Literature DB >> 31397156

Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation.

Aurora Rodríguez-Rodríguez1, Sergey Shuvaev1, Nicholas Rotile1, Chloe M Jones1, Clemens K Probst2, Diego Dos Santos Ferreira1, Katherine Graham-O Regan1, Eszter Boros1, Rachel S Knipe2, Jason W Griffith2, Andrew M Tager2, Alexei Bogdanov3, Peter Caravan1.   

Abstract

An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxidative conditions led to a 1.7-fold increase in r1 at 1.4 T that was attributed to an oligomerization of the probe upon oxidation. This probe, Gd-5-HT-DOTAGA, provided specific detection of lung inflammation by MRI in bleomycin-injured mice.

Entities:  

Keywords:  5-hydroxytryptamide; MRI; contrast agent; gadolinium; pulmonary fibrosis

Mesh：

Substances：

Year:  2019        PMID： 31397156      PMCID： PMC6924005          DOI： 10.1021/acssensors.9b01010

Source DB:  PubMed          Journal:  ACS Sens        ISSN： 2379-3694            Impact factor:   7.711


  31 in total

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2.  Oligomerization of paramagnetic substrates result in signal amplification and can be used for MR imaging of molecular targets.

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5.  Horseradish peroxidase oxidation of tyrosine-containing peptides and their subsequent polymerization: a kinetic study.

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6.  DTPA-bisamide-based MR sensor agents for peroxidase imaging.

Authors:  Manuel Querol; John W Chen; Ralph Weissleder; Alexei Bogdanov
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7.  Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase.

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Review 9.  Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

Authors:  Jessica Wahsner; Eric M Gale; Aurora Rodríguez-Rodríguez; Peter Caravan
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10.  High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material.

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  6 in total

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2.  A DNA-Based MRI Contrast Agent for Quantitative pH Measurement.

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3.  Improving the reactivity of hydrazine-bearing MRI probes for in vivo imaging of lung fibrogenesis.

Authors:  Eman A Akam; Eric Abston; Nicholas J Rotile; Hannah R Slattery; Iris Y Zhou; Michael Lanuti; Peter Caravan
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Review 4.  Activatable Nanoparticles: Recent Advances in Redox-Sensitive Magnetic Resonance Contrast Agent Candidates Capable of Detecting Inflammation.

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5.  Small-Molecule Bi-DOTA Complex for High-Performance CT and Spectral CT Bioimaging.

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6.  Multimodal Bone Metastasis-associated Epidermal Growth Factor Receptor Imaging in an Orthotopic Rat Model.

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  6 in total

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