F Samuels; Paul Sandor; Dan J Stein; Fotis Tsetsos; Filip Van Nieuwerburgh; Sarah Weatherall; Jens R Wendland; Tomasz Wolanczyk; Yulia Worbe; Gwyneth Zai; Fernando S Goes; Nicole McLaughlin; Paul S Nestadt; Hans-Jorgen Grabe; Christel Depienne; Anuar Konkashbaev; Nuria Lanzagorta; Ana Valencia-Duarte; Elvira Bramon; Nancy Buccola; Wiepke Cahn; Murray Cairns; Siow A Chong; David Cohen; Benedicto Crespo-Facorro; James Crowley; Michael Davidson; Lynn DeLisi; Timothy Dinan; Gary Donohoe; Elodie Drapeau; Jubao Duan; Lieuwe Haan; David Hougaard; Sena Karachanak-Yankova; Andrey Khrunin; Janis Klovins; Vaidutis Kučinskas; Jimmy Lee Chee Keong; Svetlana Limborska; Carmel Loughland; Jouko Lönnqvist; Brion Maher; Manuel Mattheisen; Colm McDonald; Kieran C Murphy; Igor Nenadic; Jim van Os; Christos Pantelis; Michele Pato; Tracey Petryshen; Digby Quested; Panos Roussos; Alan R Sanders; Ulrich Schall; Sibylle G Schwab; Kang Sim; Hon-Cheong So; Elisabeth Stögmann; Mythily Subramaniam; Draga Toncheva; John Waddington; James Walters; Mark Weiser; Wei Cheng; Robert Cloninger; David Curtis; Pablo V Gejman; Frans Henskens; Morten Mattingsdal; Sang-Yun Oh; Rodney Scott; Bradley Webb; Gerome Breen; Claire Churchhouse; Cynthia M Bulik; Mark Daly; Martin Dichgans; Stephen V Faraone; Rita Guerreiro; Peter Holmans; Kenneth S Kendler; Bobby Koeleman; Carol A Mathews; Alkes Price; Jeremiah Scharf; Pamela Sklar; Julie Williams; Nicholas W Wood; Chris Cotsapas; Aarno Palotie; Jordan W Smoller; Patrick Sullivan; Jonathan Rosand; Aiden Corvin; Benjamin M Neale; Jonathan M Schott; Richard Anney; Josephine Elia; Maria Grigoroiu-Serbanescu; Howard J Edenberg; Robin Murray Journal: Science Date: 2018-06-22 Impact factor: 47.728
Authors: Svetlana Simić; Tamara Rabi-Žikić; José R Villar; José Luis Calvo-Rolle; Dragan Simić; Svetislav D Simić Journal: Int J Environ Res Public Health Date: 2020-09-22 Impact factor: 3.390