| Literature DB >> 31407584 |
Jing Shi1, Xiang Xu1, Er Juan Zhao1, Bo Zhang1, Wei Li1, Yang Zhao1, Rui Hua Jiao1, Ren Xiang Tan1,2, Hui Ming Ge1.
Abstract
A cyclodipeptide synthase-containing gene cluster (pcm) was identified in Streptomyces chrestomyceticus NA4264 through genome mining. Heterologous expression of the cryptic pcm gene cluster in Streptomyces albus led to the production of a new highly modified cyclodipeptide named purincyclamide (1). Bioinformatic analysis and gene knockout experiments revealed the biosynthetic pathway. The production of 1 was achieved through a one-pot enzymatic reaction.Entities:
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Year: 2019 PMID： 31407584 DOI： 10.1021/acs.orglett.9b02461
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005