| Literature DB >> 31396127 |
Giorgia Pace1, Graziella Orrù2, Merylin Monaro1, Francesca Gnoato1, Roberta Vitaliani3, Kyle B Boone4, Angelo Gemignani2, Giuseppe Sartori1.
Abstract
Objective: Here we report an investigation on the accuracy of the b Test, a measure to identify malingering of cognitive symptoms, in detecting malingerers of mild cognitive impairment. Method: Three groups of participants, patients with Mild Neurocognitive Disorder (n = 21), healthy elders (controls, n = 21), and healthy elders instructed to simulate mild cognitive disorder (malingerers, n = 21) were administered two background neuropsychological tests (MMSE, FAB) as well as the b Test.Entities:
Keywords: Italian population; b Test; cognitive performance validity; malingering; mild cognitive impairment; mild dementia
Year: 2019 PMID: 31396127 PMCID: PMC6664275 DOI: 10.3389/fpsyg.2019.01650
Source DB: PubMed Journal: Front Psychol ISSN: 1664-1078
Demographic characteristics and performance on b Test for each group of participants and Kruskal-Wallis ANOVAs.
| Patients (Group A) | Healthy controls (Group B) | Malingerers (Group C) | Significance level ( | |
|---|---|---|---|---|
| Age (mean ± standard deviation) | 74.52 ± 6.49 | 73.14 ± 6.22 | 72.62 ± 5.25 | 0.478 |
| Education (mean ± standard deviation) | 6.29 ± 2.14 | 6.67 ± 2.26 | 8.14 ± 3.50 | 0.103 |
| MMSE (mean ± standard deviation) | 23.61 ± 1.90 | 28.10 ± 1.18 | 28.52 ± 1.25 | <0.0001 |
| FAB (mean ± standard deviation) | 11.71 ± 2.14 | 15.90 ± 1.60 | 16.57 ± 1.32 | <0.0001 |
| Omission errors (mean ± standard deviation) | 34.28 ± 17.47 | 17.95 ± 10.54 | 184.90 ± 76.88 | <0.0001 |
| Commission errors (mean ± standard deviation) | 22.85 ± 49.69 | 1.29 ± 2.76 | 412.14 ± 320.40 | <0.0001 |
|
| 13.81 ± 31.88 | 1.14 ± 2.71 | 81.71 ± 64.73 | <0.0001 |
| Response time | 1020.85 + −517,841 | 634.76 ± 236.23 | 981.47 ± 437.63 | 0.001 |
| E-score | 468.99 ± 840.65 | 82.69 ± 69.04 | 5246.29 ± 3792.5 | <0.0001 |
Mann-Whitney U comparisons among groups on b Test scores.
| Feature | U test | Significance level ( |
|---|---|---|
| Omission errors | 95.000 | 0.002 |
| Commission errors | 75.500 | 0.001 |
| d errors | 97.000 | 0.001 |
| Total response time | 76.500 | 0.001 |
| E-score | 56.000 | <0.0001 |
| Omission errors | 28.000 | <0.0001 |
| Commission errors | 58.500 | <0.0001 |
| d errors | 79.00 | <0.0001 |
| Total response time | 207.00 | 0.734 |
| E-score | 52.000 | <0.0001 |
| Omission errors | 18.500 | <0.0001 |
| Commission errors | 21.000 | <0.0001 |
| d errors | 28.500 | <0.0001 |
| Total response time | 106.000 | 0.004 |
| E-score | 11.000 | <0.0001 |
b Test score cut-offs with associated sensitivity and specificity in order to discriminate patients from simulators.
| Cut-off | Malingerers correctly classified | Patients correctly classified | Average accuracy | |
|---|---|---|---|---|
| Omission errors | >56 | 90.4% | 90% | 90.2 |
| Commission errors | >44 | 81% | 90% | 85.5 |
| E-score | >881 | 86% | 90% | 88 |
|
| >31 | 62% | 90% | 76 |
| Total response time (sec) | >1,498 | 14% | 90% | 52 |
Cut-offs reported here are computed without cross-validation and may suffer from overfitting, while average classification accuracy with E-score is 88%, the same figures resulted with leave-one-out cross-validation drops to 66%.
Accuracies as measured by % correct, area under the curve (AUC) and F1 obtained by five different ML classifiers in leave-one-out cross validation.
| Classifier | Accuracy in LOOCV (%) | AUC | F1 |
|---|---|---|---|
| Naïve Bayes | 90.47 | 0.89 | 0.90 |
| Logistic regression | 90.47 | 0.85 | 0.94 |
| Simple logistics | 92.9 | 0.91 | 0.93 |
| Support vector machine | 88.09 | 0.88 | 0.92 |
| Random forest | 90.47 | 0.89 | 0.90 |
Perfect classification of exemplars in the two categories has an AUC of 1 and a F1 of 1. AUC stands for area under the curve in ROC analysis and F1. Here, the input variables are those listed in Table 3. Some classifiers such as Simple Logistic Regression drop out the less useful predictors.
Comparison between patients and malingerers, correctly identified by each classifier.
| Classifier | Correct classification of patients | Correct classification of malingerers |
|---|---|---|
| Naïve Bayes | 19/21 | 19/21 |
| Logistic regression | 21/21 | 17/21 |
| Simple logistics | 21/21 | 18/21 |
| Support vector machine | 21/21 | 16/21 |
| Random forest | 20/21 | 18/21 |