Literature DB >> 31451505

CreC Sensor Kinase Activation Enhances Growth of Escherichia coli in the Presence of Cephalosporins and Carbapenems.

Yuiko Takebayashi1, Emma S Taylor1, Sam Whitwam1, Matthew B Avison2.   

Abstract

Mutants with enhanced growth in the presence of an antibiotic are more difficult to identify than mutants where the antibiotic's MIC increases, because they are not amenable to lethal selection in vitro We report that activatory mutations in the CreC signal sensor enhance growth of Escherichia coli in the presence of cefoxitin, cefotaxime, and meropenem, without increasing their MICs. Enhanced growth is dependent on overproduction of the inner membrane cre regulon protein CreD.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  fitness; tolerance; two-component system

Mesh：

Substances：

Year:  2019        PMID： 31451505      PMCID： PMC6811401          DOI： 10.1128/AAC.00846-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

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Authors:  J W Mouton; D F J Brown; P Apfalter; R Cantón; C G Giske; M Ivanova; A P MacGowan; A Rodloff; C-J Soussy; M Steinbakk; G Kahlmeter
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Authors:  Virve I Enne; Peter M Bennett; David M Livermore; Lucinda M C Hall
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7.  Role of the 'cre/blr-tag' DNA sequence in regulation of gene expression by the Aeromonas hydrophila beta-lactamase regulator, BlrA.

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Journal:  J Antimicrob Chemother       Date:  2004-01-16       Impact factor: 5.790

8.  Genetic linkage of the penicillinase gene, amp, and blrAB, encoding the regulator of beta-lactamase expression in Aeromonas spp.

Authors:  Pannika Niumsup; Alan M Simm; Kurshid Nurmahomed; Timothy R Walsh; Peter M Bennett; Matthew B Avison
Journal:  J Antimicrob Chemother       Date:  2003-05-13       Impact factor: 5.790

9.  Defining the growth conditions and promoter-proximal DNA sequences required for activation of gene expression by CreBC in Escherichia coli.

Authors:  S James L Cariss; Amy E Tayler; Matthew B Avison
Journal:  J Bacteriol       Date:  2008-03-28       Impact factor: 3.490

10.  Beta-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein.

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