| Literature DB >> 29930110 |
Verneri Anttila1,2,3, Brendan Bulik-Sullivan4,3, Hilary K Finucane2,3,5,6, Raymond K Walters4,2,3, Jose Bras7,8, Laramie Duncan4,2,3,9, Valentina Escott-Price10,11, Guido J Falcone12,13,14, Padhraig Gormley4,2,3,12, Rainer Malik15, Nikolaos A Patsopoulos3,16, Stephan Ripke4,2,3,17, Zhi Wei18, Dongmei Yu2,12, Phil H Lee2,12, Patrick Turley4,3, Benjamin Grenier-Boley19,20,21, Vincent Chouraki19,20,21,22, Yoichiro Kamatani23,24, Claudine Berr25,26,27, Luc Letenneur28,29, Didier Hannequin30,31, Philippe Amouyel19,20,21,22, Anne Boland32, Jean-François Deleuze32, Emmanuelle Duron33,34, Badri N Vardarajan35, Christiane Reitz36, Alison M Goate37, Matthew J Huentelman38, M Ilyas Kamboh39, Eric B Larson40,41, Ekaterina Rogaeva42, Peter St George-Hyslop42,43, Hakon Hakonarson44,45,46, Walter A Kukull47, Lindsay A Farrer48, Lisa L Barnes49,50,51, Thomas G Beach52, F Yesim Demirci39, Elizabeth Head53, Christine M Hulette54, Gregory A Jicha55, John S K Kauwe56, Jeffrey A Kaye57, James B Leverenz58, Allan I Levey59, Andrew P Lieberman60, Vernon S Pankratz61, Wayne W Poon62, Joseph F Quinn63,64, Andrew J Saykin65, Lon S Schneider66, Amanda G Smith67, Joshua A Sonnen68,69, Robert A Stern70, Vivianna M Van Deerlin71, Linda J Van Eldik53, Denise Harold72, Giancarlo Russo73, David C Rubinsztein74,75, Anthony Bayer76, Magda Tsolaki77,78, Petra Proitsi79, Nick C Fox80,7, Harald Hampel81,82,83,84, Michael J Owen85,86, Simon Mead87, Peter Passmore88, Kevin Morgan89, Markus M Nöthen90,91, Martin Rossor92, Michelle K Lupton93,94, Per Hoffmann90,91,95,96, Johannes Kornhuber97, Brian Lawlor98, Andrew McQuillin99, Ammar Al-Chalabi100,101, Joshua C Bis102, Agustin Ruiz103,104, Mercè Boada103, Sudha Seshadri105,106,107, Alexa Beiser108,109,107, Kenneth Rice110, Sven J van der Lee111, Philip L De Jager112, Daniel H Geschwind113,114,115, Matthias Riemenschneider116, Steffi Riedel-Heller117, Jerome I Rotter118, Gerhard Ransmayr119, Bradley T Hyman13,14, Carlos Cruchaga120, Montserrat Alegret103, Bendik Winsvold121,122, Priit Palta123,124, Kai-How Farh125,3, Ester Cuenca-Leon12,3,2, Nicholas Furlotte126, Tobias Kurth127, Lannie Ligthart128, Gisela M Terwindt129, Tobias Freilinger130,131, Caroline Ran132, Scott D Gordon93, Guntram Borck133, Hieab H H Adams111,134, Terho Lehtimäki135, Juho Wedenoja136,137, Julie E Buring138, Markus Schürks139, Maria Hrafnsdottir140, Jouke-Jan Hottenga128,141, Brenda Penninx142, Ville Artto143, Mari Kaunisto123, Salli Vepsäläinen143, Nicholas G Martin93, Grant W Montgomery93,144, Mitja I Kurki4,3,12,123, Eija Hämäläinen123, Hailiang Huang4,2,145, Jie Huang146,147, Cynthia Sandor148, Caleb Webber148,11, Bertram Muller-Myhsok149,150,151, Stefan Schreiber152,153, Veikko Salomaa154, Elizabeth Loehrer155, Hartmut Göbel156, Alfons Macaya157, Patricia Pozo-Rosich158,159, Thomas Hansen160,161, Thomas Werge161,162,163, Jaakko Kaprio123,137, Andres Metspalu124, Christian Kubisch164, Michel D Ferrari129, Andrea C Belin132, Arn M J M van den Maagdenberg165,129, John-Anker Zwart166, Dorret Boomsma167,128, Nicholas Eriksson126, Jes Olesen160, Daniel I Chasman168,14, Dale R Nyholt169, Andreja Avbersek170, Larry Baum171, Samuel Berkovic172, Jonathan