Literature DB >> 31419294

Dose-Dependent Infectivity of Aseptic, Purified, Cryopreserved Plasmodium falciparum 7G8 Sporozoites in Malaria-Naive Adults.

Matthew B Laurens1, Andrea A Berry1, Mark A Travassos1, Kathy Strauss1, Matthew Adams1, Biraj Shrestha1, Tao Li2, Abraham Eappen2, Anita Manoj2, Yonas Abebe2, Tooba Murshedkar2, Anusha Gunasekera2, Thomas L Richie2, Kirsten E Lyke1, Christopher V Plowe3, Jessie K Kennedy4, Gail E Potter4, Gregory A Deye5, B K L Sim2, Stephen L Hoffman2.   

Abstract

Direct venous inoculation of 3.2 × 103 aseptic, purified, cryopreserved, vialed Plasmodium falciparum (Pf) strain NF54 sporozoites, PfSPZ Challenge (NF54), has been used for controlled human malaria infection (CHMI) in the United States, 4 European countries, and 6 African countries. In nonimmune adults, this results in 100% infection rates. We conducted a double-blind, randomized, dose-escalation study to assess the infectivity of the 7G8 clone of Pf (PfSPZ Challenge [7G8]). Results showed dose-dependent infectivity from 43% for 8 × 102 PfSPZ to 100% for 4.8 × 103 PfSPZ. PfSPZ Challenge (7G8) will allow for more complete assessment by CHMI of antimalarial vaccines and drugs.
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  zzm321990 Plasmodium falciparumzzm321990 ; controlled human malaria infection; cryopreservation; humans

Mesh：

Substances：

Year:  2019        PMID： 31419294      PMCID： PMC6834064          DOI： 10.1093/infdis/jiz410

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

1.  Protection against Plasmodium falciparum malaria by PfSPZ Vaccine.

Authors:  Judith E Epstein; Kristopher M Paolino; Thomas L Richie; Martha Sedegah; Alexandra Singer; Adam J Ruben; Sumana Chakravarty; April Stafford; Richard C Ruck; Abraham G Eappen; Tao Li; Peter F Billingsley; Anita Manoj; Joana C Silva; Kara Moser; Robin Nielsen; Donna Tosh; Susan Cicatelli; Harini Ganeshan; Jessica Case; Debbie Padilla; Silas Davidson; Lindsey Garver; Elizabeth Saverino; Tooba Murshedkar; Anusha Gunasekera; Patrick S Twomey; Sharina Reyes; James E Moon; Eric R James; Natasha Kc; Minglin Li; Esteban Abot; Arnel Belmonte; Kevin Hauns; Maria Belmonte; Jun Huang; Carlos Vasquez; Shon Remich; Mary Carrington; Yonas Abebe; Amy Tillman; Bradley Hickey; Jason Regules; Eileen Villasante; B Kim Lee Sim; Stephen L Hoffman
Journal:  JCI Insight       Date:  2017-01-12

2.  Infectivity to mosquitoes of Plasmodium falciparum clones grown in vitro from the same isolate.

Authors:  T R Burkot; J L Williams; I Schneider
Journal:  Trans R Soc Trop Med Hyg       Date:  1984       Impact factor: 2.184

3.  Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection.

Authors:  Kirsten E Lyke; Andrew S Ishizuka; Andrea A Berry; Sumana Chakravarty; Adam DeZure; Mary E Enama; Eric R James; Peter F Billingsley; Anusha Gunasekera; Anita Manoj; Minglin Li; Adam J Ruben; Tao Li; Abraham G Eappen; Richard E Stafford; Natasha Kc; Tooba Murshedkar; Floreliz H Mendoza; Ingelise J Gordon; Kathryn L Zephir; LaSonji A Holman; Sarah H Plummer; Cynthia S Hendel; Laura Novik; Pamela J M Costner; Jamie G Saunders; Nina M Berkowitz; Barbara J Flynn; Martha C Nason; Lindsay S Garver; Matthew B Laurens; Christopher V Plowe; Thomas L Richie; Barney S Graham; Mario Roederer; B Kim Lee Sim; Julie E Ledgerwood; Stephen L Hoffman; Robert A Seder
Journal:  Proc Natl Acad Sci U S A       Date:  2017-02-21       Impact factor: 11.205

4.  A consultation on the optimization of controlled human malaria infection by mosquito bite for evaluation of candidate malaria vaccines.

