| Literature DB >> 31391594 |
Wubin Bai1,2, Jiho Shin3, Ruxing Fu4, Irawati Kandela5,6, Di Lu1,2, Xiaoyue Ni1,2, Yoonseok Park1,2, Zhonghe Liu7, Tao Hang8, Di Wu2,9, Yonghao Liu7, Chad R Haney6,10, Iwona Stepien5,6, Quansan Yang2,11, Jie Zhao1,2, Khizar Rehan Nandoliya12, Hao Zhang1,2,13, Xing Sheng14, Lan Yin4, Keith MacRenaris6,10, Anlil Brikha6,10, Fraser Aird5,6, Maryam Pezhouh15, Jessica Hornick16, Weidong Zhou7, John A Rogers17,18,19,20,21,22,23,24.
Abstract
Capabilities in real-time monitoring of internal physiological processes could inform pharmacological drug-delivery schedules, surgical intervention procedures and the management of recovery and rehabilitation. Current methods rely on external imaging techniques or implantable sensors, without the ability to provide continuous information over clinically relevant timescales, and/or with requirements in surgical procedures with associated costs and risks. Here, we describe injectable classes of photonic devices, made entirely of materials that naturally resorb and undergo clearance from the body after a controlled operational lifetime, for the spectroscopic characterization of targeted tissues and biofluids. As an example application, we show that the devices can be used for the continuous monitoring of cerebral temperature, oxygenation and neural activity in freely moving mice. These types of devices should prove useful in fundamental studies of disease pathology, in neuroscience research, in surgical procedures and in monitoring of recovery from injury or illness.Entities:
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Year: 2019 PMID： 31391594 DOI： 10.1038/s41551-019-0435-y
Source DB: PubMed Journal: Nat Biomed Eng ISSN： 2157-846X Impact factor: 25.671