Valentina Ivezaj1, Stephen C Benoit2, Jon Davis3, Scott Engel4, Celia Lloret-Linares5, James E Mitchell6, M Yanina Pepino7, Ann M Rogers8, Kristine Steffen4, Stephanie Sogg9,10. 1. Yale School of Medicine, 301 Cedar Street, 2nd Floor, New Haven, CT, 06519, USA. valentina.ivezaj@yale.edu. 2. University of Cincinnati, Cincinnati, OH, 45237, USA. 3. Washington State University, Pullman, WA, 99164, USA. 4. Sanford Research, Fargo, ND, 58103, USA. 5. Maladies Nutritionnelles et métaboliques, Ramsay-Générale de Santé, Hôpital Privé Pays de Savoie, 74105, Annemasse, France. 6. University of North Dakota School of Medicine and Health Sciences, Fargo, ND, 58202, USA. 7. University of Illinois at Urbana Champaign, Urbana, IL, 61801, USA. 8. Penn State Health Milton S Hershey Medical Center, Hershey, PA, 17033, USA. 9. Massachusetts General Hospital Weight Center, Boston, MA, 02114, USA. 10. Harvard Medical School, Boston, MA, 02115, USA.
Abstract
PURPOSE OF REVIEW: This review synthesized the literature on predictors and mechanisms of post-bariatric alcohol problems, in order to guide future research on prevention and treatment targets. RECENT FINDINGS: Consistent evidence suggests an elevated risk of developing problems with alcohol following bariatric surgery. While there is a paucity of empirical data on predictors of problematic alcohol use after bariatric surgery, being male, a younger age, smoking, regular alcohol consumption, pre-surgical alcohol use disorder, and a lower sense of belonging have predicted alcohol misuse post-operatively. This review synthesizes potential mechanisms including specific bariatric surgical procedures, peptides and reinforcement/reward pathways, pharmacokinetics, and genetic influences. Finally, potential misperceptions regarding mechanisms are explored. Certain bariatric procedures elevate the risk of alcohol misuse post-operatively. Future research should serve to elucidate the complexities of reward signaling, genetically mediated mechanisms, and pharmacokinetics in relation to alcohol use across gender and developmental period by surgery type.
PURPOSE OF REVIEW: This review synthesized the literature on predictors and mechanisms of post-bariatric alcohol problems, in order to guide future research on prevention and treatment targets. RECENT FINDINGS: Consistent evidence suggests an elevated risk of developing problems with alcohol following bariatric surgery. While there is a paucity of empirical data on predictors of problematic alcohol use after bariatric surgery, being male, a younger age, smoking, regular alcohol consumption, pre-surgical alcohol use disorder, and a lower sense of belonging have predicted alcohol misuse post-operatively. This review synthesizes potential mechanisms including specific bariatric surgical procedures, peptides and reinforcement/reward pathways, pharmacokinetics, and genetic influences. Finally, potential misperceptions regarding mechanisms are explored. Certain bariatric procedures elevate the risk of alcohol misuse post-operatively. Future research should serve to elucidate the complexities of reward signaling, genetically mediated mechanisms, and pharmacokinetics in relation to alcohol use across gender and developmental period by surgery type.
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