Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Vascular Detransformation for Cancer Therapy.

Literature DB >> 31421902

Vascular Detransformation for Cancer Therapy.

Abstract

Angiogenesis is a hallmark of cancer. However, current antivascular therapies that primarily target angiogenic factors have faced difficulties and failures in treating most cancers. It is proposed that endothelial transformation acts as an alternative driver of excessive and abnormal vascularity that fuels cancer progression and immunosuppression, and also induces resistance to therapy. Thus, vascular detransformation may serve as a promising therapeutic strategy against cancer.

Entities: Chemical Disease Gene Species

Keywords: angiogenesis; antivascular therapy; cancer; endothelial transformation; endothelial–mesenchymal transition

Mesh：

Substances：
Angiogenesis Inhibitors

Year: 2019 PMID： 31421902 PMCID： PMC7252212 DOI： 10.1016/j.trecan.2019.05.007

Source DB: PubMed Journal: Trends Cancer ISSN： 2405-8025

15 in total

1. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.

Authors: Tracy T Batchelor; A Gregory Sorensen; Emmanuelle di Tomaso; Wei-Ting Zhang; Dan G Duda; Kenneth S Cohen; Kevin R Kozak; Daniel P Cahill; Poe-Jou Chen; Mingwang Zhu; Marek Ancukiewicz; Maciej M Mrugala; Scott Plotkin; Jan Drappatz; David N Louis; Percy Ivy; David T Scadden; Thomas Benner; Jay S Loeffler; Patrick Y Wen; Rakesh K Jain
Journal: Cancer Cell Date: 2007-01 Impact factor: 31.743

2. Conversion of vascular endothelial cells into multipotent stem-like cells.

Authors: Damian Medici; Eileen M Shore; Vitali Y Lounev; Frederick S Kaplan; Raghu Kalluri; Bjorn R Olsen
Journal: Nat Med Date: 2010-11-21 Impact factor: 53.440

Review 3. Endothelial to Mesenchymal Transition: Role in Physiology and in the Pathogenesis of Human Diseases.

Authors: Sonsoles Piera-Velazquez; Sergio A Jimenez
Journal: Physiol Rev Date: 2019-04-01 Impact factor: 37.312

4. Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages.

Authors: Huanhuan He; Jingying Xu; Carmen M Warren; Dan Duan; Xinmin Li; Lily Wu; M Luisa Iruela-Arispe
Journal: Blood Date: 2012-08-23 Impact factor: 22.113

5. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis.

Authors: Elisabeth M Zeisberg; Oleg Tarnavski; Michael Zeisberg; Adam L Dorfman; Julie R McMullen; Erika Gustafsson; Anil Chandraker; Xueli Yuan; William T Pu; Anita B Roberts; Eric G Neilson; Mohamed H Sayegh; Seigo Izumo; Raghu Kalluri
Journal: Nat Med Date: 2007-07-29 Impact factor: 53.440

6. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts.

Authors: Elisabeth M Zeisberg; Scott Potenta; Liang Xie; Michael Zeisberg; Raghu Kalluri
Journal: Cancer Res Date: 2007-11-01 Impact factor: 12.701

7. c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma.

Authors: Menggui Huang; Tianrun Liu; Peihong Ma; R Alan Mitteer; Zhenting Zhang; Hyun Jun Kim; Eujin Yeo; Duo Zhang; Peiqiang Cai; Chunsheng Li; Lin Zhang; Botao Zhao; Laura Roccograndi; Donald M O'Rourke; Nadia Dahmane; Yanqing Gong; Constantinos Koumenis; Yi Fan
Journal: J Clin Invest Date: 2016-04-04 Impact factor: 14.808

8. Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α.

Authors: Qirui Wang; Zhenqiang He; Menggui Huang; Tianrun Liu; Yanling Wang; Haineng Xu; Hao Duan; Peihong Ma; Lin Zhang; Scott S Zamvil; Juan Hidalgo; Zhenfeng Zhang; Donald M O'Rourke; Nadia Dahmane; Steven Brem; Yonggao Mou; Yanqing Gong; Yi Fan
Journal: Nat Commun Date: 2018-02-08 Impact factor: 14.919

9. PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma.

Authors: Tianrun Liu; Wenjuan Ma; Haineng Xu; Menggui Huang; Duo Zhang; Zhenqiang He; Lin Zhang; Steven Brem; Donald M O'Rourke; Yanqing Gong; Yonggao Mou; Zhenfeng Zhang; Yi Fan
Journal: Nat Commun Date: 2018-08-27 Impact factor: 14.919

10. Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6⁺ cancer cell and macrophage polarization.

Authors: Seo-Hyun Choi; A-Ram Kim; Jae-Kyung Nam; Jin-Mo Kim; Jee-Youn Kim; Haeng Ran Seo; Hae-June Lee; Jaeho Cho; Yoon-Jin Lee
Journal: Nat Commun Date: 2018-11-30 Impact factor: 14.919

7 in total

1. Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma.

Authors: Menggui Huang; Duo Zhang; Janet Y Wu; Kun Xing; Eujin Yeo; Chunsheng Li; Lin Zhang; Eric Holland; Lutian Yao; Ling Qin; Zev A Binder; Donald M O'Rourke; Steven Brem; Constantinos Koumenis; Yanqing Gong; Yi Fan
Journal: Sci Transl Med Date: 2020-02-26 Impact factor: 17.956

7. Calmodulin 2 Facilitates Angiogenesis and Metastasis of Gastric Cancer via STAT3/HIF-1A/VEGF-A Mediated Macrophage Polarization.

Authors: Ganggang Mu; Yijie Zhu; Zehua Dong; Lang Shi; Yunchao Deng; Hongyan Li
Journal: Front Oncol Date: 2021-09-15 Impact factor: 6.244