Bradfield173, Russell J Buono174,175,176, Claudia B Catarino170,177, Patrick Cossette178, Peter De Jonghe179,180,181, Chantal Depondt182, Dennis Dlugos183,184, Thomas N Ferraro185,186, Jacqueline French187, Helle Hjalgrim188, Jennifer Jamnadas-Khoda170,189, Reetta Kälviäinen190,191, Wolfram S Kunz192,193, Holger Lerche131, Costin Leu194, Dick Lindhout195,196, Warren Lo197,198, Daniel Lowenstein199, Mark McCormack200,201, Rikke S Møller202,203, Anne Molloy204, Ping-Wing Ng205,206, Karen Oliver207, Michael Privitera208,209, Rodney Radtke210, Ann-Kathrin Ruppert211, Thomas Sander211, Steven Schachter212,13,14, Christoph Schankin213,214, Ingrid Scheffer215,216,217, Susanne Schoch218, Sanjay M Sisodiya219,220, Philip Smith221, Michael Sperling222, Pasquale Striano223, Rainer Surges224,225, G Neil Thomas226, Frank Visscher227, Christopher D Whelan200, Federico Zara228, Erin L Heinzen229, Anthony Marson230,231, Felicitas Becker232,233, Hans Stroink234, Fritz Zimprich235, Thomas Gasser236,237, Raphael Gibbs238, Peter Heutink237,236, Maria Martinez239,240, Huw R Morris219, Manu Sharma241, Mina Ryten219, Kin Y Mok8,242, Sara Pulit243,244,3, Steve Bevan245, Elizabeth Holliday246, John Attia247,248, Thomas Battey12,249, Giorgio Boncoraglio250,251, Vincent Thijs217,252, Wei-Min Chen253, Braxton Mitchell254,255, Peter Rothwell256, Pankaj Sharma257,258, Cathie Sudlow259, Astrid Vicente260,261, Hugh Markus262, Christina Kourkoulis3,263,12, Joana Pera264, Miriam Raffeld3,12,263,265, Scott Silliman266, Vesna Boraska Perica267, Laura M Thornton268, Laura M Huckins269, N William Rayner270,271,272, Cathryn M Lewis273, Monica Gratacos274, Filip Rybakowski275, Anna Keski-Rahkonen276, Anu Raevuori277,276, James I Hudson278, Ted Reichborn-Kjennerud279,280, Palmiero Monteleone281, Andreas Karwautz282, Katrin Mannik124,283, Jessica H Baker268, Julie K O'Toole284, Sara E Trace285, Oliver S P Davis286, Sietske G Helder287,273, Stefan Ehrlich288, Beate Herpertz-Dahlmann289, Unna N Danner290,291, Annemarie A van Elburg290,291, Maurizio Clementi292, Monica Forzan293, Elisa Docampo294,295, Jolanta Lissowska296, Joanna Hauser297, Alfonso Tortorella298, Mario Maj299, Fragiskos Gonidakis300, Konstantinos Tziouvas301, Hana Papezova302,303, Zeynep Yilmaz268, Gudrun Wagner304, Sarah Cohen-Woods305, Stefan Herms90,91,95,96, Antonio Julià306, Raquel Rabionet307,308,309,310, Danielle M Dick311, Samuli Ripatti123,137,312, Ole A Andreassen313,314, Thomas Espeseth313,315,316, Astri J Lundervold317,316, Vidar M Steen318,319, Dalila Pinto320,321,322,323, Stephen W Scherer324,325, Harald Aschauer326, Alexandra Schosser327,328, Lars Alfredsson329, Leonid Padyukov330, Katherine A Halmi331, James Mitchell332,333, Michael Strober334, Andrew W Bergen335,336, Walter Kaye337, Jin Peng Szatkiewicz268, Bru Cormand307,308,309,338, Josep Antoni Ramos-Quiroga339,340,341,342, Cristina Sánchez-Mora340,339,341, Marta Ribasés340,339,341, Miguel Casas343,344,339,345, Amaia Hervas346, Maria Jesús Arranz347, Jan Haavik348,349, Tetyana Zayats348,4, Stefan Johansson350,319, Nigel Williams10, Astrid Dempfle351, Aribert Rothenberger352, Jonna Kuntsi353, Robert D Oades354, Tobias Banaschewski355, Barbara