Jeremiah Easley1, Christian Puttlitz2, Eileen Hackett1, Cecily Broomfield2, Lucas Nakamura2, Michael Hawes3, Charles Getz4, Mark Frankle5, Patrick St Pierre6, Robert Tashjian7, P Dean Cummings8, Joseph Abboud9, Derek Harper10, Kirk McGilvray11. 1. Preclinical Surgical Research Laboratory, Colorado State University, Fort Collins, CO, USA. 2. Orthopedic Bioengineering Research Laboratory, Colorado State University, Fort Collins, CO, USA. 3. Charter Preclinical Services, Hudson, MA, USA. 4. Orthopedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA. 5. Florida Orthopaedic Institute, Shoulder and Elbow Service, Tampa, FL, USA; Morsani College of Medicine, University of South Florida, Tampa, FL, USA. 6. Shoulder and Elbow Service, Desert Orthopedic Center, Eisenhower Health, Rancho Mirage, CA, USA. 7. University of Utah School of Medicine, Salt Lake City, UT, USA. 8. The Orthopedic Clinic Association, Phoenix, AZ, USA. 9. The Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA. 10. Zimmer Biomet, Warsaw, IN, USA. 11. Orthopedic Bioengineering Research Laboratory, Colorado State University, Fort Collins, CO, USA. Electronic address: kirk.mcgilvray@colostate.edu.
Abstract
BACKGROUND: The purpose of this study was to evaluate the biomechanical and histologic properties of rotator cuff repairs using a vented anchor attached to a bioresorbable interpositional scaffold composed of aligned PLGA (poly(l-lactide-co-glycoside)) microfibers in an animal model compared to standard anchors in an ovine model. METHODS: Fifty-six (n = 56) skeletally mature sheep were randomly assigned to a repair of an acute infraspinatus tendon detachment using a innovative anchor-PLGA scaffold device (Treatment) or a similar anchor without the scaffold (Control). Animals were humanely euthanized at 7 and 12 weeks post repair. Histologic and biomechanical properties of the repairs were evaluated and compared. RESULTS: The Treatment group had a significantly higher fibroblast count at 7 weeks compared to the Control group. The tendon bone repair distance, percentage perpendicular fibers, new bone formation at the tendon-bone interface, and collagen type III deposition was significantly greater for the Treatment group compared with the Control group at 12 weeks (P ≤ .05). A positive correlation was identified in the Treatment group between increased failure loads at 12 weeks and the following parameters: tendon-bone integration, new bone formation, and collagen type III. No statistically significant differences in biomechanical properties were identified between Treatment and Control Groups (P > .05). CONCLUSIONS: Use of a vented anchor attached to a bioresorbable interpositional scaffold composed of aligned PLGA microfibers improves the histologic properties of rotator cuff repairs in a sheep model. Improved histology was correlated with improved final construct strength at the 12-week time point.
BACKGROUND: The purpose of this study was to evaluate the biomechanical and histologic properties of rotator cuff repairs using a vented anchor attached to a bioresorbable interpositional scaffold composed of aligned PLGA (poly(l-lactide-co-glycoside)) microfibers in an animal model compared to standard anchors in an ovine model. METHODS: Fifty-six (n = 56) skeletally mature sheep were randomly assigned to a repair of an acute infraspinatus tendon detachment using a innovative anchor-PLGA scaffold device (Treatment) or a similar anchor without the scaffold (Control). Animals were humanely euthanized at 7 and 12 weeks post repair. Histologic and biomechanical properties of the repairs were evaluated and compared. RESULTS: The Treatment group had a significantly higher fibroblast count at 7 weeks compared to the Control group. The tendon bone repair distance, percentage perpendicular fibers, new bone formation at the tendon-bone interface, and collagen type III deposition was significantly greater for the Treatment group compared with the Control group at 12 weeks (P ≤ .05). A positive correlation was identified in the Treatment group between increased failure loads at 12 weeks and the following parameters: tendon-bone integration, new bone formation, and collagen type III. No statistically significant differences in biomechanical properties were identified between Treatment and Control Groups (P > .05). CONCLUSIONS: Use of a vented anchor attached to a bioresorbable interpositional scaffold composed of aligned PLGA microfibers improves the histologic properties of rotator cuff repairs in a sheep model. Improved histology was correlated with improved final construct strength at the 12-week time point.
Authors: Jeremiah Easley; James Johnson; Daniel Regan; Eileen Hackett; Anthony A Romeo; Ted Schlegel; Cecily Broomfield; Christian Puttlitz; Kirk McGilvray Journal: Vet Comp Orthop Traumatol Date: 2020-03-31 Impact factor: 1.358
Authors: James Johnson; Devin von Stade; Daniel Regan; Jeremiah Easley; Lyndah Chow; Steven Dow; Tony Romeo; Ted Schlegel; Kirk McGilvray Journal: Ann Transl Med Date: 2021-11
Authors: Erin McCready; Jeremiah T Easley; Makayla Risch; Kevin L Troyer; James W Johnson; Benjamin C Gadomski; Kirk C McGilvray; John D Kisiday; Brad B Nelson Journal: Cartilage Date: 2022 Jan-Mar Impact factor: 3.117
Authors: James Johnson; Devin von Stade; Daniel Regan; Jeremiah Easley; Lyndah Chow; Steven Dow; Tony Romeo; Ted Schlegel; Kirk McGilvray Journal: Ann Transl Med Date: 2021-05