Authors:  Matthew B Laurens; Christopher J Duncan; Judith E Epstein; Adrian V Hill; Jack L Komisar; Kirsten E Lyke; Christian F Ockenhouse; Thomas L Richie; Meta Roestenberg; Robert W Sauerwein; Michele D Spring; Angela K Talley; Vasee S Moorthy
Journal:  Vaccine       Date:  2012-05-31       Impact factor: 3.641

Review 5.  The Promise of a Malaria Vaccine-Are We Closer?

Authors:  Matthew B Laurens
Journal:  Annu Rev Microbiol       Date:  2018-09-08       Impact factor: 15.500

6.  Controlled human malaria infections by intradermal injection of cryopreserved Plasmodium falciparum sporozoites.

Authors:  Meta Roestenberg; Else M Bijker; B Kim Lee Sim; Peter F Billingsley; Eric R James; Guido J H Bastiaens; Anne C Teirlinck; Anja Scholzen; Karina Teelen; Theo Arens; André J A M van der Ven; Anusha Gunasekera; Sumana Chakravarty; Soundarapandian Velmurugan; Cornelus C Hermsen; Robert W Sauerwein; Stephen L Hoffman
Journal:  Am J Trop Med Hyg       Date:  2012-11-13       Impact factor: 2.345

7.  Safety, Immunogenicity, and Protective Efficacy against Controlled Human Malaria Infection of Plasmodium falciparum Sporozoite Vaccine in Tanzanian Adults.

Authors:  Said A Jongo; Seif A Shekalaghe; L W Preston Church; Adam J Ruben; Tobias Schindler; Isabelle Zenklusen; Tobias Rutishauser; Julian Rothen; Anneth Tumbo; Catherine Mkindi; Maximillian Mpina; Ali T Mtoro; Andrew S Ishizuka; Kamaka Ramadhani Kassim; Florence A Milando; Munira Qassim; Omar A Juma; Solomon Mwakasungula; Beatus Simon; Eric R James; Yonas Abebe; Natasha Kc; Sumana Chakravarty; Elizabeth Saverino; Bakari M Bakari; Peter F Billingsley; Robert A Seder; Claudia Daubenberger; B Kim Lee Sim; Thomas L Richie; Marcel Tanner; Salim Abdulla; Stephen L Hoffman
Journal:  Am J Trop Med Hyg       Date:  2018-06-21       Impact factor: 3.707

8.  Controlled human malaria infection of Tanzanians by intradermal injection of aseptic, purified, cryopreserved Plasmodium falciparum sporozoites.

Authors:  Seif Shekalaghe; Mastidia Rutaihwa; Peter F Billingsley; Mwajuma Chemba; Claudia A Daubenberger; Eric R James; Maximillian Mpina; Omar Ali Juma; Tobias Schindler; Eric Huber; Anusha Gunasekera; Anita Manoj; Beatus Simon; Elizabeth Saverino; L W Preston Church; Cornelus C Hermsen; Robert W Sauerwein; Christopher Plowe; Meera Venkatesan; Philip Sasi; Omar Lweno; Paul Mutani; Ali Hamad; Ali Mohammed; Alwisa Urassa; Tutu Mzee; Debbie Padilla; Adam Ruben; B Kim Lee Sim; Marcel Tanner; Salim Abdulla; Stephen L Hoffman
Journal:  Am J Trop Med Hyg       Date:  2014-07-28       Impact factor: 2.345

9.  An ultrasensitive reverse transcription polymerase chain reaction assay to detect asymptomatic low-density Plasmodium falciparum and Plasmodium vivax infections in small volume blood samples.

