| Literature DB >> 31435688 |
Abstract
The tRNA nucleotidyltransferases and poly(A) polymerases belong to a superfamily of nucleotidyltransferases. The amino acid sequences of a number of bacterial tRNA nucleotidyltransferases and poly(A) polymerases have been used to construct a rooted, neighbor-joining phylogenetic tree. Using information gleaned from that analysis, along with data from the rRNA-based phylogenetic tree, structural data available on a number of members of the superfamily and other biochemical information on the superfamily, it is possible to suggest a scheme for the evolution of the bacterial tRNA nucleotidyltransferases and poly(A) polymerases from ancestral species. Elements of that scheme are discussed along with questions arising from the scheme which can be explored experimentally.Keywords: Alien index; CCA end; Horizontal gene transfer; Nucleotidyltransferase; Phylogeny; Poly(A) polymerase; Polynucleotide phosphorylase; tRNA
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Year: 2019 PMID: 31435688 DOI: 10.1007/s00239-019-09907-2
Source DB: PubMed Journal: J Mol Evol ISSN: 0022-2844 Impact factor: 2.395