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Literature DB >> 31421943

Mitochondria and Alzheimer's: Is PTCD1 the Smoking Gun?

Judy Pa¹, Shea J Andrews², Russell H Swerdlow³.

Abstract

Multiple features distinguish the mitochondria of Alzheimer's disease (AD) patients from those of unaffected individuals. The causes and consequences of these differences are informed by the recent finding by Fleck et al. (J. Neurosci., 2019) that pentatricopeptide repeat-containing protein 1 (PTCD1) gene variants associate with AD. This suggests a proximal or initiating role for mitochondria in AD.

Entities: Chemical Disease Gene Mutation Species

Keywords: Alzheimer’s disease; PTCD1; mitochondria

Mesh：

Substances：

Year: 2019 PMID： 31421943 PMCID： PMC7086432 DOI： 10.1016/j.tins.2019.08.003

Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837

9 in total

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Journal: Biochim Biophys Acta Date: 2013-09-23

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Journal: Cell Date: 2017-08-10 Impact factor: 41.582

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Authors: Daniel Fleck; Lilian Phu; Erik Verschueren; Trent Hinkle; Mike Reichelt; Tushar Bhangale; Benjamin Haley; Yuanyuan Wang; Robert Graham; Donald S Kirkpatrick; Morgan Sheng; Baris Bingol
Journal: J Neurosci Date: 2019-04-04 Impact factor: 6.167

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