Literature DB >> 3140813

Different types of ADP-ribose protein bonds formed by botulinum C2 toxin, botulinum ADP-ribosyltransferase C3 and pertussis toxin.

K Aktories1, I Just, W Rosenthal.   

Abstract

We attempted to characterize ADP-ribose-amino acid bonds formed by various bacterial toxins. The ADP-ribose-arginine bond formed by botulinum C2 toxin in actin was cleaved with a half-life of about 2 h by treatment with hydroxylamine (0.5 M). In contrast, the ADP-ribose-cysteine bond formed by pertussis toxin in transducin and the ADP-ribose-amino acid linkage formed by botulinum ADP-ribosyltransferase C3 in platelet cytosolic proteins were not affected by hydroxylamine. HgCl2 cleaved the ADP-ribose-amino acid bond formed by pertussis toxin in transducin but not those formed by botulinum C2 toxin or botulinum ADP-ribosyltransferase C3 in actin and platelet cytosolic proteins, respectively. NaOH (0.5 M) cleaved the ADP-ribose-amino acid bonds formed by botulinum C2 toxin and pertussis toxin but not the one formed by botulinum ADP-ribosyltransferase C3. The data indicate that the ADP-ribose bond formed by botulinum ADP-ribosyltransferase C3 differs from those formed by the known bacterial ADP-ribosylating toxins.

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Year:  1988        PMID： 3140813     DOI： 10.1016/s0006-291x(88)80849-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

Review 1.  Clostridial ADP-ribosyltransferases--modification of low molecular weight GTP-binding proteins and of actin by clostridial toxins.

Authors:  K Aktories
Journal:  Med Microbiol Immunol       Date:  1990       Impact factor: 3.402

2.  Endogenous ADP-ribosylation of proteins in Mycobacterium smegmatis.

Authors:  M H Serres; J C Ensign
Journal:  J Bacteriol       Date:  1996-10       Impact factor: 3.490

3.  Ecto-ADP-ribosyltransferase activity of Pseudomonas aeruginosa exoenzyme S.

Authors:  D A Knight; J T Barbieri
Journal:  Infect Immun       Date:  1997-08       Impact factor: 3.441

4.  Molecular and biological characterization of Streptococcal SpyA-mediated ADP-ribosylation of intermediate filament protein vimentin.

Authors:  Laura M Icenogle; Shawna M Hengel; Lisette H Coye; Amber Streifel; Carleen M Collins; David R Goodlett; Steve L Moseley
Journal:  J Biol Chem       Date:  2012-05-01       Impact factor: 5.157

5.  ADP-ribosylation of Drosophila indirect-flight-muscle actin and arthrin by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin.

Authors:  I Just; E S Hennessey; D R Drummond; K Aktories; J C Sparrow
Journal:  Biochem J       Date:  1993-04-15       Impact factor: 3.857

6.  Stimulation of endogenous ADP-ribosylation by brefeldin A.

Authors:  M A De Matteis; M Di Girolamo; A Colanzi; M Pallas; G Di Tullio; L J McDonald; J Moss; G Santini; S Bannykh; D Corda
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-01       Impact factor: 11.205

Review 7.  Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins.

Authors:  K Aktories
Journal:  Mol Cell Biochem       Date:  1994-09       Impact factor: 3.396

8.  Inactivation of the elongation factor Tu by mosquitocidal toxin-catalyzed mono-ADP-ribosylation.

Authors:  Jörg Schirmer; Hans-Joachim Wieden; Marina V Rodnina; Klaus Aktories
Journal:  Appl Environ Microbiol       Date:  2002-10       Impact factor: 4.792

9.  Nitric oxide stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase.

Authors:  J Zhang; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-15       Impact factor: 11.205

10.  ADP-ribosylation of an approximately 70-kilodalton protein of Klebsiella pneumoniae.

Authors:  U Geipel; I Just; K Aktories
Journal:  Infect Immun       Date:  1996-05       Impact factor: 3.441
  10 in total

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