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Literature DB >> 3144456

A VH gene is located within 95 Kb of the human immunoglobulin heavy chain constant region genes.

Abstract

Using cosmids covering about 117 Kb upstream of the human immunoglobulin chain C mu gene, we have identified a potentially functional VH gene, belonging to the VHVI subgroup. This VHVI gene is only about 95 Kb from the C mu gene and is probably the first functional VH segment of the Igh locus. These results illustrate the proximity of the human VH, DH and JH segments involved in creation of the complete heavy chain genes.

Entities: Disease Gene Species

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Year: 1988 PMID： 3144456 DOI： 10.1002/eji.1830181130

Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532

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Cited

12 in total

1. Direct detection of insertion/deletion polymorphisms in an autosomal region by analyzing high-density markers in individual spermatozoa.

Authors: Sreemanta Pramanik; Honghua Li
Journal: Am J Hum Genet Date: 2002-11-19 Impact factor: 11.025

2. Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life.

Authors: H W Schroeder; J Y Wang
Journal: Proc Natl Acad Sci U S A Date: 1990-08 Impact factor: 11.205

3. A deletion map of the human immunoglobulin heavy chain variable region.

Authors: M A Walter; H M Dosch; D W Cox
Journal: J Exp Med Date: 1991-08-01 Impact factor: 14.307

4. Molecular characterization of five human anti-human immunodeficiency virus type 1 antibody heavy chains reveals extensive somatic mutation typical of an antigen-driven immune response.

Authors: J S Andris; S Johnson; S Zolla-Pazner; J D Capra
Journal: Proc Natl Acad Sci U S A Date: 1991-09-01 Impact factor: 11.205

5. Determination of gene organization in individual haplotypes by analyzing single DNA fragments from single spermatozoa.

Authors: X Cui; H Li
Journal: Proc Natl Acad Sci U S A Date: 1998-09-01 Impact factor: 11.205

A VH gene is located within 95 Kb of the human immunoglobulin heavy chain constant region genes.

1. Direct detection of insertion/deletion polymorphisms in an autosomal region by analyzing high-density markers in individual spermatozoa.

2. Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life.

3. A deletion map of the human immunoglobulin heavy chain variable region.

4. Molecular characterization of five human anti-human immunodeficiency virus type 1 antibody heavy chains reveals extensive somatic mutation typical of an antigen-driven immune response.

5. Determination of gene organization in individual haplotypes by analyzing single DNA fragments from single spermatozoa.

6. Superantigen properties of a human sialoprotein involved in gut-associated immunity.

7. HAPPY mapping of a YAC reveals alternative haplotypes in the human immunoglobulin VH locus.

8. A fetally expressed immunoglobulin VH1 gene belongs to a complex set of alleles.

9. The physical organization of the human immunoglobulin heavy chain gene complex.

10. Nonuniform linkage disequilibrium within a 1,500-kb region of the human immunoglobulin heavy-chain complex.