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Literature DB >> 14043367

THYMECTOMY: PROLONGATION OF IMMUNOLOGICAL TOLERANCE IN THE ADULT MOUSE.

Abstract

The loss of acquired immunological tolerance of mice to bovine gamma globulin depended on the presence of the thymus. Mice were repeatedly injected with bovine gamma-globulin from birth until the age of 5 to 10 weeks and then thymectomized or sham operated. After 130 to 160 days without antigen, an accelerated (immune) disappearance of I(125) bovine gamma-globulin could be uniformly induced in controls while thymectomized mice remained tolerant. Adult thymectomized mice made tolerant by a single injection of bovine gamma-globulin lost tolerance more slowly than sham-operated controls.

Entities: Species

Keywords: ANTIGEN-ANTIBODY REACTIONS; EXPERIMENTAL LAB STUDY; GAMMA GLOBULIN; IMMUNITY; MICE; SURGERY, OPERATIVE; THYMUS GLAND

Mesh：

Substances：
gamma-Globulins

Year: 1963 PMID： 14043367 DOI： 10.1126/science.141.3586.1193

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

25 in total

Review 4. Suppression of the immune response.

Authors: J Bradley; C J Elson
Journal: J Med Genet Date: 1971-09 Impact factor: 6.318

Review 5. The gamma system, pathology and therapeutics.

Authors: R H De Lellis
Journal: Postgrad Med J Date: 1969-02 Impact factor: 2.401

6. The immunological effects of thymectomy in myasthenia gravis.

Authors: G K Scadding; H C Thomas; C W Havard
Journal: Clin Exp Immunol Date: 1979-05 Impact factor: 4.330

7. Influence of molecular structure of the tolerogenicity of bacterial dextrans. III. Dissociation between tolerance and immunity to the alpha1--6- and alpha1--3-linked epitopes of dextran B1355.

Authors: J G Howard; B M Courtenay; G Vicari
Journal: Immunology Date: 1975-10 Impact factor: 7.397

THYMECTOMY: PROLONGATION OF IMMUNOLOGICAL TOLERANCE IN THE ADULT MOUSE.

1. AN EFFECT OF THYMECTOMY ON RECOVERY FROM IMMUNOLOGICAL PARALYSIS.

2. Serendipity in the discovery of T cell/B cell cooperation.

3. Changes in the thymus, spleen and lymph nodes during pregnancy and lactation in the rat.

Review 4. Suppression of the immune response.

Review 5. The gamma system, pathology and therapeutics.

6. The immunological effects of thymectomy in myasthenia gravis.

7. Influence of molecular structure of the tolerogenicity of bacterial dextrans. III. Dissociation between tolerance and immunity to the alpha1--6- and alpha1--3-linked epitopes of dextran B1355.

8. Responses to immunization in the thymus of the adult mouse.

9. Rapid breaking of tolerance against Escherichia coli lipopolysaccharide in vivo and in vitro.

10. Induction and reversal of immune paralysis in vitro.