Literature DB >> 15844889

DTPA-bisamide-based MR sensor agents for peroxidase imaging.

Manuel Querol1, John W Chen, Ralph Weissleder, Alexei Bogdanov.   

Abstract

[reaction: see text] The synthesis and some properties of two novel DTPA-bisamides are reported. These derivatives were designed as enzyme-activated contrast agents (CA) for magnetic resonance imaging. Both derivatives bear tyramido or 5-hydroxytryptamido groups that could be oligomerized in situ in the presence of peroxidase/H(2)O(2) pair resulting in a net increase in longitudinal (R1) relaxivity.

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Year:  2005        PMID： 15844889     DOI： 10.1021/ol050208v

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  34 in total

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