Literature DB >> 23550210

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal.

Jianjiong Gao1, Bülent Arman Aksoy, Ugur Dogrusoz, Gideon Dresdner, Benjamin Gross, S Onur Sumer, Yichao Sun, Anders Jacobsen, Rileen Sinha, Erik Larsson, Ethan Cerami, Chris Sander, Nikolaus Schultz.   

Abstract

The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal reduces molecular profiling data from cancer tissues and cell lines into readily understandable genetic, epigenetic, gene expression, and proteomic events. The query interface combined with customized data storage enables researchers to interactively explore genetic alterations across samples, genes, and pathways and, when available in the underlying data, to link these to clinical outcomes. The portal provides graphical summaries of gene-level data from multiple platforms, network visualization and analysis, survival analysis, patient-centric queries, and software programmatic access. The intuitive Web interface of the portal makes complex cancer genomics profiles accessible to researchers and clinicians without requiring bioinformatics expertise, thus facilitating biological discoveries. Here, we provide a practical guide to the analysis and visualization features of the cBioPortal for Cancer Genomics.

Entities:  

Mesh：

Year:  2013        PMID： 23550210      PMCID： PMC4160307          DOI： 10.1126/scisignal.2004088

Source DB:  PubMed          Journal:  Sci Signal        ISSN： 1945-0877            Impact factor:   8.192


  34 in total

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5.  The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data.

Authors:  Ethan Cerami; Jianjiong Gao; Ugur Dogrusoz; Benjamin E Gross; Selcuk Onur Sumer; Bülent Arman Aksoy; Anders Jacobsen; Caitlin J Byrne; Michael L Heuer; Erik Larsson; Yevgeniy Antipin; Boris Reva; Arthur P Goldberg; Chris Sander; Nikolaus Schultz
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9.  Comprehensive molecular portraits of human breast tumours.

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Journal:  Nature       Date:  2012-09-09       Impact factor: 49.962
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  2000 in total

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Journal:  Genet Epidemiol       Date:  2018-12-04       Impact factor: 2.135

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4.  Transcriptional regulation of O-GlcNAc homeostasis is disrupted in pancreatic cancer.

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5.  Ras Suppresses TXNIP Expression by Restricting Ribosome Translocation.

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7.  Nicotinamide metabolism regulates glioblastoma stem cell maintenance.

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8.  Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance.

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Review 9.  Collection, integration and analysis of cancer genomic profiles: from data to insight.

Authors:  Jianjiong Gao; Giovanni Ciriello; Chris Sander; Nikolaus Schultz
Journal:  Curr Opin Genet Dev       Date:  2014-02-27       Impact factor: 5.578

10.  Dynamic Change of Transcription Pausing through Modulating NELF Protein Stability Regulates Granulocytic Differentiation.

Authors:  Xiuli Liu; Aishwarya A Gogate; Melodi Tastemel; Venkat S Malladi; Huiyu Yao; Kim Nguyen; Lily Jun-Shen Huang; Xiaoying Bai
Journal:  Blood Adv       Date:  2017-08-08
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