Literature DB >> 314366

The immunological effects of thymectomy in myasthenia gravis.

G K Scadding, H C Thomas, C W Havard.   

Abstract

Thymus-derived (T) lymphocytes in the peripheral blood and cellular immune function have been studied in ten patients with myasthenia gravis and in fifteen different myasthenic patients more than 10 years after thymectomy. The results were compared with those of a normal control population. The non-thymectomized myasthenic patients had normal T lymphocyte concentrations measured by rosetting with native sheep red cells. These patients also showed normal sensitization and recall of delayed hypersensitivity, phytohaemagglutinin (PHA) induced lymphocyte transformation and antibody-assisted (K cell) cytotoxicity; however, PHA-induced cytotoxicity was markedly reduced (P less than 0.001). The thymectomized group exhibited a lower mean percentage and absolute number of E-rosette-forming cells, which returned toward normal after in vitro treatment with thymosin. PHA-induced lymphocyte cytotoxicity, however, was normal in the patients who had undergone thymectomy, as were lymphocyte transformation, antibody-assisted cytotoxicity and sensitization to dinitrochlorobenzene (DNCB); there was a decrease in recall of established delayed hypersensitivity. Adult thymectomy in man, therefore, produces a partial and dissociated decrease in T cell responses and it is unlikely that the beneficial effect of this operation in myasthenia gravis is related to immunosuppression.

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Year:  1979        PMID: 314366      PMCID: PMC1537729     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN: 0009-9104            Impact factor:   4.330


  65 in total

Review 1.  THE THYMUS AND THE DEVELOPMENT OF IMMUNOLOGIC RESPONSIVENESS.

Authors:  J F MILLER
Journal:  Science       Date:  1964-06-26       Impact factor: 47.728

2.  AN EFFECT OF THYMECTOMY ON RECOVERY FROM IMMUNOLOGICAL PARALYSIS.

Authors:  R B TAYLOR
Journal:  Immunology       Date:  1964-09       Impact factor: 7.397

3.  EVIDENCE FOR A HUMORAL THYMUS FACTOR RESPONSIBLE FOR THE MATURATION OF IMMUNOLOGICAL FACULTY.

Authors:  D OSOBA; J F MILLER
Journal:  Nature       Date:  1963-08-17       Impact factor: 49.962

4.  PRIMARY AND SECONDARY ANTITOXIN RESPONSES IN THYMECTOMIZED MICE.

Authors:  M W HESS; H COTTIER; R D STONER
Journal:  J Immunol       Date:  1963-09       Impact factor: 5.422

5.  STUDIES IN MYASTHENIA GRAVIS. IMMUNOLOGIC RESPONSE IN THYMECTOMIZED AND NONTHYMECTOMIZED PATIENTS.

Authors:  P KORNFELD; S SIEGAL; L B WEINER; K E OSSERMAN
Journal:  Ann Intern Med       Date:  1965-09       Impact factor: 25.391

6.  MYASTHENIA GRAVIS AND TUMORS OF THE THYMIC REGION: REPORT OF A CASE IN WHICH THE TUMOR WAS REMOVED.

Authors:  A Blalock; M F Mason; H J Morgan; S S Riven
Journal:  Ann Surg       Date:  1939-10       Impact factor: 12.969

7.  Immunological function of the thymus.

Authors:  J F MILLER
Journal:  Lancet       Date:  1961-09-30       Impact factor: 79.321

8.  Etiology and pathogenesis of mouse leukemia.

Authors:  J F MILLER
Journal:  Adv Cancer Res       Date:  1961       Impact factor: 6.242

9.  Skin homograft survival in thymectomized mice.

Authors:  C MARTINEZ; J KERSEY; B W PAPERMASTER; R A GOOD
Journal:  Proc Soc Exp Biol Med       Date:  1962-01

10.  THYMECTOMY: PROLONGATION OF IMMUNOLOGICAL TOLERANCE IN THE ADULT MOUSE.

Authors:  H N CLAMAN; D W TALMAGE
Journal:  Science       Date:  1963-09-20       Impact factor: 47.728

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  6 in total

Review 1.  Phenotypic and functional analysis of lymphocytes in myasthenia gravis.

Authors:  A I Levinson; R P Lisak; B Zweiman; M Kornstein
Journal:  Springer Semin Immunopathol       Date:  1985

Review 2.  Pathogenesis and treatment of myasthenia gravis.

Authors:  G K Scadding; C W Havard
Journal:  Br Med J (Clin Res Ed)       Date:  1981-10-17

3.  Lymphocyte populations in patients with myasthenia gravis. Influence of thymectomy and immunosuppressive drugs.

Authors:  G Ippoliti; G Piccolo; M Lombardi; G Carnevale Maffé; V Cosi; P Pinelli
Journal:  Ital J Neurol Sci       Date:  1982-12

4.  Lymphocyte subpopulations and surface membrane immunoglobulins in myasthenia gravis.

Authors:  G Landi; M Galli; G Ciboddo; G Colombo; G Scarlato
Journal:  J Neurol Neurosurg Psychiatry       Date:  1982-02       Impact factor: 10.154

5.  Changes in human T lymphocytes after thymectomy and during senescence.

Authors:  R J Van de Griend; M Carreno; R Van Doorn; C J Leupers; A Van den Ende; P Wijermans; H J Oosterhuis; A Astaldi
Journal:  J Clin Immunol       Date:  1982-10       Impact factor: 8.317

6.  Immunoregulation and anti-nuclear antibodies in mercury-induced glomerulopathy in the rat.

Authors:  J J Weening; P J Hoedemaeker; W W Bakker
Journal:  Clin Exp Immunol       Date:  1981-07       Impact factor: 4.330

  6 in total

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