| Literature DB >> 3142983 |
A S Knisely1, S M Leal, D B Singer.
Abstract
Several infants and neonates who had received long-term ventilatory assistance had subnormal diaphragmatic muscle mass on gross necropsy examination. We conducted a retrospective study of our hospital infant necropsy files to determine whether prolonged ventilatory support was associated with diminution in myofiber cross-sectional area selectively affecting the diaphragm. We found that long-term ventilatory assistance may predispose diaphragmatic myofibers to disuse atrophy or to failure or normal growth. This phenomenon may contribute to difficulties in weaning infants from ventilatory support.Entities:
Mesh：
Year: 1988 PMID： 3142983 DOI： 10.1016/s0022-3476(88)80585-7
Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406