Literature DB >> 31417665

Fluorescent Imidazo[1,5-a]pyridinium Salt for a Potential Cancer Therapy Agent.

Fumitoshi Yagishita1,2, Jun-Ichi Tanigawa1, Chiho Nii1, Atsushi Tabata3, Hideaki Nagamune3, Hiroki Takanari4, Yasushi Imada1, Yasuhiko Kawamura1.   

Abstract

N,N'-Dimethylated imidazo[1,5-a]pyridinium salt having good water solubility and exhibiting fluorescence emission was found to work as not only a bioimaging agent but also a therapeutic agent under UVA-LED irradiation conditions. Because the continuous UVA-LED irradiation to HeLa cells stained by the synthesized salt resulted in the cell death due to the mitochondrial damage, the salt has a potential application as photodynamic therapy agent against tumor cells.

Entities:  

Year:  2019        PMID： 31417665      PMCID： PMC6693471          DOI： 10.1021/acsmedchemlett.9b00034

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  22 in total

1.  Photochemical internalization: a novel technology for delivery of macromolecules into cytosol.

Authors:  K Berg; P K Selbo; L Prasmickaite; T E Tjelle; K Sandvig; J Moan; G Gaudernack; O Fodstad; S Kjølsrud; H Anholt; G H Rodal; S K Rodal; A Høgset
Journal:  Cancer Res       Date:  1999-03-15       Impact factor: 12.701

2.  Visible light-induced nuclease activity of a ternary mono-phenanthroline copper(II) complex containing L-methionine as a photosensitizer.

Authors:  Ashis K Patra; Shanta Dhar; Munirathinam Nethaji; Akhil R Chakravarty
Journal:  Chem Commun (Camb)       Date:  2003-07-07       Impact factor: 6.222

3.  Photo-acceleration of protein release from endosome in the protein transduction system.

Authors:  Masayuki Matsushita; Hirofumi Noguchi; Yun-Fei Lu; Kazuhito Tomizawa; Hiroyuki Michiue; Sheng-Tian Li; Kenzo Hirose; Susan Bonner-Weir; Hideki Matsui
Journal:  FEBS Lett       Date:  2004-08-13       Impact factor: 4.124

4.  Specific redistribution of cell-penetrating peptides from endosomes to the cytoplasm and nucleus upon laser illumination.

Authors:  James R Maiolo; Elizabeth A Ottinger; Marc Ferrer
Journal:  J Am Chem Soc       Date:  2004-12-01       Impact factor: 15.419

Review 5.  Activatable photosensitizers for imaging and therapy.

Authors:  Jonathan F Lovell; Tracy W B Liu; Juan Chen; Gang Zheng
Journal:  Chem Rev       Date:  2010-05-12       Impact factor: 60.622

6.  Studies on the mechanism of the photo-induced DNA damage in the presence of acridizinium salts-involvement of singlet oxygen and an unusual source for hydroxyl radicals.

Authors:  Cornelia Bohne; Katja Faulhaber; Bernd Giese; Angelika Häfner; Andrea Hofmann; Heiko Ihmels; Anne-Kathrin Köhler; Saana Perä; Friedemann Schneider; Molina A L Sheepwash
Journal:  J Am Chem Soc       Date:  2005-01-12       Impact factor: 15.419

7.  Direct photo-induced DNA strand scission by a ruthenium bipyridyl complex.

Authors:  Eylon Yavin; Eric D A Stemp; Lev Weiner; Irit Sagi; Rina Arad-Yellin; Abraham Shanzer
Journal:  J Inorg Biochem       Date:  2004-11       Impact factor: 4.155

Review 8.  Photodynamic therapy for cancer.

Authors:  Dennis E J G J Dolmans; Dai Fukumura; Rakesh K Jain
Journal:  Nat Rev Cancer       Date:  2003-05       Impact factor: 60.716

9.  Ternary iron(III) complex showing photocleavage of DNA in the photodynamic therapy window.

Authors:  Mithun Roy; Sounik Saha; Ashis K Patra; Munirathinam Nethaji; Akhil R Chakravarty
Journal:  Inorg Chem       Date:  2007-05-01       Impact factor: 5.165

10.  Uptake and accumulation of 1-methyl-4-phenylpyridinium by rat liver mitochondria measured using an ion-selective electrode.

Authors:  G P Davey; K F Tipton; M P Murphy
Journal:  Biochem J       Date:  1992-12-01       Impact factor: 3.857
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  1 in total

1.  Imidazo[1,5-a]pyridine-Based Fluorescent Probes: A Photophysical Investigation in Liposome Models.

Authors:  Giacomo Renno; Francesca Cardano; Giorgio Volpi; Claudia Barolo; Guido Viscardi; Andrea Fin
Journal:  Molecules       Date:  2022-06-16       Impact factor: 4.927
  1 in total

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