Literature DB >> 15662004

Mitochondrial dysfunction and type 2 diabetes.

Bradford B Lowell1, Gerald I Shulman.   

Abstract

Maintenance of normal blood glucose levels depends on a complex interplay between the insulin responsiveness of skeletal muscle and liver and glucose-stimulated insulin secretion by pancreatic beta cells. Defects in the former are responsible for insulin resistance, and defects in the latter are responsible for progression to hyperglycemia. Emerging evidence supports the potentially unifying hypothesis that both of these prominent features of type 2 diabetes are caused by mitochondrial dysfunction.

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Year:  2005        PMID： 15662004     DOI： 10.1126/science.1104343

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  730 in total

1.  Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance.

Authors:  Laura Formentini; Alexander J Ryan; Manuel Gálvez-Santisteban; Leslie Carter; Pam Taub; John D Lapek; David J Gonzalez; Francisco Villarreal; Theodore P Ciaraldi; José M Cuezva; Robert R Henry
Journal:  Diabetologia       Date:  2017-08-02       Impact factor: 10.122

2.  Analyte flux at a biomaterial-tissue interface over time: implications for sensors for type 1 and 2 diabetes mellitus.

Authors:  Neda Rajamand Ekberg; Kerstin Brismar; Jonas Malmstedt; Mari-Anne Hedblad; Ulf Adamson; Urban Ungerstedt; Natalie Wisniewski
Journal:  J Diabetes Sci Technol       Date:  2010-09-01

3.  Hydrogen sulphide protects mouse pancreatic β-cells from cell death induced by oxidative stress, but not by endoplasmic reticulum stress.

Authors:  S Taniguchi; L Kang; T Kimura; I Niki
Journal:  Br J Pharmacol       Date:  2011-03       Impact factor: 8.739

4.  Mutation of the His ligand in mitoNEET stabilizes the 2Fe-2S cluster despite conformational heterogeneity in the ligand environment.

Authors:  Andrea R Conlan; Mark L Paddock; Christina Homer; Herbert L Axelrod; Aina E Cohen; Edward C Abresch; John A Zuris; Rachel Nechushtai; Patricia A Jennings
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2011-05-17

5.  Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion.

Authors:  Ryan J Mailloux; Accalia Fu; Christine Robson-Doucette; Emma M Allister; Michael B Wheeler; Robert Screaton; Mary-Ellen Harper
Journal:  J Biol Chem       Date:  2012-10-03       Impact factor: 5.157

6.  Maternal obesity downregulates myogenesis and beta-catenin signaling in fetal skeletal muscle.

Authors:  Jun F Tong; Xu Yan; Mei J Zhu; Stephen P Ford; Peter W Nathanielsz; Min Du
Journal:  Am J Physiol Endocrinol Metab       Date:  2009-01-27       Impact factor: 4.310

7.  Burn injury-induced IRS-1 degradation in mouse skeletal muscle.

Authors:  X-M Lu; Rg Tompkins; Aj Fischman
Journal:  Int J Burns Trauma       Date:  2013-01-24

Review 8.  DNA Damage, DNA Repair, Aging, and Neurodegeneration.

Authors:  Scott Maynard; Evandro Fei Fang; Morten Scheibye-Knudsen; Deborah L Croteau; Vilhelm A Bohr
Journal:  Cold Spring Harb Perspect Med       Date:  2015-09-18       Impact factor: 6.915

9.  Synergistic exacerbation of mitochondrial and synaptic dysfunction and resultant learning and memory deficit in a mouse model of diabetic Alzheimer's disease.

Authors:  Yongfu Wang; Long Wu; Jianping Li; Du Fang; Changjia Zhong; John Xi Chen; Shirley ShiDu Yan
Journal:  J Alzheimers Dis       Date:  2015       Impact factor: 4.472

10.  Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo.

Authors:  Shengnan Wu; Qiulun Lu; Ye Ding; Yin Wu; Yu Qiu; Pei Wang; Xiaoxiang Mao; Kai Huang; Zhonglin Xie; Ming-Hui Zou
Journal:  Circulation       Date:  2019-04-16       Impact factor: 29.690
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