Franke356,357,358, Jan K Buitelaar359,360, Alejandro Arias Vasquez361, Alysa E Doyle263,14, Andreas Reif362, Klaus-Peter Lesch363,364,365, Christine Freitag366, Olga Rivero365, Haukur Palmason140, Marcel Romanos367, Kate Langley368,85, Marcella Rietschel369, Stephanie H Witt369, Soeren Dalsgaard370,163,371, Anders D Børglum372,163,373,374, Irwin Waldman375, Beth Wilmot376, Nikolas Molly377, Claiton H D Bau378,379, Jennifer Crosbie380,381, Russell Schachar382,381, Sandra K Loo383, James J McGough384, Eugenio H Grevet379,385, Sarah E Medland93, Elise Robinson4,2,6, Lauren A Weiss386,387,388, Elena Bacchelli389, Anthony Bailey390,391, Vanessa Bal386,387,388, Agatino Battaglia392, Catalina Betancur393, Patrick Bolton353,394, Rita Cantor395, Patrícia Celestino-Soper396, Geraldine Dawson397, Silvia De Rubeis320,321,398, Frederico Duque399,400, Andrew Green401,402, Sabine M Klauck403, Marion Leboyer404,405,406, Pat Levitt407,66, Elena Maestrini389, Shrikant Mane408,409, Daniel Moreno- De-Luca410, Jeremy Parr411,412,413, Regina Regan402,414, Abraham Reichenberg269, Sven Sandin320,321,415, Jacob Vorstman416,417, Thomas Wassink418, Ellen Wijsman419,110, Edwin Cook420, Susan Santangelo421,422, Richard Delorme423,424, Bernadette Rogé425,426,427, Tiago Magalhaes414,428, Dan Arking429, Thomas G Schulze430,431,369,432,433, Robert C Thompson434,435, Jana Strohmaier369,436, Keith Matthews437,438, Ingrid Melle439,440, Derek Morris441, Douglas Blackwood442, Andrew McIntosh442, Sarah E Bergen415, Martin Schalling443,444, Stéphane Jamain404,405,406, Anna Maaser91,90, Sascha B Fischer95,445, Céline S Reinbold95,445, Janice M Fullerton446,447, José Guzman-Parra448,449, Fermin Mayoral448,449, Peter R Schofield446,447, Sven Cichon95,445,450, Thomas W Mühleisen450,445, Franziska Degenhardt451, Johannes Schumacher451, Michael Bauer452, Philip B Mitchell453,454, Elliot S Gershon455, John Rice456, James B Potash432, Peter P Zandi457, Nick Craddock85, I Nicol Ferrier411, Martin Alda458,459, Guy A Rouleau460,461, Gustavo Turecki462, Roel Ophoff463,464, Carlos Pato465, Adebayo Anjorin466, Eli Stahl269,312, Markus Leber467, Piotr M Czerski468, Cristiana Cruceanu469,470, Ian R Jones471, Danielle Posthuma472,473, Till F M Andlauer149,474, Andreas J Forstner91,90,96,95,475, Fabian Streit369, Bernhard T Baune476, Tracy Air476, Grant Sinnamon477,478, Naomi R Wray144,479, Donald J MacIntyre480, David Porteous481, Georg Homuth482, Margarita Rivera483,273, Jakob Grove163,373,372,484, Christel M Middeldorp485,486,128, Ian Hickie487, Michele Pergadia120, Divya Mehta488,489, Johannes H Smit142,490,491, Rick Jansen142, Eco de Geus128,490, Erin Dunn12,492, Qingqin S Li493, Matthias Nauck494,495, Robert A Schoevers496, Aartjan Tf Beekman142,497, James A Knowles498, Alexander Viktorin415, Paul Arnold499,500,417, Cathy L Barr501,382,381, Gabriel Bedoya-Berrio502, O Joseph Bienvenu503, Helena Brentani504, Christie Burton382, Beatriz Camarena505, Carolina Cappi504, Danielle Cath506,507, Maria Cavallini508, Daniele Cusi509, Sabrina Darrow510, Damiaan Denys511,512, Eske M Derks93, Andrea Dietrich513,514, Thomas Fernandez515, Martijn Figee511,320, Nelson Freimer463, Gloria Gerber12, Marco Grados432, Erica