Literature DB >> 31409704

Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors.

Anjana Srivatsan1, Binzhong Li1, Dafne N Sanchez1, Steven B Somach1, Vandeclecio L da Silva2,3, Sandro J de Souza2,3, Christopher D Putnam1,4, Richard D Kolodner5,6,7,8.   

Abstract

Gross Chromosomal Rearrangements (GCRs) play an important role in human diseases, including cancer. Although most of the nonessential Genome Instability Suppressing (GIS) genes in Saccharomyces cerevisiae are known, the essential genes in which mutations can cause increased GCR rates are not well understood. Here 2 S. cerevisiae GCR assays were used to screen a targeted collection of temperature-sensitive mutants to identify mutations that caused increased GCR rates. This identified 94 essential GIS (eGIS) genes in which mutations cause increased GCR rates and 38 candidate eGIS genes that encode eGIS1 protein-interacting or family member proteins. Analysis of TCGA data using the human genes predicted to encode the proteins and protein complexes implicated by the S. cerevisiae eGIS genes revealed a significant enrichment of mutations affecting predicted human eGIS genes in 10 of the 16 cancers analyzed.

Entities:  

Keywords:  cancer; chromosome dynamics and replication; genome instability

Mesh：

Substances：

Year:  2019        PMID： 31409704      PMCID： PMC6717276          DOI： 10.1073/pnas.1906921116

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  64 in total

1.  Telomere dysfunction increases mutation rate and genomic instability.

Authors:  J A Hackett; D M Feldser; C W Greider
Journal:  Cell       Date:  2001-08-10       Impact factor: 41.582

2.  Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae.

Authors:  K Myung; C Chen; R D Kolodner
Journal:  Nature       Date:  2001-06-28       Impact factor: 49.962

3.  Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae.

Authors:  Stephanie Smith; Ji-Young Hwang; Soma Banerjee; Anju Majeed; Amitabha Gupta; Kyungjaem Myung
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-07       Impact factor: 11.205

4.  A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits.

Authors:  Tracy A Nissan; Kyriaki Galani; Bohumil Maco; David Tollervey; Ueli Aebi; Ed Hurt
Journal:  Mol Cell       Date:  2004-07-23       Impact factor: 17.970

5.  Chromosome healing through terminal deletions generated by de novo telomere additions in Saccharomyces cerevisiae.

Authors:  Christopher D Putnam; Vincent Pennaneach; Richard D Kolodner
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-24       Impact factor: 11.205

6.  Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae.

Authors:  K Myung; A Datta; R D Kolodner
Journal:  Cell       Date:  2001-02-09       Impact factor: 41.582

Review 7.  A mutator phenotype in cancer.

Authors:  L A Loeb
Journal:  Cancer Res       Date:  2001-04-15       Impact factor: 12.701

8.  NORF5/HUG1 is a component of the MEC1-mediated checkpoint response to DNA damage and replication arrest in Saccharomyces cerevisiae.

Authors:  M A Basrai; V E Velculescu; K W Kinzler; P Hieter
Journal:  Mol Cell Biol       Date:  1999-10       Impact factor: 4.272

9.  Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants.

Authors:  C Chen; R D Kolodner
Journal:  Nat Genet       Date:  1999-09       Impact factor: 38.330

10.  A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations.

Authors:  Meng-Er Huang; Anne-Gaelle Rio; Alain Nicolas; Richard D Kolodner
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-12       Impact factor: 11.205
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  5 in total

1.  FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination.

Authors:  Elaine Guo; Yuki Ishii; James Mueller; Anjana Srivatsan; Timothy Gahman; Christopher D Putnam; Jean Y J Wang; Richard D Kolodner
Journal:  Proc Natl Acad Sci U S A       Date:  2020-07-27       Impact factor: 11.205

Review 2.  Origin, Regulation, and Fitness Effect of Chromosomal Rearrangements in the Yeast Saccharomyces cerevisiae.

Authors:  Xing-Xing Tang; Xue-Ping Wen; Lei Qi; Yang Sui; Ying-Xuan Zhu; Dao-Qiong Zheng
Journal:  Int J Mol Sci       Date:  2021-01-14       Impact factor: 5.923

3.  Shared and distinct roles of Esc2 and Mms21 in suppressing genome rearrangements and regulating intracellular sumoylation.

Authors:  Raymond T Suhandynata; Yong-Qi Gao; Ann L Zhou; Yusheng Yang; Pang-Che Wang; Huilin Zhou
Journal:  PLoS One       Date:  2021-02-18       Impact factor: 3.240

4.  Site-specific MCM sumoylation prevents genome rearrangements by controlling origin-bound MCM.

Authors:  Yun Quan; Qian-Yi Zhang; Ann L Zhou; Yuhao Wang; Jiaxi Cai; Yong-Qi Gao; Huilin Zhou
Journal:  PLoS Genet       Date:  2022-06-13       Impact factor: 6.020

5.  DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis.

Authors:  Xiangzhou Meng; Lei Wei; Sujan Devbhandari; Tuo Zhang; Jenny Xiang; Dirk Remus; Xiaolan Zhao
Journal:  Nat Commun       Date:  2020-05-15       Impact factor: 14.919
  5 in total

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