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Literature DB >> 31435696

Membrane Dynamics in Health and Disease: Impact on Cellular Signalling.

Abstract

Biological membranes display a staggering complexity of lipids and proteins orchestrating cellular functions. Superior analytical tools coupled with numerous functional cellular screens have enabled us to query their role in cellular signalling, trafficking, guiding protein structure and function-all of which rely on the dynamic membrane lipid properties indispensable for proper cellular functions. Alteration of these has led to emergence of various pathological conditions, thus opening an area of lipid-centric therapeutic approaches. This perspective is a short summary of the dynamic properties of membranes essential for proper cellular functions, dictating both protein and lipid functions, and mis-regulated in diseases. Towards the end, we focus on some challenges lying ahead and potential means to tackle the same, mainly underscored by multi-disciplinary approaches.

Entities: Chemical Gene

Keywords: Lipid diffusion; Lipid domains; Lipid-protein interactions; Membrane lipid structure; Membrane-targeting drugs

Mesh：

Substances：

Year: 2019 PMID： 31435696 DOI： 10.1007/s00232-019-00087-0

Source DB: PubMed Journal: J Membr Biol ISSN： 0022-2631 Impact factor: 1.843

122 in total

1. Biological and immunological properties of human immunodeficiency virus type 1 envelope glycoprotein: analysis of proteins with truncations and deletions expressed by recombinant vaccinia viruses.

Authors: P L Earl; S Koenig; B Moss
Journal: J Virol Date: 1991-01 Impact factor: 5.103

2. Identification and Validation of Candidate Gene Module Along With Immune Cells Infiltration Patterns in Atherosclerosis Progression to Plaque Rupture via Transcriptome Analysis.

Authors: Jing Xu; Cheng Chen; Yuejin Yang
Journal: Front Cardiovasc Med Date: 2022-06-22

2 in total

Membrane Dynamics in Health and Disease: Impact on Cellular Signalling.

1. Biological and immunological properties of human immunodeficiency virus type 1 envelope glycoprotein: analysis of proteins with truncations and deletions expressed by recombinant vaccinia viruses.

Review 2. Mechanisms of membrane curvature sensing.

Review 3. Deciphering lipid codes: K-Ras as a paradigm.

4. Group A Streptococcus tissue invasion by CD44-mediated cell signalling.

Review 5. Polyphosphoinositide binding domains: Key to inositol lipid biology.

6. Sphingolipids, cholesterol, and HIV-1: a paradigm in viral fusion.

7. Cholesterol modulates glycolipid conformation and receptor activity.

8. Lipidomic analysis of phospholipids from human mammary epithelial and breast cancer cell lines.

9. Visualizing lipid structure and raft domains in living cells with two-photon microscopy.

10. Scanning STED-FCS reveals spatiotemporal heterogeneity of lipid interaction in the plasma membrane of living cells.

1. Special Issue: Membrane and Receptor Dynamics.

2. Identification and Validation of Candidate Gene Module Along With Immune Cells Infiltration Patterns in Atherosclerosis Progression to Plaque Rupture via Transcriptome Analysis.