Literature DB >> 31390932

LINC01133 promotes the progression of cervical cancer by sponging miR-4784 to up-regulate AHDC1.

Yan Feng1, Luyun Qu2, Xiuli Wang2, Chunyan Liu2.   

Abstract

Cervical cancer, as the deadliest gynecological tumor with high risk of incidence, manifests aberrantly expressed lncRNAs in the malignant cellular processes. Long intergenic non-protein coding RNA 1133 (LINC01133) has been acknowledged to actively participate in aggressive tumor phenotypes. Our study focused on the identification of the function and corresponding mechanism of the novel molecule, LINC01133 in cervical cancer. LINC01133 expression profile was validated by digging The Cancer Genome Atlas (TCGA) database and qRT-PCR analysis. A considerably up-regulated expression of LINC01133 was unveiled. The results of CCK-8, trypan blue exclusion, EdU and transwell migration assays manifested the facilitating property of LINC01133 in cervical cancer. The epithelial-mesenchymal transition (EMT) was also exacerbated by LINCO1133. Apoptotic rate of cervical cancer cells was promoted after silencing LINCO1133. Mechanically, LINC01133 functioning as a ceRNA targeted miR-4784 to augment AHDC1 expression. Finally, LINCO1133/miR-4784 aggravated the malignant growth and aggressiveness and EMT of cervical cancer in an AHDC1-dependant way.

Entities:  

Keywords:  AHDC1; EMT; LINCO1133; cervical cancer; miR-4784

Mesh：

Substances：

Year:  2019        PMID： 31390932      PMCID： PMC6804813          DOI： 10.1080/15384047.2019.1647058

Source DB:  PubMed          Journal:  Cancer Biol Ther        ISSN： 1538-4047            Impact factor:   4.742


  36 in total

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Review 4.  LncRNAs: key players and novel insights into cervical cancer.

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Journal:  Tumour Biol       Date:  2015-12-29

5.  LINC01133 aggravates the progression of hepatocellular carcinoma by activating the PI3K/AKT pathway.

Authors:  Yong-Fa Zheng; Xiao-Yu Zhang; Yan-Zhi Bu
Journal:  J Cell Biochem       Date:  2018-12-11       Impact factor: 4.429

6.  Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.

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Review 7.  Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA.

Authors:  Iain M Dykes; Costanza Emanueli
Journal:  Genomics Proteomics Bioinformatics       Date:  2017-05-19       Impact factor: 7.691

8.  LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway.

Authors:  Xian-Zi Yang; Tian-Tian Cheng; Qing-Jun He; Zi-Ying Lei; Jun Chi; Zhen Tang; Quan-Xing Liao; Hong Zhang; Li-Si Zeng; Shu-Zhong Cui
Journal:  Mol Cancer       Date:  2018-08-22       Impact factor: 27.401

9.  Long Noncoding RNA LINC01133 Functions as an miR-422a Sponge to Aggravate the Tumorigenesis of Human Osteosarcoma.

Authors:  Hai-Feng Zeng; Hai-Yan Qiu; Fa-Bo Feng
Journal:  Oncol Res       Date:  2017-03-28       Impact factor: 5.574

10.  LncRNA XLOC_006390 facilitates cervical cancer tumorigenesis and metastasis as a ceRNA against miR-331-3p and miR-338-3p.

Authors:  Xiaotian Luan; Yankui Wang
Journal:  J Gynecol Oncol       Date:  2018-11       Impact factor: 4.401
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  9 in total

Review 1.  New Sights Into Long Non-Coding RNA LINC01133 in Cancer.

Authors:  Shengnan Jiang; Qian Zhang; Jiaqi Li; Khadija Raziq; Xinyu Kang; Shiyin Liang; Chaoyue Sun; Xiao Liang; Di Zhao; Songbin Fu; Mengdi Cai
Journal:  Front Oncol       Date:  2022-06-07       Impact factor: 5.738

2.  Serum lncRNAs (CCAT2, LINC01133, LINC00511) with Squamous Cell Carcinoma Antigen Panel as Novel Non-Invasive Biomarkers for Detection of Cervical Squamous Carcinoma.

Authors:  Wen-Jie Wang; Di Wang; Mei Zhao; Xiao-Jie Sun; Yan Li; Hong Lin; Yi-Qun Che; Chang-Zhi Huang
Journal:  Cancer Manag Res       Date:  2020-10-01       Impact factor: 3.989

3.  ELK1 activated-long noncoding RNA LBX2-AS1 aggravates the progression of ovarian cancer through targeting miR-4784/KDM5C axis.

Authors:  Hangzhi Gu; Rongrong Lin; Feiyun Zheng; Qian Zhang
Journal:  J Mol Histol       Date:  2020-10-24       Impact factor: 2.611

4.  Tumor-derived exosomal long noncoding RNA LINC01133, regulated by Periostin, contributes to pancreatic ductal adenocarcinoma epithelial-mesenchymal transition through the Wnt/β-catenin pathway by silencing AXIN2.

Authors:  Yang Liu; Tianchi Tang; Xiaosheng Yang; Peng Qin; Pusen Wang; Huiping Zhang; Min Bai; Rong Wu; Fan Li
Journal:  Oncogene       Date:  2021-04-06       Impact factor: 9.867

Review 5.  A review on the role of LINC01133 in cancers.

Authors:  Soudeh Ghafouri-Fard; Tayyebeh Khoshbakht; Bashdar Mahmud Hussen; Mohammad Taheri; Majid Mokhtari
Journal:  Cancer Cell Int       Date:  2022-08-30       Impact factor: 6.429

6.  AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewing's sarcoma cells.

Authors:  Takao Kitagawa; Daiki Kobayashi; Byron Baron; Hajime Okita; Tatsuo Miyamoto; Rie Takai; Durga Paudel; Tohru Ohta; Yoichi Asaoka; Masayuki Tokunaga; Koji Nakagawa; Makoto Furutani-Seiki; Norie Araki; Yasuhiro Kuramitsu; Masanobu Kobayashi
Journal:  PLoS One       Date:  2022-10-04       Impact factor: 3.752

7.  Long intergenic noncoding RNA01134 accelerates hepatocellular carcinoma progression by sponging microRNA-4784 and downregulating structure specific recognition protein 1.

Authors:  Shiyang Zheng; Yan Guo; Lizhen Dai; Ziming Liang; Qing Yang; Shuhong Yi
Journal:  Bioengineered       Date:  2020-12       Impact factor: 3.269

8.  Whole genome sequencing identifies rare germline variants enriched in cancer related genes in first degree relatives of familial pancreatic cancer patients.

Authors:  Ming Tan; Klaus Brusgaard; Anne-Marie Gerdes; Michael Bau Mortensen; Sönke Detlefsen; Ove B Schaffalitzky de Muckadell; Maiken Thyregod Joergensen
Journal:  Clin Genet       Date:  2021-08-03       Impact factor: 4.296

9.  LINC01133 promotes hepatocellular carcinoma progression by sponging miR-199a-5p and activating annexin A2.

Authors:  Dan Yin; Zhi-Qiang Hu; Chu-Bin Luo; Xiao-Yi Wang; Hao-Yang Xin; Rong-Qi Sun; Peng-Cheng Wang; Jia Li; Jia Fan; Zheng-Jun Zhou; Jian Zhou; Shao-Lai Zhou
Journal:  Clin Transl Med       Date:  2021-05
  9 in total

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