Literature DB >> 31430413

Therapeutic effects of Crocin in autoimmune diseases: A review.

Shahla Korani1, Mitra Korani2, Thozhukat Sathyapalan3, Amirhossein Sahebkar4,5,6.   

Abstract

The immune system when acts against selfmolecules results in an imbalance in immunologic tolerance leading to the development of several autoimmune diseases (ADs) such as rheumatoid arthritis, asthma, ulcerative colitis, type 1 diabetes, and multiple sclerosis. Improved recognition of the mechanisms of ADs has led to the advancement of the management of these diseases. The principal mediators of ADs are inflammatory molecules. The herbal medicines due to their antioxidant and antiinflammatory properties have an important role in the management of ADs. Crocin is the principal chemical component extracted from saffron, which is a medicinal plant. This review focuses on the therapeutic effects of Crocin in various ADs.
© 2019 International Union of Biochemistry and Molecular Biology.

Entities:  

Keywords:  Crocin; anti-oxidant; autoimmune diseases; inflammation; saffron

Mesh：

Substances：

Year:  2019        PMID： 31430413     DOI： 10.1002/biof.1557

Source DB:  PubMed          Journal:  Biofactors        ISSN： 0951-6433            Impact factor:   6.113


  14 in total

1.  Crocin Improves Diabetes-Induced Oxidative Stress via Downregulating the Nox-4 in Myocardium of Diabetic Rats.

Authors:  Habib Yaribeygi; Mina Maleki; Mohammad Taghi Mohammadi; Thozhukat Sathyapalan; Tannaz Jamialahmadi; Amirhossein Sahebkar
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

2.  Evaluation of the Effect of Crocin on Doxorubicin-Induced Cardiotoxicity.

Authors:  Parisa Esmaili Motlagh; Arefeh Ghafari Novin; Fatemeh Ghahari; Amin Nikzad; Mohadeseh Khoshandam; Saba Mardani; Hashem Khanbabaei; Alireza Farsinejad; Thozhukat Sathyapalan; Amirhossein Sahebkar; Hossein Pourghadamyari
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

3.  Crocin restores the balance of Th1/Th2 immune cell response in ConA-treated human lymphocytes.

Authors:  Hakimeh Abdi; Zahra Aganj; Hossein Hosseinzadeh; Fatemeh Mosaffa
Journal:  Pharmacol Rep       Date:  2022-03-16       Impact factor: 3.024

4.  Changes of Crocin and Other Crocetin Glycosides in Saffron Through Cooking Models, and Discovery of Rare Crocetin Glycosides in the Yellow Flowers of Freesia Hybrida.

Authors:  Kazutoshi Shindo; Yuka Sakemi; Saki Shimode; Chiharu Takagi; Yohei Uwagaki; Jun-Ichiro Hattan; Miu Akao; Shiori Usui; Ayako Kiyokawa; Masako Komaki; Minoru Murahama; Miho Takemura; Isamu Ishikawa; Norihiko Misawa
Journal:  Front Nutr       Date:  2022-07-14

5.  The Effect of Triptolide Combined With Crocin on Arthritis in Mice: From Side Effect Attenuation to Therapy.

Authors:  Min Yan; Yinyin Yan; Zhenqiang Zhang; Guoqiang Wang; Wenbo Shi; Mengyuan Jiang; Junwei Zhao; Xiangxiang Wu; Huahui Zeng
Journal:  Front Pharmacol       Date:  2022-06-23       Impact factor: 5.988

Review 6.  Novel Neuroprotective Potential of Crocin in Neurodegenerative Disorders: An Illustrated Mechanistic Review.

Authors:  Sareh Kermanshahi; Ghazal Ghanavati; Mobina Abbasi-Mesrabadi; Mina Gholami; Luis Ulloa; Majid Motaghinejad; Sepideh Safari
Journal:  Neurochem Res       Date:  2020-09-17       Impact factor: 3.996

Review 7.  Crocetin and related oxygen diffusion-enhancing compounds: Review of chemical synthesis, pharmacology, clinical development, and novel therapeutic applications.

Authors:  Hriday M Shah; Ashvi S Jain; Shreerang V Joshi; Prashant S Kharkar
Journal:  Drug Dev Res       Date:  2021-04-04       Impact factor: 5.004

Review 8.  Fruit ripening: dynamics and integrated analysis of carotenoids and anthocyanins.

Authors:  Leepica Kapoor; Andrew J Simkin; C George Priya Doss; Ramamoorthy Siva
Journal:  BMC Plant Biol       Date:  2022-01-11       Impact factor: 4.215

9.  A double-blind placebo-controlled randomized trial of oral saffron in the treatment of rheumatoid arthritis.

Authors:  Maryam Sahebari; Hossein Heidari; Shima Nabavi; Mandana Khodashahi; Zahra Rezaieyazdi; Maliheh Dadgarmoghaddam; Hossein Hosseinzaheh; Shaghayegh Abbasi; Kamila Hashemzadeh
Journal:  Avicenna J Phytomed       Date:  2021 Jul-Aug

10.  Crocin Alleviates Pain Hyperalgesia in AIA Rats by Inhibiting the Spinal Wnt5a/β-Catenin Signaling Pathway and Glial Activation.

Authors:  Jin-Feng Wang; Hai-Jun Xu; Zhao-Long He; Qin Yin; Wei Cheng
Journal:  Neural Plast       Date:  2020-01-11       Impact factor: 3.599
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