| Literature DB >> 31423796 |
Chun-Lan Xie1,2, Renzhi Chen3, Sihan Yang3, Jin-Mei Xia1, Gai-Yun Zhang1, Chao-Hong Chen1, Yandong Zhang3, Xian-Wen Yang1.
Abstract
An intriguing cage-like polyhemiketal, nesteretal A (1), was isolated from the coral-derived actinomycete Nesterenkonia halobia. Its structure was established by extensive spectroscopic and computational methods. Nesteretal A is a highly oxygenated compound featuring an unprecedented 5/5/5/5 tetracyclic scaffold. A possible biosynthetic pathway of 1 from naturally occurring diacetyl was proposed. Compound 1 showed a weak retinoid X receptor-α (RXRα) transcriptional activation effect.Entities:
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Year: 2019 PMID： 31423796 DOI： 10.1021/acs.orglett.9b02634
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005