| Literature DB >> 31432762 |
Zhao Zhang1, Hang Ruan1, Chun-Jie Liu2, Youqiong Ye1, Jing Gong1, Lixia Diao3, An-Yuan Guo2, Leng Han1,4.
Abstract
Transfer RNAs (tRNAs) play critical roles in human cancer. Currently, no database provides the expression landscape and clinical relevance of tRNAs across a variety of human cancers. Utilizing miRNA-seq data from The Cancer Genome Atlas, we quantified the relative expression of tRNA genes and merged them into the codon level and amino level across 31 cancer types. The expression of tRNAs is associated with clinical features of patient smoking history and overall survival, and disease stage, subtype, and grade. We further analysed codon frequency and amino acid frequency for each protein coding gene and linked alterations of tRNA expression with protein translational efficiency. We include these data resources in a user-friendly data portal, tRic (tRNA in cancer, https://hanlab.uth.edu/tRic/ or http://bioinfo.life.hust.edu.cn/tRic/), which can be of significant interest to the research community.Entities:
Keywords: amino acid; cancer; codon; codon usage; tRNA
Year: 2019 PMID： 31432762 PMCID： PMC7567503 DOI： 10.1080/15476286.2019.1657744
Source DB: PubMed Journal: RNA Biol ISSN： 1547-6286 Impact factor: 4.652