We report diverse C-N cross-coupling reactions of aryl thianthrenium salts that are formed site-selectively by direct C-H functionalization. The scope of N-nucleophiles ranges from primary and secondary alkyl and aryl amines to various N-containing heterocycles, and the overall transformation is applicable to late-stage functionalization of complex, drug-like small molecules.
We report diverse C-N cross-coupling reactions of n class="Chemical">aryl thianthrenium salts that are formed site-selectively by direct C-H functionalization. The scope of N-nucleophiles ranges from primary and secondary alkyl and aryl amines to various N-containing heterocycles, and the overall transformation is applicable to late-stage functionalization of complex, drug-like small molecules.
Authors: Kevin Kafuta; André Korzun; Marvin Böhm; Christopher Golz; Manuel Alcarazo Journal: Angew Chem Int Ed Engl Date: 2019-11-26 Impact factor: 15.336