Literature DB >> 31420521

Cutting fuel offers new clues in diabetic mystery.

P Darrell Neufer1.   

Abstract

Competing theories have held opposite views on the role of flux through β-oxidation in causing insulin resistance. New transcriptomics, proteomics, and metabolomics data of skeletal muscle from mice in which lipid oxidation is limited by restricting entry of fat into mitochondria reveal extensive remodeling of metabolic pathways, consistent with an overall reduction in metabolic efficiency and improved metabolic health. These findings point to a potential new therapeutic approach for treating insulin resistance and type 2 diabetes.
© 2019 Neufer.

Entities:  

Mesh：

Year:  2019        PMID： 31420521      PMCID： PMC6699854          DOI： 10.1074/jbc.H119.010075

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  10 in total

Review 1.  Linking mitochondrial bioenergetics to insulin resistance via redox biology.

Authors:  Kelsey H Fisher-Wellman; P Darrell Neufer
Journal:  Trends Endocrinol Metab       Date:  2012-02-02       Impact factor: 12.015

2.  Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake.

Authors:  David P Olson; Thomas Pulinilkunnil; Gary W Cline; Gerald I Shulman; Bradford B Lowell
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-05       Impact factor: 11.205

3.  Mitochondrial dysfunction and type 2 diabetes.

Authors:  Bradford B Lowell; Gerald I Shulman
Journal:  Science       Date:  2005-01-21       Impact factor: 47.728

4.  Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism.

Authors:  Shawna E Wicks; Bolormaa Vandanmagsar; Kimberly R Haynie; Scott E Fuller; Jaycob D Warfel; Jacqueline M Stephens; Miao Wang; Xianlin Han; Jingying Zhang; Robert C Noland; Randall L Mynatt
Journal:  Proc Natl Acad Sci U S A       Date:  2015-06-08       Impact factor: 11.205

5.  Extensive metabolic remodeling after limiting mitochondrial lipid burden is consistent with an improved metabolic health profile.

Authors:  Sujoy Ghosh; Shawna E Wicks; Bolormaa Vandanmagsar; Tamra M Mendoza; David S Bayless; J Michael Salbaum; Stephen P Dearth; Shawn R Campagna; Randall L Mynatt; Robert C Noland
Journal:  J Biol Chem       Date:  2019-05-16       Impact factor: 5.157

6.  Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence.

Authors:  James P Boyle; Theodore J Thompson; Edward W Gregg; Lawrence E Barker; David F Williamson
Journal:  Popul Health Metr       Date:  2010-10-22

7.  Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets.

Authors:  Lutfi Abu-Elheiga; Wonkeun Oh; Parichher Kordari; Salih J Wakil
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-14       Impact factor: 11.205

8.  Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity.

Authors:  Kyle L Hoehn; Nigel Turner; Michael M Swarbrick; Donna Wilks; Elaine Preston; Yuwei Phua; Himani Joshi; Stuart M Furler; Mark Larance; Bronwyn D Hegarty; Simon J Leslie; Russell Pickford; Andrew J Hoy; Edward W Kraegen; David E James; Gregory J Cooney
Journal:  Cell Metab       Date:  2010-01       Impact factor: 27.287

9.  Lipid-induced mitochondrial stress and insulin action in muscle.

Authors:  Deborah M Muoio; P Darrell Neufer
Journal:  Cell Metab       Date:  2012-05-02       Impact factor: 27.287

10.  A low fat diet ameliorates pathology but retains beneficial effects associated with CPT1b knockout in skeletal muscle.

Authors:  Jaycob D Warfel; Bolormaa Vandanmagsar; Shawna E Wicks; Jingying Zhang; Robert C Noland; Randall L Mynatt
Journal:  PLoS One       Date:  2017-12-14       Impact factor: 3.240
  10 in total
  3 in total

1.  Metabolic and Signaling Roles of Ketone Bodies in Health and Disease.

Authors:  Patrycja Puchalska; Peter A Crawford
Journal:  Annu Rev Nutr       Date:  2021-10-11       Impact factor: 9.323

2.  Genetically increasing flux through β-oxidation in skeletal muscle increases mitochondrial reductive stress and glucose intolerance.

Authors:  Cody D Smith; Chien-Te Lin; Shawna L McMillin; Luke A Weyrauch; Cameron A Schmidt; Cheryl A Smith; Irwin J Kurland; Carol A Witczak; P Darrell Neufer
Journal:  Am J Physiol Endocrinol Metab       Date:  2021-04-05       Impact factor: 4.310

3.  High metabolic substrate load induces mitochondrial dysfunction in rat skeletal muscle microvascular endothelial cells.

Authors:  Camilla Hansen; Karina Olsen; Henriette Pilegaard; Jens Bangsbo; Lasse Gliemann; Ylva Hellsten
Journal:  Physiol Rep       Date:  2021-07
  3 in total

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