Authors:  Matthew Adams; Sudhaunshu N Joshi; Gillian Mbambo; Amy Z Mu; Shay M Roemmich; Biraj Shrestha; Kathy A Strauss; Nicole Eddington Johnson; Khine Zaw Oo; Tin Maung Hlaing; Zay Yar Han; Kay Thwe Han; Si Thura; Adam K Richards; Fang Huang; Myaing M Nyunt; Christopher V Plowe
Journal:  Malar J       Date:  2015-12-23       Impact factor: 2.979

10.  Controlled Human Malaria Infection with Graded Numbers of Plasmodium falciparum NF135.C10- or NF166.C8-Infected Mosquitoes.

Authors:  Marijke C C Langenberg; Linda J Wammes; Matthew B B McCall; Else M Bijker; Geert-Jan van Gemert; Wouter Graumans; Marga G van de Vegte-Bolmer; Karina Teelen; Cornelis C Hermsen; Rob Koelewijn; Jaap J van Hellemond; Perry J J van Genderen; Robert W Sauerwein
Journal:  Am J Trop Med Hyg       Date:  2018-07-12       Impact factor: 2.345
View more
  9 in total

Review 1.  Controlled Human Infection Models To Accelerate Vaccine Development.

Authors:  Robert K M Choy; A Louis Bourgeois; Christian F Ockenhouse; Richard I Walker; Rebecca L Sheets; Jorge Flores
Journal:  Clin Microbiol Rev       Date:  2022-07-06       Impact factor: 50.129

2.  Plasmodium falciparum 7G8 challenge provides conservative prediction of efficacy of PfNF54-based PfSPZ Vaccine in Africa.

Authors:  Joana C Silva; Ankit Dwivedi; Kara A Moser; Mahamadou S Sissoko; Judith E Epstein; Sara A Healy; Kirsten E Lyke; Benjamin Mordmüller; Peter G Kremsner; Patrick E Duffy; Tooba Murshedkar; B Kim Lee Sim; Thomas L Richie; Stephen L Hoffman
Journal:  Nat Commun       Date:  2022-06-13       Impact factor: 17.694

Review 3.  Fast and fierce versus slow and smooth: Heterogeneity in immune responses to Plasmodium in the controlled human malaria infection model.

Authors:  Xi Zen Yap; Matthew B B McCall; Robert W Sauerwein
Journal:  Immunol Rev       Date:  2019-10-12       Impact factor: 12.988

4.  Multi-Dose Priming Regimens of PfSPZ Vaccine: Safety and Efficacy against Controlled Human Malaria Infection in Equatoguinean Adults.

Authors:  Said Abdallah Jongo; L W Preston Church; Vicente Urbano Nsue Ndong Nchama; Ali Hamad; Raul Chuquiyauri; Kamaka Ramadhani Kassim; Thabit Athuman; Anna Deal; K C Natasha; Ali Mtoro; Maxmillian Mpina; Elizabeth Nyakarungu; Gertrudis Owono Bidjimi; Marta Alene Owono; Escolastica Raquel Mansogo Maye; Martin Eka Ondo Mangue; Genaro Nsue Nguema Okomo; Beltran Ekua Ntutumu Pasialo; Dolores Mbang Ondó Mandumbi; María-Silvia A López Mikue; Fortunata Lobede Mochomuemue; Mariano Obiang Obono; Juan Carlos Momo Besaha; José Raso Bijeri; Gabriel Mba Abegue; Yolanda Rimoy Veri; Ines Toichoa Bela; Federico Comsil Chochi; José Enrique Lima Sánchez; Vanessa Pencelli; Griselda Gayozo; Jose Antonio Esono Mba Nlang; Tobias Schindler; Eric R James; Yonas Abebe; Laurence Lemiale; Thomas C Stabler; Tooba Murshedkar; Mei-Chun Chen; Christopher Schwabe; Josea Ratsirarson; Matilde Riloha Rivas; Mitoha Ondo'o Ayekaba; Diosdado Vicente Nsue Milang; Carlos Cortes Falla; Wonder P Phiri; Guillermo A García; Carl D Maas; Bonifacio Manguire Nlavo; Marcel Tanner; Peter F Billingsley; B Kim Lee Sim; Claudia Daubenberger; Stephen L Hoffman; Salim Abdulla; Thomas L Richie
Journal:  Am J Trop Med Hyg       Date:  2022-02-07       Impact factor: 2.345