Greenberg263, Gregory L Hanna435, Andreas Hartmann516,517,518, Matthew E Hirschtritt386,388, Pieter J Hoekstra514, Alden Huang519,384, Chaim Huyser520,521, Cornelia Illmann263, Michael Jenike14, Samuel Kuperman522, Bennett Leventhal510, Christine Lochner523, Gholson J Lyon524, Fabio Macciardi525, Marcos Madruga-Garrido526, Irene A Malaty527, Athanasios Maras528, Lauren McGrath529, Eurípedes C Miguel530, Pablo Mir531,532, Gerald Nestadt432, Humberto Nicolini533,534, Michael S Okun535,536,537, Andrew Pakstis409, Peristera Paschou538, John Piacentini384, Christopher Pittenger539, Kerstin Plessen540,541, Vasily Ramensky542, Eliana M Ramos543, Victor Reus386,388, Margaret A Richter544,545, Mark A Riddle503, Mary M Robertson546, Veit Roessner547, Maria Rosário548,549, Jack F Samuels432, Paul Sandor545,550,551, Dan J Stein552,523, Fotis Tsetsos553, Filip Van Nieuwerburgh554, Sarah Weatherall12, Jens R Wendland555, Tomasz Wolanczyk556, Yulia Worbe557,558,559, Gwyneth Zai545, Fernando S Goes432, Nicole McLaughlin560,561, Paul S Nestadt432, Hans-Jorgen Grabe562, Christel Depienne563,564,565, Anuar Konkashbaev566, Nuria Lanzagorta534, Ana Valencia-Duarte567,568, Elvira Bramon99, Nancy Buccola569, Wiepke Cahn570, Murray Cairns571,572,573, Siow A Chong574, David Cohen575,576, Benedicto Crespo-Facorro577,341, James Crowley285, Michael Davidson578,579, Lynn DeLisi580,14, Timothy Dinan581,582, Gary Donohoe583, Elodie Drapeau269,320,321, Jubao Duan584,585, Lieuwe Haan511,586, David Hougaard587, Sena Karachanak-Yankova588, Andrey Khrunin589, Janis Klovins590, Vaidutis Kučinskas591, Jimmy Lee Chee Keong592, Svetlana Limborska593, Carmel Loughland594,247, Jouko Lönnqvist154,595, Brion Maher457, Manuel Mattheisen596,597,598, Colm McDonald599,600, Kieran C Murphy601, Igor Nenadic602,603, Jim van Os570,604,605, Christos Pantelis606,607,217, Michele Pato465, Tracey Petryshen2,12, Digby Quested608,609, Panos Roussos269, Alan R Sanders610,585, Ulrich Schall247, Sibylle G Schwab611, Kang Sim612,613,574, Hon-Cheong So614,615,616, Elisabeth Stögmann235, Mythily Subramaniam574,613, Draga Toncheva588, John Waddington200, James Walters85,86, Mark Weiser579,617, Wei Cheng268, Robert Cloninger618, David Curtis619,620, Pablo V Gejman585,610, Frans Henskens621,622,248, Morten Mattingsdal439,623, Sang-Yun Oh624,625, Rodney Scott247,248,626, Bradley Webb627, Gerome Breen628,629, Claire Churchhouse4,2,3, Cynthia M Bulik630,415, Mark Daly4,2,3, Martin Dichgans15,150, Stephen V Faraone631, Rita Guerreiro7,8, Peter Holmans10, Kenneth S Kendler632, Bobby Koeleman633, Carol A Mathews634,537, Alkes Price3,6, Jeremiah Scharf2,3,12,12,635,13,14, Pamela Sklar269, Julie Williams10,11, Nicholas W Wood8,619, Chris Cotsapas3,636, Aarno Palotie4,2,3,12,13,14,123, Jordan W Smoller2,12, Patrick Sullivan630,637, Jonathan Rosand3,12,13,14, Aiden Corvin638,639, Benjamin M Neale1,2,3, Jonathan M Schott80, Richard Anney85,86, Josephine Elia640,641, Maria Grigoroiu-Serbanescu642, Howard J Edenberg643, Robin Murray353.
Abstract
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.Entities:
Mesh：
Year: 2018 PMID： 29930110 PMCID： PMC6097237 DOI： 10.1126/science.aap8757
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728