| Literature DB >> 31402360 |
Mylène Richard1, Charles Truillet, Vu Long Tran, Hui Liu, Karine Porte, Davide Audisio, Mélanie Roche, Benoit Jego, Sophie Cholet, François Fenaille, Bertrand Kuhnast, Frédéric Taran, Simon Specklin.
Abstract
We report the first pretargeting in vivo study using the Strain-Promoted Sydnone-Alkyne Cycloaadition (SPSAC) reaction. The injection of a fluorine-18 labeled cyclooctyne three days after cetuximab bearing chlorosydnone moieties allowed a significant detection of the tumor by PET imaging suggesting an efficient click reaction inside the tumoral site. With a kinetic constant superior to 300 M-1 s-1, the SPSAC reaction might be an interesting tool, in addition to tetrazine-cyclooctene ligation, for in vivo chemistry.Entities:
Mesh：
Substances：
Year: 2019 PMID： 31402360 DOI： 10.1039/c9cc05486c
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222