Green encapsulation of LDH(Zn/Al)-5-Fu with carboxymethyl cellulose biopolymer; new nanovehicle for oral colorectal cancer treatment.

Due to the decrease of the drugs side effects in controlled drug delivery systems, today's many research has been focused on designing the new controlled drug delivery systems. The main aim of the present work was the improving of the layered double hydroxide (LDH) properties as a drug delivery system through the encapsulation with carboxymethyl cellulose (CMC). In the first section, 5-fluorouracil (5-Fu) as a colon anticancer drug was loaded in LDH(Zn/Al) (about 87%). The FT-IR, SEM, and XRD analysis were used to probe the successful synthesis of LDH(Zn/Al) and 5-Fu loading in it. In the following, the nanohybrid encapsulated with CMC, through the crosslinking of the LDH(Zn/Al)-5-Fu and CMC mixture with Fe(III) as a physical crosslinker and CMC/LDH(Zn/Al)-5-Fu hydrogel beads were formed. From comparing of the 5-Fu release from the LDH(Zn/Al)-5-Fu and CMC/LDH(Zn/Al)-5-Fu hydrogel beads, it was found that the use of CMC as a capsule induce the controlled and sustained drug release behavior to the system. MTT assay approved the biocompatibility of the CMC/LDH(Zn/Al)-5-Fu hydrogel beads. With considering the swelling, drug loading, drug-releasing, and MTT assay results, the prepared CMC/LDH(Zn/Al)-5-Fu hydrogel beads system could be proposed as a potentially safe oral delivery system for colon cancer therapy.