5.  A PfSPZ vaccine immunization regimen equally protective against homologous and heterologous controlled human malaria infection.

Authors:  Stephen L Hoffman; Peter G Kremsner; Benjamin Mordmüller; Zita Sulyok; Mihály Sulyok; Zsofia Molnar; Albert Lalremruata; Carlos Lamsfus Calle; Patricia Granados Bayon; Meral Esen; Markus Gmeiner; Jana Held; Henri-Lynn Heimann; Tamirat Gebru Woldearegai; Javier Ibáñez; Judith Flügge; Rolf Fendel; Andrea Kreidenweiss; Natasha Kc; Tooba Murshedkar; Sumana Chakravarty; Pouria Riyahi; Peter F Billingsley; L W Preston Church; Thomas L Richie; B Kim Lee Sim
Journal:  NPJ Vaccines       Date:  2022-08-23       Impact factor: 9.399

Review 6.  Five decades of clinical assessment of whole-sporozoite malaria vaccines.

Authors:  Helena Nunes-Cabaço; Diana Moita; Miguel Prudêncio
Journal:  Front Immunol       Date:  2022-09-08       Impact factor: 8.786

7.  Efficient infection of non-human primates with purified, cryopreserved Plasmodium knowlesi sporozoites.

Authors:  Sumana Chakravarty; Melanie J Shears; Eric R James; Urvashi Rai; Natasha Kc; Solomon Conteh; Lynn E Lambert; Patrick E Duffy; Sean C Murphy; Stephen L Hoffman
Journal:  Malar J       Date:  2022-08-27       Impact factor: 3.469

8.  Intrinsic multiplication rate variation and plasticity of human blood stage malaria parasites.

Authors:  Lindsay B Stewart; Ofelia Diaz-Ingelmo; Antoine Claessens; James Abugri; Richard D Pearson; Sonia Goncalves; Eleanor Drury; Dominic P Kwiatkowski; Gordon A Awandare; David J Conway
Journal:  Commun Biol       Date:  2020-10-28

9.  Diagnostic performance and comparison of ultrasensitive and conventional rapid diagnostic test, thick blood smear and quantitative PCR for detection of low-density Plasmodium falciparum infections during a controlled human malaria infection study in Equatorial Guinea.

Authors:  Thomas L Richie; Claudia A Daubenberger; Maxmillian Mpina; Thomas C Stabler; Tobias Schindler; Jose Raso; Anna Deal; Ludmila Acuche Pupu; Elizabeth Nyakarungu; Maria Del Carmen Ovono Davis; Vicente Urbano; Ali Mtoro; Ali Hamad; Maria Silvia A Lopez; Beltran Pasialo; Marta Alene Owono Eyang; Matilde Riloha Rivas; Carlos Cortes Falla; Guillermo A García; Juan Carlos Momo; Raul Chuquiyauri; Elizabeth Saverino; L W Preston Church; B Kim Lee Sim; Bonifacio Manguire; Marcel Tanner; Carl Maas; Salim Abdulla; Peter F Billingsley; Stephen L Hoffman; Said Jongo
Journal:  Malar J       Date:  2022-03-24       Impact factor: 2.979
  9 in total

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